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| 1 | 医院菌群因水平基因转移出现的多药抗药性(英文)显示文摘The frequency and spectrum of antibiotic resistant infections have increased worldwide during the past few decades. This increase has been attributed to a combination of microbial characteristics, the selective pressure of antimicrobial use, and social and technical changes that enhance the transmission of resistant organisms. The resistance is acquired by mutational changer or by the acquisition of resistance-encoding genetic material which is transfered from another bacteria. The spread of antibiotic resistance genes may be causally related to the overuse of antibiotics in human health care and in animal feeds, increased use of invasive devices and procedures, a greater number of susceptible hosts, and lapses in infection control practices leading to increased transmission of resistant organisms. The resistance gene sequences are integrated by recombination into several classes of naturally occurring gene expression cassettes and disseminated within the microbial population by horizontal gene transfer mechanisms: transformation, conjugation or transduction. In the hospital, widespread use of antimicrobials in the intensive care units (ICU) and for immunocompromised patients has resulted in the selection of multidrug-resistant organisms. Methicilin-resistant Staphylococci, vancomycin resistant Enterococci and extended-spectrum betalactamase(ESBL) producing Gram negative bacilli are identified as major phoblem in nosocomial infections. Recent surveillance studies have demonstrated trend towares more seriously ill patients suffering from multidrug-resistant nosocomial infections. Emergence of multiresistant bacteria and spread of resistance genes should enforce the aplication of strict prevention strategies, including changes in antibiotic treatment regimens, hygiene measures, infection prevention and control of horizontal nosocomial transmission of organisms. | Senka DZIDIC Vladimir BEDEKOVIC | 2003 | Acta Pharmacologica Sinica2003，24，6： | 2 |
| 2 | Effects of cleaning duration and water temperature on oxytocin release and milk removal in an automatic milking system显示文摘 | Dzidic A J.Mac' uhova R.M.Bruckmaier | | 0，，： | 1 |
| 3 | New picogram detection system based on a mass spectrometer with an external ionization source at atmospheric pressure 显示文摘 | Homing E C Horning M G Carroll D I Dzidic I Stillwell R N | 1973 | Analytical Chemistry1973，45，6： | 1 |
| 4 | Subpieogram detection system for gas phase analysis based upon atmospheric pressure ionization (API) mass spectrometry显示文摘 | Carroll D Dzidic I Stillwell R Homing M Homing E | 1974 | Analytical Chemistry1974，46，6： | 1 |
| 5 | Improving quantitative real-time RT-PCR reproducibility by boosting primerlinked amplification efficiency显示文摘 | TICHOPAD A DZIDIC A PFAFFL M A | 2002 | Biotechnol Lett2002，24，24： | 1 |
| 6 | Effects of mycophenolic acid (MPA) treatment on expression of Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIgR) mRNA in adult sheep tissues显示文摘 | DZIDIC A MOHR1 A MEYER K | 2004 | Croat Med J2004，45，： | 1 |
| 7 | Townsend dis charge nitric oxide chemical ionization gas chromatography/ mass spectrometry for hydrocarbon analysis of the middle distillates显示文摘 | Dzidic I Petersen H A Wadsworth P A | 1992 | Analytical Chemistry1992，64，19： | 1 |
| 8 | Horizontal gene transfer-emergitag muhi- drug resistance in hospital bacteria显示文摘 | Dzidic S Bedekovie V | 2003 | Aeta Pharmacol Sin2003，24，6： | 1 |
| 9 | Preliminary validation of genomicmicroarrays for routine use in prenatal screening for chromosome imbalance显示文摘 | Mohammed M S Kang J Dzidic N | 2002 | Am J HumGenet2002，71，： | 1 |
| 10 | Horizontal gene transfer-emerging multi- drug resistance in hospital bacteria显示文摘 | Dzidic S Bedekovic V | 2003 | Aeta Pharmacol Sin2003，24，6： | 1 |
| 11 | Determination of naphthenic acids in California crudes and refinery wastewaters by fluoride ion chemical ionization mass spectrometry显示文摘 | DZIDIC I SOMERVILLE A C RAIA J C | 1988 | Analytical Chemistry1988，60，13： | 1 |
| 12 | Horizontal gene transfer-emerging multidrug resistance in hospital bacteria显示文摘 | Dzidic S Bedekovi V | 2003 | Acta Pharmacol Sin2003，24，6： | 1 |
| 13 | Horizontal gene transferem erging mul-tidrug resistance in hospital bacteria显示文摘 | Dzidic S Bedekovi V | 2003 | A cta Phamacol Sin2003，24，： | 1 |
| 14 | Determination of naphthenic acids in California crudes by mass spectrometry显示文摘 | Dzidic I Somerville A C Raia J C | 1988 | Anal Chem1988，60，： | 1 |
| 15 | Determination of Naphthenic Acids in California Crudes and Refinery Wastewaters by Fluoride Ion Chemical Ionization Mass Spectrometry显示文摘 | Dzidic I Somerville AC Raia JC | 1988 | Anal Chem1988，，60： | 1 |
| 16 | Identification and quantification of carbazole and benzocarbazole homologues in clarified slurry oils by and ammonia chemical ionization GC-MS 显示文摘 | DZIDIC I BALICKI M D HART H V | 1988 | Fuel1988，67，8： | 1 |
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