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| 1 | 利用腰围身高比预测有雄激素缺乏症的老年男性体内血清睾酮水平显示文摘老年男性血清睾酮的下降可能部分是由肥胖引起的,但是,还不能确定哪些肥胖相关的参数与睾酮水平最密切相关。我们研究过伴有雄激素缺乏症但健康状况良好的老年男性的年龄、肥胖和睾酮水平的关系。本研究中,我们从社区中募集了54岁以上无痛症或其他严重疾病的非吸烟男性做横向研究分析,测定身高,体重和腰围,并计算体质指数(BMI)和腰围身高比(WHt)。收集两个早上的血液样本,测量总睾酮,性激素结合球蛋白和促黄体激素。计算游离睾酮(cFT)。并对上述指标与肥胖参数之间的关系进行多元线性凹归分析。207名54-86岁之间的男性参与了此次研究。单因素分析结果表明腰围身高比与睾酮和游离睾酮的相关性明显高于体重和腰吲或体质指数。另外,对总睾酮和游离睾酮来说,体重和腰围以及身高都有重要意义(所有的P均小于0.05),身高值中加入体重和腰围值后,导致体重和腰用以及身高的回归系数都增加了,其中腰围呈负相关,身高呈正相关。总之,腰围身高比是预测健康但有雄激素缺乏症的老年男性的睾酮和游离睾酮最好的体质指标。 | Carolyn A Allan Roger E Peverill Boyd JG Strauss Elise A Forbes Robert I McLachlan | 2011 | Asian Journal of Andrology2011，13，3： | 3 |
| 2 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 3 | CD 64 distinguishes macrophages from dendritic cells in the gut and reveals the T h1‐inducing role of mesenteric lymph node macrophages during colitis显示文摘 | Samira Tamoutounour Sandrine Henri Hugues Lelouard Béatrice de Bovis Colin de Haar C. Janneke van der Woude Andrea M. Woltman Yasmin Reyal Dominique Bonnet Dorine Sichien Calum C. Bain Allan McI. Mowat Caetano Reis e Sousa Lionel F. Poulin Bernard Malisse | 2012 | Eur J Immunol2012，，12： | 2 |
| 4 | Neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma: The need for patient-centered research显示文摘Pancreatic ductal adenocarcinoma is an aggressive cancer with high recurrence rates following surgical resection.While adjuvant chemotherapy improves survival,a significant proportion of patients are unable to initiate or complete all intended therapy following pancreatectomy due to postoperative complications or poor performance status.The administration of chemotherapy prior to surgical resection is an alternative strategy that ensures its early and near universal delivery as well as improves margin-negative resection rates and potentially improves long-term survival outcomes.Neoadjuvant therapy is increasingly being recommended to patients with pancreatic ductal adenocarcinoma,however,patient-centered research on its use is lacking.In this review,we highlight opportunities to focus research efforts in the domains of patient preferences,patient-reported outcomes,patient experience,and survivorship.Novel research in these areas may identify relevant barriers and facilitators to the use of neoadjuvant therapy thereby increasing its utilization,improve shareddecision making for patients and providers,and optimize the experience of those undergoing neoadjuvant therapy. | Jordan M Cloyd Allan Tsung John Hays Celia E Wills John FP Bridges | 2020 | World Journal of Gastroenterology2020，26，4： | 2 |
| 5 | Aedes albopictus (Diptera: Culicidae) oviposition response to organic infusions from common flora of suburban Florida显示文摘 | Obenauer P J Allan S A Kaufman P E | 2010 | Journal of Vector Ecology2010，，2： | 2 |
| 6 | Recommendations for using opioids in chronic non-cancer pain显示文摘 | Kalso E Allan L Dellemijn PLI | 2003 | European Journal of Pain2003，7，5： | 1 |
| 7 | The potential biocontrol agent Pseudomonas antimicrobica inhibits germination of conidia and outgrowth of Botrytis cinerea 显示文摘 | Walker R Innes C Allan E | 2001 | Letters in Applied Microbiology2001，32，： | 1 |
| 8 | An ELISA for the detection of Bacillus subtilis L-form bacteria confirms their symbiosis in strawberry显示文摘 | FERGUSON C M J BOOTHL N A ALLAN E J | 2000 | Lett in Appl Microbiol2000，31，： | 1 |
| 9 | Communication between eph- rinB2 and EphB4 within the osteoblast lineage 显示文摘 | Martin T J Allan E H Ho P W | 2010 | Adv Exp Med Biol2010，658，： | 1 |
| 10 | The interleukin-l system:an attractive and viable therapeutic target in neurodegenerative disease显示文摘 | Allan SM Pinteaux E | 2003 | Curt Drug Target CNS Neurol Disord2003，2，5： | 1 |
| 11 | Gender and Crime:Toward A Gendered Theory of Female Offending显示文摘 | STEFFENSMEIER D ALLAN E | 1996 | Annual Review of Sociology1996，22，： | 1 |
| 12 | Genetic variation in height and volume of loblolly pine open-pollinated families during canopy closure显示文摘 | Svensson J C McKeand S E Allan H L | 1999 | Silvae Genetica1999，48，34： | 1 |
| 13 | Patterns of weight gain in pregnant women with and without gestational diabetes mellitus:an observational study显示文摘 | Stewart Z A Wallace E M Allan CA | | 0，，05： | 1 |
| 14 | Agronomic comparisons between Rhtl and Rht2 semidwarf genes in winter wheat 显示文摘 | Allan R E | 1989 | Crop Science1989，29，： | 1 |
| 15 | Mediator ofinjury in neurotrauma : intracellular signal transduction andgene expression显示文摘 | Bazan N G Rodriguez de Turco E B Allan G | 1995 | J Neurotrauma1995，12，5： | 1 |
| 16 | Control of Taenia solium taeniasis/cysticercosis:From research towards implementation显示文摘 | Pawlowski Z Allan J Sarti E | 2005 | International Journal for Parasitology2005，35，1112： | 1 |
| 17 | Synthesizing US river restoration efforts 显示文摘 | BERNHARDT E S PALMER M ALLAN J | 2005 | Science2005，308，5722： | 1 |
| 18 | Recommendations for using opioids in chronic non - cancer pain 显示文摘 | Kalso E Allan L Dellemijn PLI | 2003 | European Journal of Pain2003，7，5： | 1 |
| 19 | The use of the harmonic scapel vs conventional knot tying for vessel ligation in thyroid surgery显示文摘 | Allan E Eren Berber Ebru Morkoyun | 2002 | Arch Surg2002，137，2： | 1 |
| 20 | A Component Architecture for Highperformence Scientific Computing 显示文摘 | David E Bernholdt Benjamin A Allan Robert Armstrong | 2006 | International Journal of High Performance Computing Aplications2006，20，8： | 1 |
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