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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Vortex-induced vibrations of flexible bridges显示文摘 | Ehsan F Scanlan R H | 1990 | Journal of Engineering Mechanics1990，116，： | 1 |
| 3 | Vortex-induced vibrations of flexible bridges 显示文摘 | Ehsan F Scanlan R H | 1990 | Journal of Engineering Mechanics1990，116，6： | 1 |
| 4 | Measuring the efficiency ofthird party reverse logistics provider in supply chain bymulti objective additive network DEA model显示文摘 | Ehsan M Majid A Reza F S | 2015 | Internation-al journal of shipping and transport logistics2015，7，1： | 1 |
| 5 | Wind-induced motions of deer isle bridge 显示文摘 | Kumarasena T Scanlan R H Ehsan F | 1991 | Journal of Structural Engineering ASCE1991，117，11： | 1 |
| 6 | Additive effects of Na+ and Cl ' ions on barley growth under salinity stress显示文摘 | Ehsan Tv Foad F Stewa C | 2011 | Journal of Experimental Botany2011，62，6： | 1 |
| 7 | Vortex-induced vibrations of flexible bridges显示文摘 | EHSAN F SCANLAN R H | 1990 | Journal of Engineering Mechanics1990，116，6： | 1 |
| 8 | Vortex-induced vibrations of flexible bridges 显示文摘 | Ehsan F Scanlan R H | 1990 | Journal of Engineering Mechanics ASCE1990，116，6： | 1 |
| 9 | Energy saving in HVAC systems using nanofluid 显示文摘 | Ehsan F Mohammad S Hossien N S | 2011 | Applied Thermal Engineering2011，31，89： | 1 |
| 10 | Vortex-induced vibrations of flexible bridges 显示文摘 | Ehsan F Scanlan R H | 1990 | Journal of Engineering Mechan- ics1990，116，6： | 1 |
| 11 | Vortex-Induced Vibrations of flexible bridg- es 显示文摘 | Ehsan F Scanlan R H | 1990 | Journal of Engineering Mechanics1990，116，6： | 1 |
| 12 | Vortex-induced vibrations of flexible bridges显示文摘 | EHSAN F SCANLAN R H | 1990 | Journal of Engineering Mechan- ics1990，116，： | 1 |
| 13 | Vortex-induced vibrations of flexible bridges显示文摘 | Ehsan F Seanlan R H | 1990 | Journal of Engineering Mechanics1990，116，6： | 1 |
| 14 | Vortex-induced vibra- tions of flexible bridges 显示文摘 | EHSAN F SCANLANR H | 1990 | Journal of Engineering Mechanics1990，116，16： | 1 |
| 15 | Evaluation of the enclose proximal anastomosis device in coronary artery bypass grafting 显示文摘 | Sary F Aranki Prem S Shekar Afshin Ehsan | 2005 | Ann Thorac Surg2005，80，3： | 1 |
| 16 | Vortex-induced vibrations of flexible bridges 显示文摘 | EHSAN F SCANLAN R | 1990 | Journal of Engineering Mechanics1990，116，6： | 1 |
| 17 | Mo-nitoring crack propagation in reinforced concrete shearwalls by acoustic emission 显示文摘 | ALIREZA F EHSAN D N SALVATORE S | 2012 | Journal of StructuralEngineering2012，139，12： | 1 |
| 18 | Vortex-induced vibration of flexible bridges显示文摘 | EHSAN F SCANLAN R H | 1990 | Journal of Engineering Mechanics1990，116，6： | 1 |
| 19 | Vortex-induced vibrations of flexiblebridges显示文摘 | Ehsan F Scanlan R H | 1990 | Journal of Engineering Mechanics1990，116，6： | 1 |
| 20 | Explaining the ex- change rate pass -through in different prices显示文摘 | Ehsan U C Hamid F Dalia S H | 2005 | Journal of International Economics2005，65，2： | 1 |
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