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| 1 | 中国首次岸基GNSS-R海洋遥感实验显示文摘GNSS-Reflection技术是一种崭新的海洋遥感技术.它利用导航卫星的海面反射信号可获取海浪、潮汐及海面风场等重要信息,是海洋遥感的前沿领域.报道了中国岸基GNSS-R海洋遥感实验——CORE实验,研究了利用GPS卫星直达波与反射波信号反演海洋参数的方法,给出了有效波高的最新反演结果,并利用同步观测进行了对比验证. | 王鑫 孙强 张训械 吕达仁 邵连军 胡雄 Ruffini Giulio Dunne Stephen Francois Soulat | 2008 | 科学通报2008，53，5： | 25 |
| 2 | First China ocean reflection experiment using coastal GNSS-R显示文摘It is a new way for oceanographic remote sensing using the GNSS-Reflection technique. Sea waves, tides and sea surface wind can be obtained by analyzing the direct and reflected GPS signals from sea surface. It has become an advanced field concerned by many researchers. In this paper the first China Ocean Reflection Experiment (CORE) with the coastal GNSS-R in the southeast is reported and the method to retrieve oceanographic parameters with the direct and reflected GPS signals is studied. The primary retrievals of Significant Wave Height (SWH) are presented and also compared with the meas-urements from Ultrasonic Wave Gauge (UWG) in situ. | WANG Xin SUN Qiang ZHANG XunXie LU DaRen SHAO LianJun HU Xiong RUFFINI Giulio DUNNE Stephen FRANCOIS Soulat | 2008 | Chinese Science Bulletin2008，53，7： | 15 |
| 3 | Long-Term Preservation of Vision in Progressive Outer Retinal Necrosis Treated with Combination Antiviral Drugs and Highly Active Antiretroviral Therapy显示文摘 | Stephen J. Kim Robert Equi Marie-Lyne Belair Howard F. Fine James P. Dunn | 2007 | Ocular Immunology and Inflammation2007，，6： | 1 |
| 4 | Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease显示文摘 | Stephen SL Freestone K Dunn S | | 0，，： | 1 |
| 5 | Nursing experience and the care of dying patients显示文摘 | Dunn K S Otten C Stephens E | | 0，，5： | 1 |
| 6 | Ocular injury requiring hospitalisation in the South East of Ireland: 2001–2007显示文摘 | Ayman Saeed Irfan Khan Orla Dunne Jim Stack Stephen Beatty | 2009 | Injury2009，，1： | 1 |
| 7 | High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial显示文摘 | John F Tisdale Daniel E Dunn Nancy Geller Michelle Plante Olga Nunez Cynthia E Dunbar A John Barrett Thomas J Walsh Stephen J Rosenfeld Neal S Young | 2000 | 2000 (9241)2000，，9241： | 1 |
| 8 | Adiponectin regulates albuminuria and podocyte function in mice显示文摘 | Sharma Kumar RamachandraRao Satish Qiu Gang Usui Hitomi Kataoka Zhu Yanqing Dunn Stephen R Ouedraogo Raogo Hough Kelly McCue Peter Chan Lawrence Falkner Bonita Goldstein Barry J | 2008 | Journal of Clinical Investigation2008，，5： | 1 |
| 9 | Bioterrorism: Evaluating the Preparedness of Pediatricians in Michigan显示文摘 | Curt Stankovic Prashant Mahajan Hong Ye Robert B. Dunne Stephen R. Knazik | 2009 | Pediatric Emergency Care2009，，2： | 1 |
| 10 | High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial显示文摘 | John F Tisdale Daniel E Dunn Nancy Geller Michelle Plante Olga Nunez Cynthia E Dunbar A John Barrett Thomas J Walsh Stephen J Rosenfeld Neal S Young | 2000 | The Lancet2000，，9241： | 1 |
| 11 | Enhanced recovery in the resection of colorectal liver metastases显示文摘 | Declan F. J. Dunne Vincent S. Yip Robert P. Jones Ewan A. McChesney Daniel T. Lythgoe Eftychia E. Psarelli Louise Jones Carmen Lacasia‐Purroy Hassan Z. Malik Graeme J. Poston Stephen W. Fenwick | 2014 | J. Surg. Oncol2014，，2： | 1 |
| 12 | Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular dis-ease显示文摘 | Stephen SL Freestone K Dunn S | | 0，，： | 1 |
| 13 | Feasibility of Negative Pressure Wound Therapy During Intercontinental Aeromedical Evacuation of Combat Casualties显示文摘 | Raymond Fang Warren C. Dorlac Stephen F. Flaherty Caroline Tuman Steven M. Cain Tracy L. C. Popey Douglas R. Villard Jayson D. Aydelotte James R. Dunne Adam M. Anderson Elisha T. Powell | 2010 | The Journal of Trauma: Injury, Infection, and Critical Care . 2010 (1 Su)2010，，1： | 1 |
| 14 | Adiponectin regulates albuminuria and podocyte function in mice显示文摘 | Sharma Kumar RamachandraRao Satish Qiu Gang Usui Hitomi Kataoka Zhu Yanqing Dunn Stephen R Ouedraogo Raogo Hough Kelly McCue Peter Chan Lawrence Falkner Bonita Goldstein Barry J | 2008 | Journal of Clinical Investigation2008，，5： | 1 |
| 15 | Improvements in thermionie cooling through engi- neering of the heterostructure interface using Monte Carlo simulations 显示文摘 | STEPHEN A DUNN G M OXLEYC H | 2013 | Journal of Applied Phys- ics2013，114，04： | 1 |
| 16 | Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma显示文摘BACKGROUND In the contemporary era of cancer immunotherapy,an abundance of clinical and translational studies have reported radiotherapy(RT)and immunotherapies as a viable option for immunomodulation of many cancer subtypes,with many related clinical trials ongoing.In locally advanced disease,chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma(OAC),however,the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative setting.AIM To immunophenotype OAC patients’immune checkpoint(IC)expression with and without radiation and evaluate the effects of checkpoint blockade on cell viability.METHODS In the contemporary era of cancer immunotherapy,an abundance of studies have demonstrated that combination RT and IC inhibitors(ICIs)are effective in the immunomodulation of many cancer subtypes,with many related clinical trials ongoing.Although surgical excision and elimination of tumour cells by chemotherapy or chemoradiotherapy remains the gold standard approach in OAC,the propagation of anti-tumour immune responses is rapidly garnering increased support in the curative setting.The aim of this body of work was to immunophenotype OAC patients’IC expression with and without radiation and to establish the impact of checkpoint blockade on cell viability.This study was a hybrid combination of in vitro and ex vivo models.Quantification of serum immune proteins was performed by enzyme-linked immunosorbent assay.Flow cytometry staining was performed to evaluate IC expression for in vitro OAC cell lines and ex vivo OAC biopsies.Cell viability in the presence of radiation with and without IC blockade was assessed by a cell counting kit-8 assay.RESULTS We identified that conventional dosing and hypofractionated approaches resulted in increased IC expression(PD-1,PD-L1,TIM3,TIGIT)in vitro and ex vivo in OAC.There were two distinct subcohorts with one demonstrating significant upregulation of ICs and the contrary in the other cohort.Increasing IC expression post RT was associated with a more aggressive tumour phenotype and adverse features of tumour biology.The use of anti-PD-1 and anti-PD-L1 immunotherapies in combination with radiation resulted in a significant and synergistic reduction in viability of both radiosensitive and radioresistant OAC cells in vitro.Interleukin-21(IL-21)and IL-31 significantly increased,with a concomitant reduction in IL-23 as a consequence of 4 Gray radiation.Similarly,radiation induced an anti-angiogenic tumour milieu with reduced expression of vascular endothelial growth factor-A,basic fibroblast growth factor,Flt-1 and placental growth factor.CONCLUSION The findings of the current study demonstrate synergistic potential for the use of ICIs and ionising radiation to potentiate established anti-tumour responses in the neoadjuvant setting and is of particular interest in those with advanced disease,adverse features of tumour biology and poor treatment responses to conventional therapies. | Noel E Donlon Maria Davern Fiona O'Connell Andrew Sheppard Aisling Heeran Anshul Bhardwaj Christine Butler Ravi Narayanasamy Claire Donohoe James J Phelan Niamh Lynam-Lennon Margaret R Dunne Stephen Maher Jacintha O'Sullivan John V Reynolds Joanne Lysaght | 2022 | World Journal of Gastroenterology2022，28，21： | 1 |
| 17 | Magnetic resonance cholangiopancreatography versus endoscopic retrograde cholangiopancreatography in the diagnosis of choledocholithiasis显示文摘 | Nyree Griffin Martin L. Wastle William K. Dunn Stephen D. Ryder Ian J. Beckingham | 2003 | European Journal of Gastroenterology & Hepatology2003，，7： | 1 |
| 18 | Nursing experience and the care of dying patients显示文摘 | Dunn KS Otten C Stephens E | 2005 | Oncol Nurs Forum2005，32，1： | 1 |
| 19 | Failure of immunosuppressive drug levels to predict T-cell reactivity in pediatric transplant patients显示文摘 | Valerie B. Sampson Stephen P. Dunn Beth Rymeski James Malatack Nancy H. Rong Louise Flynn Leslie J. Krueger | 2008 | Journal of Pediatric Surgery2008，，6： | 1 |
| 20 | Improvements in thermionic cooling through engineering of the het- erostructure interface using Monte Carlo simulations 显示文摘 | Stephen A Dunn G M Oxley C H | 2013 | Journal of Applied Physics2013，114，04： | 1 |
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