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| 1 | Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways显示文摘Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways. | Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid | 2017 | Chinese Journal of Natural Medicines2017，15，7： | 2 |
| 2 | Adaptive wavdet thresholding for image denoising and eompression显示文摘 | Chang S G Ein Yu Vetlerli M | 2000 | IEEE Trans Image Processing2000，9，9： | 1 |
| 3 | Appendicitis in the child with a ventriculo-peritoneal shunt:a 30-year review显示文摘 | Ein SH Miller S Rutka JT | 2006 | Pediatr Surg2006，41，7： | 1 |
| 4 | The surface fractal dimension of the soil-pore interface as measured by image analysis显示文摘 | Dathe A Eins S Niemeyer J | 2001 | Geoderma2001，103，： | 1 |
| 5 | Epidemiologic investigation of an outbreak of goose parvovirus infection in Sweden显示文摘 | JANSSON D S FEINST EIN R KARDI V | 2007 | Avian Dis2007，51，2： | 1 |
| 6 | Pediatric malignant pheochromocytoma显示文摘 | Weitzman S Thomer P | 1994 | J Ped Surg1994，29，11： | 1 |
| 7 | The role of peritoneal drains in treatment of perforated necrotizing enterocolitis:recommendations from recent experience显示文摘 | Ahmed T Ein S Morre A | 1998 | J Pediatr Surg1998，33，： | 1 |
| 8 | Acute effects of tea consumption on at- tention and mood显示文摘 | Ein? ther S J Martens V E | 2013 | Am J Clin Nutr2013，98，6： | 1 |
| 9 | Optimization and validation of a rapid high resolution T 1-w 3 d FLASH water excitation MRI see quence for the quantitative assessment of articular cartilage volume and thickness显示文摘 | Glaser C Faber S Eckst ein F | 2001 | Magn Reson Imaging2001，19，2： | 1 |
| 10 | Li-ion battery electrolyte formulated for low-temperature applications显示文摘 | EIN ELI Y THOMAS S R CHADHA R | 1997 | J Electrochem Soc1997，144，3： | 1 |
| 11 | Unsuccessful air-enema reduction of intussusception:is a second attempt worthwhile显示文摘 | Sandier A D Ein S H Connolly B | 1999 | Pediatr Surg Int1999，15，3： | 1 |
| 12 | Signal quality of biometry in silicone oil-filled eyes using partial coherence laser interferometry 显示文摘 | Diet]ein TS Roessler G Luke C Dinslage S Roters S Jacobi PC | 2005 | J Cataract Refract Surg2005，31，5： | 1 |
| 13 | The surface fractal dimension of the soil-pore interface as measured by image analysis显示文摘 | DATHE A EINS S NIEMEYER J GEROLD G | 2001 | Geoderma2001，，27： | 1 |
| 14 | Study of solid- liq- uid mixing in agitated tanks through electrical resistance tomography 显示文摘 | Hosseini S Patel D Ein - Mozaffari F | 2010 | Chem Eng Sci2010，65，4： | 1 |
| 15 | Six thousand three hundred sixty-one pediatric inguinal hemias: a 35-year review 显示文摘 | Ein S H Njere I Ein A | 2006 | J Pediatr Surg2006，41，5： | 1 |
| 16 | Ethylmethyl- carbonate as a promising solvent for Li-ion recharge- able batteries显示文摘 | Eineli Y Thomas S R Koch V | 1996 | Journal of the Electrochemical Soci- ety1996，142，12： | 1 |
| 17 | Pediatric malignant pheochromocytoma显示文摘 | Ein SH Weitzman S Thorner P | 1994 | J Pediatr Surg1994，29，9： | 1 |
| 18 | The challenge of innovation implementation显示文摘 | KI EIN K T SORRA T S | 1996 | Academy of Management Review1996，21，4： | 1 |
| 19 | Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi - stage mass spectrometry显示文摘 | EIN S WANG D YANG D | 2007 | Anal Chim Acta2007，599，1： | 1 |
| 20 | 显示文摘 | Dathe A Eins S Niemeyer J | 2001 | Geoderma2001，103，： | 1 |
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