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| 1 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Blastic plasmacytoid dendritic cell neoplasms: clinico cal correlations in a series of 91 patients显示文摘 | Julia F Dalle S Duru G | 2014 | Am J Surg Pathol2014，38，5： | 1 |
| 3 | Comparison of different therapeutic strategies in hypertension: a low-dose combination of perindopril/indapamide versus a sequential monotherapy or a stepped-care approach显示文摘 | Jean-Jacques Mourad Bernard Waeber Fa?ez Zannad Maurice Laville Gérard Duru Michel Andréjak | 2004 | Journal of Hypertension2004，，12： | 1 |
| 4 | 显示文摘 | Yavuz H Duru E Omer G | 2003 | Colloids Surf A: Physicochem Eng Aspects2003，223，： | 1 |
| 5 | The relationship between serum YKL-40 levels and severity of asthma显示文摘 | Duru S Yuce G Ulasli SS | 2013 | Iranian J Allergy Asthma Immunol2013，12，3： | 1 |
| 6 | Characterization of three maize bacterial artificial chromosome libraries toward anchoring of the physical map to the genetic map using high-density bacterial artificial chromosome filter hybridization 显示文摘 | Yim Y S Davis G L Duru N A | 2002 | Plant Physiol2002，130，4： | 1 |
| 7 | Quality of Life impairment, disability and economic burden associated with chronic daily headache, focusing on chronic migraine with or without medication overuse:a systematic review 显示文摘 | Lant6ri-Minet M Duru G Mudge M | 2011 | Cephalalgia2011，31，83： | 1 |
| 8 | Cost-effectiveness of pnemnococcal vaccination of older people:a study in 5 western Europen countries显示文摘 | Ament A Baltussen R Duru G | 2000 | Clin Infect Dis2000，31，： | 1 |
| 9 | Protective Effects of N-Acetylcysteine on Cyclosporine-A-Induced Nephrotoxicity显示文摘 | Mehmet Duru Ahmet Nacar Zafer Y?nden Güven Kuvand?k Mehmet Rami Helvac? Ahmet Ko? Ye?im Akayd?n Hüseyin ?ksüz Sad?k S??üt | 2008 | Renal Failure2008，，4： | 1 |
| 10 | Cost-effectiveness of pneumococcal vaccination of older people: a study in 5 western european countries显示文摘 | Ament A Baltussen R Duru G | 2000 | Clin Infect Dis2000，31，1： | 1 |
| 11 | Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia显示文摘 | ?brahim Kivrak Mehmet Emin Duru Mehmet ?ztürk Nazime Mercan Mansur Harmandar Güla?t? Top?u | 2009 | Food Chemistry2009，，2： | 1 |
| 12 | Atypical left atrial flutter after intraoperative radiofrequency ablation of chronic atrial fibrillation:Successful ablation using three dimensional electroanatomic mapping显示文摘 | Duru F Hindricks G Kottkamp H | 2001 | J Cardiovasc Electrophysiol2001，12，5： | 1 |
| 13 | Heart failure and treatment of ventricular arrhythmias 显示文摘 | Duru F Candinas R | 1999 | Schweiz Rundsch Med Prax1999，88，： | 1 |
| 14 | Atyp ical left atrial flutter after intraoperative radiofrequency ablation of chronic atrial fibrillation:successful ablation using three dimensional electroanatomic mapping显示文摘 | Duru F Hindricks G Kottkamp H | 2001 | J Cardiovasc Electrophysiol2001，12，： | 1 |
| 15 | Cost-Effectiveness of Pneumococcal Vaccination of Older People A Study in 5 Western European Countries显示文摘 | Ament A Baltussen R Duru G | 2000 | Clinical Infec Dis2000，31，2： | 1 |
| 16 | EULAR evidence-based and consensus-based recommendations on the management of medium to high-dose glucocorticoid therapy in rheumatic diseases显示文摘 | N Duru M C van der Goes J W G Jacobs T Andrews M Boers F Buttgereit N Caeyers M Cutolo S Halliday J A P Da Silva J R Kirwan D Ray J Rovensky G Severijns R Westhovens J W J Bijlsma | 2013 | Annals of the Rheumatic Diseases2013，，12： | 1 |
| 17 | Cost- effectiveness of pneumococcal vaccination of older people: a study in 5 western European countries 显示文摘 | Ament A Baltussen R Duru G | 2000 | Clin Infect Dis2000，31，2： | 1 |
| 18 | Race and sex differences in hypertension control in CKD: results from the Kidney Early Evaluation Program (KEEP) 显示文摘 | Duru OK Li S Jurkovitz C Bakris G | 2008 | Am J Kidney Dis2008，51，2： | 1 |
| 19 | Effect of obesity on P-wave dispersion and QT dispersion in women 显示文摘 | Seyferli E Duru M Kuvandik G | 2006 | Int J Obes2006，30，6： | 1 |
| 20 | Effect of weight loss on P wave dispersion in obese subjects显示文摘 | Duru M Seyfeli E Kuvandik G | 2006 | Obesity2006，14，8： | 1 |
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