|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 3 | CCR7 ligands SLC/6Ckine/Exodus-2/TCA-4 and CKb-11/MIP-3b/ELC are chemoattractants for CD56(+) CD16(-) NK cells and late stage lymphoid progenitors显示文摘 | Kim CH Pelus LM Appelbaum EK | 1999 | Cell Immunol1999，193，2： | 1 |
| 4 | High-resolution diffusion-weighted 3D MRI,using diffusion-weighted driven-equilibrium (DW-DE) and multishot segmented 3D-SSFP without navigator echoes显示文摘 | Jeong EK Kim SE Parker DL | 2003 | Magn Reson Med2003，50，4： | 1 |
| 5 | New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid显示文摘 | Kim EK Park CS Chung WY | 2002 | AJR2002，178，： | 1 |
| 6 | Pathological roles of MAPK signaling pathways in human diseases显示文摘 | Kim EK Choi EJ | 2010 | Biochim Biophys Acta2010，1802，4： | 1 |
| 7 | Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity 显示文摘 | Kim JM Lee EK Park G | 2010 | Free Radic Res2010，44，4： | 1 |
| 8 | Effect of transcranial direct current stimulation on motor recovery in patients with subacute stroke 显示文摘 | Kim DY Lim JY Kang EK | 2010 | Am J Phys Med Rehabil2010，89，11： | 1 |
| 9 | UltrasonographicCharacteristics of Subacute Granulomatous Thyroiditis 显示文摘 | Park SY Kim EK Kim MJ | 2006 | Korean J Radiol2006，7，4： | 1 |
| 10 | Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult 显示文摘 | Kim HH Kim JC Park EK | 2011 | Hepatobiliary Pancreat Dis Int2011，10，6： | 1 |
| 11 | Pathological roles of MAPK signaling pathways in human diseases显示文摘 | Kim EK Choi EJ | 2010 | Biochim Biophys Acta2010，1802，4： | 1 |
| 12 | Sonographic features of the follicular variant of papillary thyroid carcinoma显示文摘 | Yoon JH Kim EK Hong SW | | 0，，10： | 1 |
| 13 | Pathological roles of MAPK signaling pathways in human diseases显示文摘 | Kim EK Choi EJ | 2010 | Biochim Biophys Acta2010，1802，4： | 1 |
| 14 | Effect of High DoseRosuvastatin Loading before Primary Percutaneous CoronaryIntervention on Infarct Size in Patients with ST-SegmentElevation Myocardial Infarction 显示文摘 | Kim JW Yun KH Kim EK | 2014 | Korean Circ J2014，44，2： | 1 |
| 15 | Application of the Thyroid Imaging Reporting and Data System in thyroid uhrasonography interpretation by less experienced physicians显示文摘 | Ko SY Lee HS Kim EK | 2014 | Ultrasonography2014，33，1： | 1 |
| 16 | Positive predictive values of sonographic features of solid thyroid nodule 显示文摘 | Hong YJ Son EJ Kim EK | 2010 | Clin hnaging2010，34，2： | 1 |
| 17 | A membrane-bound form of IL-4 enhances proliferation and antigen presentation of CD40-activated human B cells显示文摘 | Park JY Yoon SH Kim EK | 2008 | Immunol Lett2008，116，1： | 1 |
| 18 | Induction of cell death in human macrophages by a highly virulent Korean isolate of Mycobacterium tuberculosis and the virulent strain H37Rv显示文摘 | Sohn H Lee KS Kim SY Shin DM Shin SJ Jo EK Park JK Kim HJ | 2009 | Scand J Immunol2009，69，1： | 1 |
| 19 | Laparoscopic treatment of choledocholithiasis u-sing modified biliary stents显示文摘 | Kim EK Lee SK | 2004 | Surg Endosc2004，18，2： | 1 |
| 20 | The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes显示文摘 | Jung SB Yang CS Lee JS Shin AR Jung SS Son JW Har- ding CV Kim HJ Park JK Paik TH Song CH Jo EK | 2006 | Infect Immun2006，74，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员