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| 1 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 2 | 一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统显示文摘文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)成像技术是最常用的诊断技术之一。 | Daniel S.Kermany Michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown Ge Yang Xiaokang Wu Fangbing Yan Justin Dong Made K.Prasadha Jacqueline Pei Magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason Dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu Cindy Wen Edward D. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaodong Sun Jie Xu Ali Tafreshi M. Anthony Lewis Huimin Xia 张康 | 2019 | 科学新闻2019，0，2： | 1 |
| 3 | Future Science Prize goes to non-invasive prenatal testing显示文摘The Future Forum,a non-profit organization established last year in Beijing,announced that pathologist Dennis Ming Yuk Lo from the Chinese University of Hong Kong won the life sciences Future Science Prize for the discovery of fetal cell-free DNA(cfDNA)in maternal plasma in 1997(Lo et al.,1997).By detecting male fetus-derived Y sequences in maternal plasma,Lo et al.successfully proved the presence of fetal cfDNA in maternal plasma and serum(Lo et al.,1997).This discovery has opened up a tremendous breadth of | Kang Li Yaou Duan Magdalene Yin Lin Ting Zhiying Ou Li Liu Kang Zhang Xin Fu | 2017 | Science China(Life Sciences)2017，60，4： | 0 |
| 4 | CRISPR/Cas9 mediated somatic gene therapy for insertional mutations:the vibrator mouse model显示文摘Somatic gene therapy remains technically challenging,especially in the central nervous system(CNS).Efficiency of gene delivery,efficacy in recipient cells,and proportion of cells required for overall benefit are the key points needed to be considered in any therapeutic approach.Recent efforts have demonstrated the efficacy of RNA-guided nucleases such as CRISPR/Cas9 in correcting point mutations or removing dominant mutations.Here we used viral delivered Cas9 plasmid and two guide RNAs to remove a recessive insertional mutation,vibrator(vb),in the mouse brain.The vb mice expressed∼20%of normal levels of phosphatidylinositol transfer protein,α(PITPα)RNA and protein due to an endogenous retrovirus inserted in intron 4,resulting in early-onset tremor,degeneration of brainstem and spinal cord neurons,and juvenile death.The in situ CRISPR/Cas9 viral treatment effectively delayed neurodegeneration,attenuated tremor,and bypassed juvenile death.Our studies demonstrate the potential of CRISPR/Cas9-mediated gene therapy for insertional mutations in the postnatal brain. | Xin Fu Jie Zhu Yaou Duan Paul Lu Kang Zhang | 2021 | Precision Clinical Medicine2021，4，3： | 0 |
| 5 | Author Correction:Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘In the in itial published versi on of this article,we in advertently stated that Mall procedures were con ducted with the approval and under the supervision of the Institutional Animal Care and Use Committee(IACUC)at the University of California,San Diego'.Given that all animal work that was conducted for this project was performed at the City University of Hong Kong and Guangzhou Women and Childre n's Medical Center,we would like to in stead,acknowledge these programs for their oversight of the animal studies.This correction does not affect the description of the results or the conclusions of this work. | Jie Zhu Chang Ming Xin Fu Yaou Duan Due Anh Hoang Jeffrey Rutgard Runze Zhang Wenqiu Wang Rui Hou Daniel Zhang Edward Zhang Charlotte Zhang Eye Gene Therapy Consortium Xiaoke Hao Wenjun Xiong Kang Zhang | 2019 | Cell Research2019，29，4： | 0 |
| 6 | Clinical applications of retinal gene therapies显示文摘Retinal degenerative diseases are a major cause of blindness.Retinal gene therapy is a trail-blazer in the human gene therapy field,leading to the frst FDA approved gene therapy product for a human genetic disease.The application of Clustered Regularly Interspaced Short Palindromic Repeat/Cas9(CRISPR/Cas9)-mediated gene editing technology is transforming the delivery of gene therapy.We review the history,present,and future pro-spects of retinal gene therapy. | Xin Fu Viet Anh Nguyen Huu Yaou Duan Daniel S.Kermany Carolina C.S.Valentim Runze Zhang Jie Zhu Charlotte L.Zhang Xiaodong Sun Kang Zhang | 2018 | Precision Clinical Medicine2018，1，1： | 0 |
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