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| 1 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 2 | SMR forum:managing change in the family firm-issues and strategies显示文摘 | BECKHARD R W DYER JR W G | 1983 | Salon Management Review1983，，： | 1 |
| 3 | Managing Continuity in the Family- Owned Business显示文摘 | BECKHARD R DYER W G JR | 1983 | Organizational Dynam- ics1983，12，2： | 1 |
| 4 | Culture and continuity in family firms 显示文摘 | Dyer W G Jr | 1988 | Family Business Review1988，1，1： | 1 |
| 5 | Examining the ' fmnily effect' on firm performance 显示文摘 | Dyer Jr W | 2002 | Family Business Review2002，，19： | 1 |
| 6 | Managing continuity in the family- owned business显示文摘 | Beckhard Richard and Gibb Dyer Jr | 1983 | Organizational Dynamics1983，12，1： | 1 |
| 7 | Better stories, not better constructs, to generate better theory: a rejoinder to Eisenhardt显示文摘 | Dyer W G Jr Wilkins A L | 1991 | Academy of Management Review1991，16，3： | 1 |
| 8 | Survival by stress modality in patients with a normal myocardial perfusion study显示文摘 | Johnson NP Schimmel DR Jr Dyer SP | 2011 | Am J Cardiol2011，107，7： | 1 |
| 9 | Managing continu- ity in the family - owned business 显示文摘 | Richard Beckhard and Gibb Dyer Jr | 1983 | Organizational Dynamics1983，12，1： | 1 |
| 10 | Managing Continuity in the Family-owned Business 显示文摘 | Richard Beckhard & Gibb Dyer Jr | 1983 | Organizational Dynamics1983，12，1： | 1 |
| 11 | Hostility and urine norepinephrine interact to predict insulin resistance: the VA Normative Aging Study 显示文摘 | Zbang J Niaura R Dyer JR | 2006 | Psychosom Med2006，68，： | 1 |
| 12 | The relationship betweenarterial carbon dioxide tension and end-tidal carbon dioxide tensionin intubated adults with traumatic brain injuries who requiredemergency craniotomies 显示文摘 | Dyer BA White WA Jr Lee D | 2013 | Crit Care Nurs Q2013，36，3： | 1 |
| 13 | Hostility and urine norepi-nephrine interact to predict insulin resistance:the VA NormativeAging Study显示文摘 | Zhang J Niaura R Dyer JR | 2006 | Psychosom Med2006，68，5： | 1 |
| 14 | Quantitation of human immunodeficiency virus type 1 RNA in cell free seminal plasma:comparison of NASBA with Amplicor reverse transcription-PCR amplification and correlation with quantitative culture显示文摘 | Dyer JR Gilliam BL Eron JJ | 1996 | J Virol Methods1996，60，2： | 1 |
| 15 | The family: The missing variable in organizational research显示文摘 | Dyer W G Jr | 2003 | Entrepreneurship Theory and Practice2003，27，4： | 1 |
| 16 | Examining the 'family effect' on firm performance显示文摘 | Dyer W G Jr | 2006 | Family Business Review2006，19，4： | 1 |
| 17 | Culture and comtinuity in family firms显示文摘 | | 1988 | Family Business Review1988，1，1： | 1 |
| 18 | Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus 显示文摘 | Nierman WC Pain A Anderson MJ Wortman JR Kim HS Arroyo J Berriman M Abe K Archer DB Bermejo C Bennett J Bowyer P Chen D Collins M Coulsen R Davies R Dyer PS Farman M Fedorova N Fedorova N Feldblyum TV Fischer R Fosker N Fraser A Garcla JL Garcia MJ Goble A Goldman GH Gomi K Griffith- Jones S Gwilliam R Haas B Haas H Harris D Horiuchi H Huang J Humphray S Jim6nez J Keller N Khouri H Kitamoto K Kobayashi T Konzack S Kulkarni R Kumagai T Lafon A Latgo JP Li W Lord A Lu C Majoros WH May GS Miller BL Mohamoud Y Molina M Monod M Mouyna I Mulligan S Murphy L O'Neil S Paulsen I Pefialva MA Pertea M Price C Pritchard BL Quail MA Rabbinowitsch E Rawlins N Rajandream MA Reichard U Renauld H Robson GD Rodriguez de Cordoba S Rodriguez-Pefia JM Ronning CM Putter S Salzberg SL Sanchez M Sfnchez-Ferrero JC Saunders D Seeger K Squares R Squares S Takeuchi M Tekaia F Turner G Vazquez de Aldana CR Weidman J White O Woodward J Yu JH Fraser C Galagan JE Asai K Machida M Hall N Barrell B Denning DW | 2005 | Nature2005，438，7071： | 1 |
| 19 | Semi-implantable electromagnetic middle ear hearing device for moderate to severe sensorineural hearing loss显示文摘 | HOUGH J V DYER R K Jr MATTHEWS P | 2001 | Otolaryngol Clin North Am2001，34，： | 1 |
| 20 | Stakeholder Identity Orientation Approach to Corporate Social Performance in Family Firms 显示文摘 | BINGHAM J B DYER W G Jr SMITH I | 2011 | Journal of Business Ethics2011，99，2： | 1 |
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