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| 1 | Identifying digital and fractional transfer functions from a frequency response显示文摘 | DUARTE Valerio JOSE Sa da Costa | 2011 | International Journal of Control2011，84，3： | 1 |
| 2 | Tuning of fractional laiD controllers with Ziegler-Nichols-type rules显示文摘 | DUARTE VALRRIO JOSE SA DA COSTA | 2006 | Signal Pro- cessing2006，86，10： | 1 |
| 3 | Global reconstruction of the human metabolic network based on genomic and bibliomic data显示文摘 | Duarte NC Becker SA Jamshidi N | | 0，，： | 1 |
| 4 | Leydig cell tumor: Report of 8 cases and review of the literature 显示文摘 | Cruceyra Betriu G Tejido Sa nchez A Duarte Ojeda JM Garcv a De La Torre JP De La Morena Gallego JM Marry nez Silva V | 2002 | Aetas Urol Esp2002，26，： | 1 |
| 5 | Linear model identification of the archimedes wave swing 显示文摘 | PEDRO Beiro DUARTE Valerio Jose Sa da Costa | 2007 | Powereng2007，，： | 1 |
| 6 | Ventrieular remodeling af- ter myocardial infarction : concepts and clinical implications 显示文摘 | Zornoff LA Paiva SA Duarte DR | 2009 | Arq Bras Capfliol2009，92，2： | 1 |
| 7 | Water use in the Spanish economy: an imput/output approach 显示文摘 | Rosa Duarte Julio Sa' nchez-Cho' liz | 2002 | Ecological Econmics2002，43，： | 1 |
| 8 | Ventricular remodeling after myocardial infarction: concepts and clinical implications 显示文摘 | Zornoff LA Paiva SA Duarte DR | 2009 | Arq Bras Cardiol2009，92，2： | 1 |
| 9 | Global reconstruction of the human metabolic network based on genomic and bibliomic data显示文摘 | Duarte NC Becker SA Jamshidi N | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，： | 1 |
| 10 | Filling of simulated lateral canals with gutta-percha or Resilon when using thermomechanical compaction 显示文摘 | Anna-Jtnior SA Tanomaru-Filho M Duarte MA | 2014 | J Conserv Dent2014，17，3： | 1 |
| 11 | PROFIT-maximizing stocking ratesfor channel catfish in cages显示文摘 | Duarte SA Nelson R Masser M P | 1994 | J World Aquac Soc1994，25，3： | 1 |
| 12 | Global reconstruction of the human metabolic network based on genomic and bibliomicdata显示文摘 | Duarte NC Becker SA Jamshidi N | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，： | 1 |
| 13 | A Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment显示文摘 | DINIS--OLIVEIRA R J DUARTE J A SA NCHEZ --NAVARRO | 2008 | Crit Rev Toxicol2008，38，： | 1 |
| 14 | Water use in the Spanish economy: an input_/output approach 显示文摘 | Rosa Duarte Julio Sa' nchez-Cho' liz | 2002 | Ecological Economics2002，43，： | 1 |
| 15 | Paraquat poisonings:mechanisms of lung toxicity,clinical features,and treatment显示文摘 | Dinis-Oliveira RJ Duarte JA Sa'nchez-Navarro A | 2008 | Crit Rev Toxicol2008，38，： | 1 |
| 16 | Water use in the Spanish economy: An input/output approach 显示文摘 | Rosa Duarte Julio Sa'nchez Cho'liz | 2002 | Ecological Economics2002，43，： | 1 |
| 17 | Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts显示文摘BACKGROUND Guanine nucleotide-binding protein,alpha stimulating(GNAS)mutations are characteristic of intraductal papillary mucinous neoplasms(IPMNs).Pancreatic ductal adenocarcinomas(PDACs)harboring GNAS mutations originate in IPMNs.GNAS is a complex imprinted locus that produces five transcripts regulated by differential methylated regions,NESP55,GNASAS,GNASXL,GNAS1A,and GNAS.AIM To evaluate if methylation changes in the differential methylated regions of GNAS locus contributed to malignant progression of pancreatic cysts.METHODS GNAS locus methylation was analyzed in archival pancreatic cyst fluid(PCF)obtained by endoscopic ultrasound with fine-needle aspiration by methylation specific–multiplex ligation dependent probe amplification.Results were normalized and analyzed using Coffalyser.Net software.RESULTS Fifty-two PCF samples obtained by endoscopic ultrasound with fine-needle aspiration and previously characterized for KRAS and GNAS mutations were studied.The final diagnoses were surgical(11)and clinicopathological(41),including 30 benign cysts,14 pre-malignant cyst,and eight malignant cysts.Methylation changes at NESP55,GNASAS,GNAS1A,and especially GNASXL were more frequent in malignant cysts,and NESP55 and GNASAS were useful for diagnosis.A combined variable defined as“GNAS locus methylation changes”was significantly associated with malignancy(6/8 malignant cysts and only 2/20 benign cysts)and improved classification.Hypermethylation in both maternally(NESP55)and paternally(GNASXL)derived promoters was found in 3/3 PDACs.CONCLUSION This is the first study to identify methylation changes in the GNAS locus,improving the diagnosis of malignant pancreatic cysts and suggesting a role in progression to PDAC. | Sandra Faias Marlene Duarte Luísa Pereira Paula Chaves Marília Cravo Antonio Dias Pereira Cristina Albuquerque | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 0 |
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