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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implica tions for cell based vascular therapy显示文摘 | Griese D P Ehsan A Melo L G Kong D Zhang L Mann M J | 2003 | Circulation2003，108，： | 1 |
| 3 | The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells显示文摘 | WEINBERG M S VILLENEUVE L M EHSAN! A | 2006 | RNA2006，，12： | 1 |
| 4 | Risk-constrained strategic bidding of GenCos considering demand response显示文摘 | Kazemi M Mohammadi-Natloo B Ehsan M | 2014 | IEEE Transactions onPowerSystems2014，30，1： | 1 |
| 5 | Longterm cyclical in vivo Roading increases cartilage proteoglycan content in a spatially specific manner:an infrared microspeetroscopic imaging and polarized light microscopy study 显示文摘 | Ehsan S Howard L Shannila M | 2006 | Arthri Res2006，8，： | 1 |
| 6 | Possibilistic evaluation of distributed generations impacts on distribution networks显示文摘 | Soroudi A Ehsan M Caire R | 2011 | IEEE Transactions on Power Systems2011，26，4： | 1 |
| 7 | Design recommendations for bond of GFRP rebar to concrete 显示文摘 | EHSAN M R SAADATMANESH H TAO S | 1996 | Journal of Structural Engineering1996，，2： | 1 |
| 8 | A genetic-based Tabu search algorithm for optimal DG allocation in distribution networks显示文摘 | Gandomkar M Vakilian M Ehsan M | 2005 | Electric Power Components and Systems2005，33，： | 1 |
| 9 | Measuring the efficiency ofthird party reverse logistics provider in supply chain bymulti objective additive network DEA model显示文摘 | Ehsan M Majid A Reza F S | 2015 | Internation-al journal of shipping and transport logistics2015，7，1： | 1 |
| 10 | Integral resonant control for suppression of resonance in piezoelectric micro-actua- tor used in precision servomechanism 显示文摘 | Abdullah A M Ehsan K Charanjit S B | 2013 | Mechatronics2013，23，1： | 1 |
| 11 | High-Performance Low-Cost Rogowski Transducers and Accompanying Circuitry 显示文摘 | EHSAN A J RICHARD M | 2007 | IEEE Transactions on Instrumentation and Measurement2007，56，3： | 1 |
| 12 | A genetic-based tabu search algorithm for optimal DR allocation in distributed networks显示文摘 | Gandomkar M Vakilian M Ehsan M | 2005 | Electric Power Components & Systems Trans2005，33，12： | 1 |
| 13 | Efficien- cy and dynamic performance of Digital DisplacementTM hydraulic transmission in tidal current energy converters 显示文摘 | PAYNE G KIPRAKIS A EHSAN M | 2007 | Power and Energy2007，221，2： | 1 |
| 14 | The effects of nanoscale expansive agents on the mechanical properties of non-shrink cement-based composites:the influence of nano-MgO addition显示文摘 | Reza M Ehsan T N Tayebeh P | 2013 | Composites:Part B2013，55，： | 1 |
| 15 | Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control显示文摘 | Eman A El-ghoroury Hala M Raslan Ehsan A Badawy Gamila S El-Saaid Mervat H Agybi Ibrahem Siam Sohair I Salem | 2009 | Blood Coagulation & Fibrinolysis2009，，4： | 1 |
| 16 | A torque and speed coupling hybrid drivetrain -architecture, control and simulation 显示文摘 | Gao Y Ehsan M | 2006 | Transactions on Power Electronics2006，21，3： | 1 |
| 17 | A numerical study of flow and temperature fields in circular tube heat exchanger with elliptic vortex generators 显示文摘 | Ehsan M L Mofid G B Reza M | 2008 | Thermal Science2008，12，2： | 1 |
| 18 | Cooperative Routing in Static Wireless Networks显示文摘 | Ehsan K A Jinane A Eytan M | 2007 | IEEE Trans on Communications2007，55，11： | 1 |
| 19 | Genetic-based tabu search algorithm for optimal DG allocation in distribution networks 显示文摘 | GANDOMKAR M VAKILIAN M EHSAN M A | 2007 | Electric Power Components and Systems2007，33，12： | 1 |
| 20 | Genetic-based tabu search algorithm for optimal DG allocation in distribution networks 显示文摘 | GANDOMKAR M VAKILIAN M EHSAN M A | 2007 | Electric Power Components and Systems2007，33，12： | 1 |
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