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| 1 | Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage显示文摘The Chinese compound Kaixin Jieyu Fang can be used to treat vascular depression;however,the underlying mechanism remains unclear.This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries.Rats received daily intragastric administration of a suspension of Kaixin Jieyu Fang powder.After 3,7and 21 days of treatment,the degree of white matter damage in the cerebral ischemia rat model was alleviated,Bcl-2 protein and mRNA expression in brain tissue increased,and Bax protein and mRNA expression decreased.These results indicate that Kaixin Jieyu Fang can alleviate cerebral white matter damage,and the underlying mechanism is associated with regulation of Bcl-2/Bax protein and mRNA expression,which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression. | Ying Zhang Shijing Huang Yanyun Wang Junhua Pan Jun Zheng Xianhui Zhang Yuxia Chen Duojiao Li | 2014 | Neural Regeneration Research2014，9，1： | 4 |
| 2 | A prophenoloxidase from the Chinese mitten crab Eriocheir sinensis : Gene cloning, expression and activity analysis显示文摘 | Yunchao Gai Jianmin Zhao Linsheng Song Chenghua Li Peilin Zheng Limei Qiu Duojiao Ni | 2007 | Fish and Shellfish Immunology2007，，2： | 1 |
| 3 | cDNA cloning and mRNA expression of heat shock protein 90 gene in the haemocytes of Zhikong scallop, Chlamys farreri 显示文摘 | Gao Qiang Song Linsheng Duojiao Ni | 2007 | Comparative Biochemistry and Physiology Part B2007，147，4： | 1 |
| 4 | The cDNA cloning and mRNA expression of heat shock protein 70 gene in the haemocytes of bay scallop (Argopecten irradians, Lamarck 1819) responding to bacteria challenge and naphthalin stress 显示文摘 | SONG Linsheng WU Longtao NI Duojiao | 2006 | Fish and Shellfish Immunology2006，21，4： | 1 |
| 5 | A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy显示文摘 | Zhen Zhao Soohwan Oh Dapeng Li Duojiao Ni Sara Dolatshahi Pirooz Joo-Hyung Lee Shunhua Yang June-Yong Lee Irene Ghozalli Vincenzo Costanzo Jeremy M. Stark Chengyu Liang | 2012 | Developmental Cell2012，，5： | 1 |
| 6 | A prophenoloxidase from the Chinese mitten crab Eriocheir sinensis : Gene cloning, expression and activity analysis显示文摘 | Yunchao Gai Jianmin Zhao Linsheng Song Chenghua Li Peilin Zheng Limei Qiu Duojiao Ni | 2007 | Fish and Shellfish Immunology2007，，2： | 1 |
| 7 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 8 | A multi-omic landscape of steatosis-to-NASH progression显示文摘Nonalcoholic steatohepatitis(NASH)has emerged as a major cause of liver failure and hepatocellular carcinoma.Investigation into the molecular mechanisms that underlie steatosis-to-NASH progression is key to understanding the development of NASH pathophysiology.Here,we present comprehensive multi-omic profiles of preclinical animal models to identify genes,non-coding RNAs,proteins,and plasma metabolites involved in this progression.In particular,by transcriptomics analysis,we identified Growth Differentiation Factor 3(GDF3)as a candidate noninvasive biomarker in NASH.Plasma GDF3 levels are associated with hepatic pathological features in patients with NASH,and differences in these levels provide a high diagnostic accuracy of NASH diagnosis(AUROC=0.90;95%confidence interval:0.85−0.95)with a good sensitivity(90.7%)and specificity(86.4%).In addition,by developing integrated proteomic-metabolomic datasets and performing a subsequent pharmacological intervention in a mouse model of NASH,we show that ferroptosis may be a potential target to treat NASH.Moreover,by using competing endogenous RNAs network analysis,we found that several miRNAs,including miR-582-5p and miR-292a-3p,and lncRNAs,including XLOC-085738 and XLOC-041531,are associated with steatosis-to-NASH progression.Collectively,our data provide a valuable resource into the molecular characterization of NASH progression,leading to the novel insight that GDF3 may be a potential noninvasive diagnostic biomarker for NASH while further showing that ferroptosis is a therapeutic target for the disease. | Liping Xiang Xiaoyan Li Yunchen Luo Bing Zhou Yuejun Liu Yao Li Duojiao Wu Lijing Jia Pei-Wu Zhu Ming-Hua Zheng Hua Wang Yan Lu | 2022 | Life Metabolism2022，1，3： | 0 |
| 9 | Empirical analysis of mass flow and operation performance of a full-scale biogas plant for human feces treatment显示文摘With the rapid development of urbanization in China,the existing municipal network cannot cover all areas and solve all human waste treatment problems.Biogas plants,as an important nationally developmental strategy for cleaner energy production and environmental protection,have been widely used in many industrial and agricultural fields.This research analyzed the mass flow and operation performance in a biogas plant treating human feces at a practical rather than laboratory scale.The biogas plant operated on mesophilic semi-continuous mode at the organic loading rates(OLRs)of 0.56 kg volatile solid(VS)/(m³·d)and average total solid(TS)contents of 3.50%.Results showed that the average biogas production and methane yield were(145±10)m³/d and(471±17)m³CH4/(t VS),respectively.Annual total feeding amount was 2555.0 t.Among these,there were 58.04 t biogas and 2496.97 t digestate,including 43.07 t solid residues and 2453.90 t liquid digestate.For the full-scale biogas plant,anaerobic bacteria could acclimatize to high total ammonia nitrogen(TAN)concentration(3659 mg/L)and tolerate high free ammonia nitrogen(FAN)concentration of 561 mg/L.It also had strong autoregulation for adapting the large range(2.02-15.18 g/L)and high concentration(15.18 g/L)of influent volatile fatty acid(VFA).In order to achieve its sustainable development and high efficient operation,it is very important to improve the feeding concentration,using digestate to dilute raw material and adding some high C/N raw material in human feces.In conclusion,the biogas plant was an excellent alternative technology for treating human feces. | Zhang Duojiao Duan Na Lin Cong Zhang Yilin Xu Qiuzi Liu Zhidan | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 0 |
| 10 | New Standardized Cultivation Techniques for Tea Seed Production显示文摘The tea from tea plants,a kind of traditional leaf plant,is deeply loved by people,but the production of tea fruit and its important functional value have been seriously underestimated for a long time.To this end,the oil plant function and comprehensive utilization value of tea oil from tea fruit were introduced,and a set of new standardized cultivation technique of tea plants that could fully exert the potential of tea seed yield was put forward.The technique could increase the tea seed yield per mu from less than 50kg in traditional tea gardens to more than 200 kg,which broke through the production mode of single leaf picking in traditional tea gardens,gave play to the natural reproductive growth advantages of tea plants,achieved'leaf-seed dual harvest',and promoted the improvement of tea industry quality and efficiency,thereby creating a new path to achieve the'leaf-fruit dual use'of tea plants. | Ming an YUAN Zegang ZHU Duojiao LI Xinrong HU Li JIANG Le CHEN Jintao KANG Zhaisheng ZHENG | 2022 | Agricultural Biotechnology2022，11，6： | 0 |
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