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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Guidelines on the diagnosis,investigation and management chronic lymphocytic leukemia显示文摘 | OSCIER D DEARDEN C EREN E | 2012 | Br J Haematol2012，159，： | 1 |
| 3 | Decreased HDL-de- pendent paraoxonase and arylesterase enzyme activity May indicate a worse prognosis in multiple myeloma显示文摘 | Ellidag HY Aydin O Eren E | 2014 | Asian Pac J Cancer Prev2014，15，22： | 1 |
| 4 | Monocyte derived dendritic cell responses in common variable immunodeficiency 显示文摘 | Scott-Taylor TH Green MR Eren E | 2004 | Clin Exp Immunol2004，138，3： | 1 |
| 5 | An investigation of Cu(II) adsorption by raw and acid-activated bentonite: A combined potentiometric, thermodynamic, XRD, IR, DTA study显示文摘 | EREN E AFSIN B | 2008 | J Hazard Mater2008，151，23： | 1 |
| 6 | Surgical Approach to Extensive Hidradenitis Suppurativa in the Perineal/ Perianal and Gluteal Regions显示文摘 | Balik E Eren T Bulut T | 2009 | World J Surg2009，33，： | 1 |
| 7 | The use of the harmonic scapel vs conventional knot tying for vessel ligation in thyroid surgery显示文摘 | Allan E Eren Berber Ebru Morkoyun | 2002 | Arch Surg2002，137，2： | 1 |
| 8 | Second and third cardiac valve reoperations: factors influencing death and long-term survival显示文摘 | Toker ME Eren E Guler M | 2009 | Tex Heart Inst J2009，36，6： | 1 |
| 9 | Investigation of a basic dye adsorption from aqueous solution onto raw and pre-treated bentonite surfaces显示文摘 | Eren E Msin B | 2010 | Dyes and Pigments2010，76，1： | 1 |
| 10 | Evaluation of nutritional risk on admission to the general surgery department显示文摘 | Haldun G Eren E Recep A | 2008 | Bratisl Lek Listy2008，109，2： | 1 |
| 11 | Local delivery of chitosan/ VEGF siRNA nanoplexes reduces angiogenesis and growth of breast cancer in vivo 显示文摘 | Salva E Kabasakal L Eren F | 2012 | Nucleic acid therapeutics2012，22，1： | 1 |
| 12 | Arabidopsis HMA2,a divalent heavy metal-transporting P1B-type ATPase,is involved in cytoplasmic Zn^2+ homeostasis显示文摘 | EREN E ARUELLO J M | 2004 | Plant Physiology2004，136，： | 1 |
| 13 | Evaluation of nutritional risk on admission to the general surgery department 显示文摘 | Haldun G Eren E Recep A | 2008 | Bratisl Lek Listy2008，109，2： | 1 |
| 14 | Biochemical markers of bone turnover and bone mineral density in patients with beta-thalassaemia major显示文摘 | Eren E Yilmaz N | | 0，，01： | 1 |
| 15 | Psychiatric disorders and epige- netics显示文摘 | Eren Kodak E and Ertu~rul A | 2012 | Turk Psikiyatri Derg2012，23，2： | 1 |
| 16 | Diagnostic value of C -reactive protein in patients with angiographically documentedcoronary heart disease 显示文摘 | Eren E Yilmaz N Pence S | 2002 | Aeta Medic(Hradec Kralove)2002，45，4： | 1 |
| 17 | Robust,object-based high-resolution image reconstruction from low-resolution video显示文摘 | EREN P E SEZAN M I TEKALP A M | 1997 | IEEE Trans on Image Processing1997，6，10： | 1 |
| 18 | Calmodulin kinase Ⅱ inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein显示文摘 | Khoo M S Grueter C E Eren M | | 0，，02： | 1 |
| 19 | Oxidative stress and ischemi- a-modified albumin in chronic ischemic heart failure 显示文摘 | Ellidag HY Eren E Yilmaz N | 2014 | Redox Rep2014，19，3： | 1 |
| 20 | Reactive oxygen species scavenging activity during periodontal mucoperiosteal healing:An experimental study in dogs显示文摘 | Sakalliolu U Aliyev E Eren Z | 2005 | Archives of Oral Biology2005，50，12： | 1 |
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