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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Polyamines reduces lipid peroxidation induced by different pro-oxidant agents显示文摘 | Nádia Aléssio Velloso Bellé Gerusa Duarte Dalmolin Graciela Fonini Maribel Antonello Rubin Jo?o Batista Teixeira Rocha | 2004 | Brain Research2004，，2： | 3 |
| 3 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 4 | Full survival of paraquat-exposed rats after treatment with sodium salicylate显示文摘 | R.J. Dinis-Oliveira C. Sousa F. Remi?o J.A. Duarte A. Sánchez Navarro M.L. Bastos F. Carvalho | 2007 | Free Radical Biology and Medicine2007，，7： | 2 |
| 5 | Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment显示文摘 | R. J. Dinis-Oliveira J. A. Duarte A. Sánchez-Navarro F. Remi?o M. L. Bastos F. Carvalho | 2008 | CRC Critical Reviews in Toxicology2008，，1： | 2 |
| 6 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
| 7 | Oil sludge treatment by photocatalysis applying black and white light显示文摘 | ROCHA O R S DANTAS R F DUARTE M M M B | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 8 | Element-resolved corrosion analysis of stainless-type glass-forming steels显示文摘 | Duarte M J Klemm J Klemm S O | 2013 | Science2013，341，6144： | 1 |
| 9 | Determination of pH and calcium ion release provided by pure and calcium hydroxide-containing AHPlus显示文摘 | Duarte MA de O Demarchi AC de Moraes IG | | 0，，01： | 1 |
| 10 | Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats显示文摘 | Duarte J Jimenez R O' Valle F | 2002 | J Hypertens2002，20，9： | 1 |
| 11 | Myocardial infarction in the 31 st week of pregnancy-- case report显示文摘 | Duarte FP O'Neill P Centeno MJ | 2011 | Rev Bras Anestesiol2011，61，： | 1 |
| 12 | A new cloud-based hp finite element method显示文摘 | ODEN J T DUARTE C A ZIENKIEWICZ O C | 1998 | International Journal for Numerical Methods in Engineering1998，，50： | 1 |
| 13 | A new cloudbased hp finite element method显示文摘 | Oden J T Duarte C A Zienkiewicz O C | 1998 | Computer Methods in Applied Mechanics and Engineering1998，153，： | 1 |
| 14 | Developing scalable protocols for three-metric QoS routing显示文摘 | Costa L Fdida S Duarte O | 2002 | Computer Networks2002，39，6： | 1 |
| 15 | Paraquat poisonings : mechanisms of lung toxicity, clinical features, and treatment 显示文摘 | Dinis-Oliveira R J Duarte JA Sanchez-Navan'o A | 2008 | Crit Rev Toxicol2008，38，1： | 1 |
| 16 | Envelope-related energy demand: A design indicator of energy performance for residential buildings in early design stages显示文摘 | Vasco Granadeiro Jo?o R. Correia Vítor M.S. Leal José P. Duarte | 2013 | Energy & Buildings2013，，： | 1 |
| 17 | A new cloud-based Hp finite element method显示文摘 | Oden J T Duarte C A Zienkiewicz O C | 1998 | Int J Numer Methods Engrg1998，50，： | 1 |
| 18 | Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model 显示文摘 | DUARTE N C HERRGARD M J PALSSON B O | 2004 | Genome Research2004，14，7： | 1 |
| 19 | Evaluation of the components of a commercial probiotic ingnotobiotic mice experimentally challenged with Salmonella enterica subspentericaser显示文摘 | Maia O B Duarte R Silva A M | 2001 | Vet Cryobiol Microbiol2001，79，2： | 1 |
| 20 | Accuracy of the first endoscopic procedure in the differential diagnosis of gastric lesions显示文摘 | Llanos O GuzmanS Duarte I | 1982 | Ann Surg1982，195，2： | 1 |
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