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| 1 | Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis显示文摘The nonalcoholic fatty liver disease(NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a wide histological spectrum ranging from benign simple steatosis to non-alcoholic steatohepatitis(NASH). Sustained inflammation in the liver is critical in this process. Hepatic macrophages, including liver resident macropaghes(Kupffer cells), monocytes infiltrating the injured liver, as well as specific lymphocytes subsets play a pivotal role in the initiation and perpetuation of the inflammatory response, with a major deleterious impact on the progression of fatty liver to fibrosis. During the last years, Th17 cells have been involved in the development of inflammation not only in liver but also in other organs, such as adipose tissue or lung. Differentiation of a na?ve T cell into a Th17 cell leads to pro-inflammatory cytokine and chemokine production with subsequent myeloid cell recruitment to the inflamed tissue. Th17 response can be mitigated by T regulatory cells that secrete anti-inflammatory cytokines. Both T cell subsets need TGF-β for their differentiation and a characteristic plasticity in their phenotype may render them new therapeutic targets. In this review, we discuss the role of the Th17 pathway in NAFLD progression to NASH and to liver fibrosis analyzing different animal models of liver injury and human studies. | Carla Melisa Chackelevicius Sabrina Eliana Gambaro Claudio Tiribelli Natalia Rosso | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Clinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis:Differences and similarities显示文摘AIM:To investigate the prevalence of the clinical parameters of insulin resistance and diabetes in patients affected by chronic hepatitis C(CHC) or chronic hepatitis B(CHB) . METHODS:We retrospectively evaluated 852 consecutive patients(726 CHC and 126 CHB) who had undergone liver biopsy.We recorded age,sex,ALT,type 2 diabetes and/or metabolic syndrome(MS) ,body mass index(BMI) ,and apparent disease duration(ADD) . RESULTS:Age,ADD,BMI,prevalence of MS and diabetes in patients with mild/moderate liver fibrosis were significantly higher in CHC.However,the degree of steatosis and liver fibrosis evaluated in liver biopsies did not differ between CHC and CHB patients.At multivariate analysis,age,sex,BMI,ALT and diabetes were independent risk factors for liver fibrosis in CHC,whereas only age was related to liver fibrosis in CHB. We also evaluated the association between significant steatosis(>30%) and age,sex,BMI,diabetes,MS and liver fibrosis.Diabetes,BMI and liver fibrosis were associated with steatosis>30%in CHC,whereas only age and BMI were related to steatosis in CHB. CONCLUSION:These data may indicate that hepatitis C virus infection is a risk factor for insulin resistance. | Marcello Persico Mario Masarone Vincenzo La Mura Eliana Persico Francesco Moschella Monica Svelto Savino Bruno Roberto Torella | 2009 | World Journal of Gastroenterology2009，15，4： | 8 |
| 3 | Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000显示文摘AIM: To review gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy. To look at gut microflora features in oncology children.METHODS: We selected studies published after year 2000, excluding trials on transplanted pediatric patients. We searched English language publications in MEDLINE using the keywords: 'gastrointestinal infection AND antineoplastic chemotherapy AND children', 'gastrointestinal infection AND oncology AND children', 'liver infection AND antineoplastic chemotherapy AND children', 'liver abscess AND chemotherapy AND child', 'neutropenic enterocolitis AND chemotherapy AND children', 'thyphlitis AND chemotherapy AND children', 'infectious diarrhea AND children AND oncology', 'abdominal pain AND infection AND children AND oncology', 'perianal sepsis AND children AND oncology', 'colonic pseudo-obstruction A N D o n c o l o g y A N D c h i l d A N D c h e m o t h e r a p y ', 'microflora AND children AND malignancy', 'microbiota AND children AND malignancy', 'fungal flora AND children AND malignancy'. We also analysed evidence from several articles and book references.RESULTS: Gastrointestinal and liver infections represent a major cause of morbidity and mortality in children undergoing antineoplastic chemotherapy. Antineoplastic drugs cause immunosuppression in addition to direct toxicity, predisposing to infections, although the specific risk is variable according to disease and host features. Common pathogens potentially induce severe diseases whereas opportunistic microorganisms may attack vulnerable hosts. Clinical manifestations can be subtle and not specific. In addition, several conditions are rare and diagnostic process and treatments are not standardized. Diagnosis may be challenging, however early diagnosis is needed for quick and appropriate interventions. Interestingly, the source of infectionin those children can be exogenous or endogenous. Indeed, mucosal damage may allow the penetrance of endogenous microbes towards the bowel wall and their translocation into the bloodstream. However, only limited knowledge of intestinal dysbiosis in oncology children is available. CONCLUSION: The diagnostic work-up requires a multimodal approach and should be implemented(also by further studies on new biomarkers) for a prompt and individualized therapy. | Elio Castagnola Eliana Ruberto Alfredo Guarino | 2016 | World Journal of Gastroenterology2016，22，25： | 6 |
| 4 | Management of portopulmonary hypertension:New perspectives显示文摘Portopulmonary hypertension(PPHTN)is a known complication of cirrhosis.Moderate-to-severe PPHTN implies an extremely poor prognosis.It occurs in 5%-10%of patients referred for liver transplantation(LT),and probably with an higher incidence in patients with large portosystemic shunts.Patients with moderate-tosevere pulmonary hypertension have been previously excluded from LT because of the extremely high surgical risk and since the post-transplant outcome reported was poor.Recently,new perspectives in the management of patients with portopulmonary hypertension are emerging.In fact,some pulmonary vasoactive drugs have become routine in the treatment of patients with idiopathic pulmonary hypertension.These drugs,particularly epoprostenol,have been recently introduced in the treatment of patients with PPHTN,and have been shown to be effective in reducing pulmonary artery pressure as well as pulmonary vascular resistances.Furthermore,recent studies seem to demonstrate that treatment with pulmonary vasoactive drugs could allow liver transplantation with acceptable surgical risks and excellent survival.Although there are not large series nor prospective studies addressing this topic,the clinical scenario of patients with PPHTN seems to be positively changing. | Luigi Mancuso Francesca Scordato Michela Pieri Eliana Valerio Andrea Mancuso | 2013 | World Journal of Gastroenterology2013，19，45： | 5 |
| 5 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 6 | Novel fibrin-fibronectin matrix accelerates mice skin wound healing显示文摘Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing.About 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN fibrin.Three dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts.HUVECs in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN fibrin.Relative toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced healing.This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing. | Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo | 2020 | Bioactive Materials2020，5，4： | 5 |
| 7 | Layered double hydroxide(LDH)-based materials:A mini-review on strategies to improve the performance for photocatalytic water splitting显示文摘The high energy demand we currently face in society and the subsequent large consumption of fossil fuels cause its depletion and increase the pollution levels.The quest for the production of clean energy from renewable and sustainable sources remains open.The conversion of solar energy into hydrogen via the water-splitting process,assisted by pho tores pons ive semiconductor catalysts,is one of the most promising technologies.Significant progress has been made on water splitting in the past few years and a variety of photocatalysts active not only under ultra-violet(UV) light but especially with the visible part of the electromagnetic spectrum have been developed.Layered double hydroxides(LDH)-based materials have emerged as a promising class of nanomaterials for solar energy applications owing to their unique layered structure,compositional flexibility,tunable bandgaps,ease of synthesis and low manufacturing costs.This review covers the most recent research dedicated to LDH materials for photocatalytic water-splitting applications and encompasses a range of synthetic strategies and post-modifications used to enhance their performance.Moreover,we provide a thorough discussion of the experimental conditions crucial to obtaining improved photoactivity and highlight the impact of some specific parameters,namely,catalysts loading,cocatalysts,sacrificial agents,and irradiation sources.This review provides the necessary tools to select the election technique for adequately enhancing the photoactivity of LDH and modified LDH-based materials and concludes with a critical summary that outlines further research directions. | Hanane Boumeriame Eliana S.Da Silva Alexey S.Cherevan Tarik Chafik Joaquim L.Faria Dominik Eder | 2022 | Journal of Energy Chemistry2022，31，1： | 5 |
| 8 | Iron Mobilization and Mineralogical Alterations Induced by Iron-Deficient Cucumber Plants (Cucumis sativus L.) in a Calcareous Soil显示文摘Dicotyledons cope with ion(Fe) shortage by releasing low-molecular-weight organic compounds into the rhizosphere to mobilize Fe through reduction and complexation mechanisms. The effects induced by these root exudates on soil mineralogy and the connections between Fe mobilization and mineral weathering processes have not been completely clarified. In a batch experiment, we tested two different kinds of organic compounds commonly exuded by Fe-deficient plants, i.e., three organic acids(citrate, malate, and oxalate)and three flavonoids(rutin, quercetin, and genistein), alone or in combination, for their ability to mobilize Fe from a calcareous soil and modify its mineralogy. The effect of root exudates on soil mineralogy was assessed in vivo by cultivating Fe-deficient and Fe-sufficient cucumber plants(Cucumis sativus L.) in a RHIZOtest device. Mineralogical analyses were performed by X-ray powder diffraction. The batch experiment showed that citrate and, particularly, rutin(alone or combined with organic acids or genistein)promoted Fe mobilization from the soil. The combinations of rutin and organic acids modified the soil mineralogy by dissolving the amorphous fractions and promoting the formation of illite. These mineralogical alterations were significantly correlated with the amount of Fe mobilized from the soil. The RHIZOtest experiment revealed a drastic dissolution of amorphous components in the rhizosphere soil of Fe-deficient plants, possibly caused by the intense release of phenolics, amino acids, and organic acids, but without any formation of illite. Both batch and RHIZOtest experiments proved that exudates released by cucumber under Fe deficiency concurred to the rapid modification(on a day-scale) of the mineralogy of a calcareous soil. | Concetta Eliana GATTULLO Youry PII Ignazio ALLEGRETTA Luca MEDICI Stefano CESCO Tanja MIMMO Roberto TERZANO | 2018 | Pedosphere2018，28，1： | 3 |
| 9 | Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome显示文摘 | Laura Zanotti Eliana Bignotti Stefano Calza Elisabetta Bandiera Giuseppina Ruggeri Claudio Galli Germana Tognon Monica Ragnoli Chiara Romani Renata A. Tassi Luigi Caimi Franco E. Odicino Enrico Sartori Sergio Pecorelli Antonella Ravaggi | 2012 | Clinical Chemistry and Laboratory Medicine2012，，12： | 2 |
| 10 | Relationship between head and neck cancer therapy and some genetic endpoints显示文摘Head and neck cancer(HNC) is the sixth most common human malignancy worldwide. The main forms of treat ment for HNC are surgery, radiotherapy(RT) and che motherapy(CT). However, the choice of therapy de pends on the tumor staging and approaches, which are aimed at organ preservation. Because of systemic RT and CT genotoxicity, one of the important side effects is a secondary cancer that can result from the activity of radiation and antineoplastic drugs on healthy cells Ionizing radiation can affect the DNA, causing single and double-strand breaks, DNA-protein crosslinks and oxidative damage. The severity of radiotoxicity can be directly associated with the radiation dosimetry and the dose-volume differences. Regarding CT, cisplatin is stil the standard protocol for the treatment of squamous cell carcinoma, the most common cancer located in theoral cavity. However, simultaneous treatment with cisplatin, bleomycin and 5-fluorouracil or treatment with paclitaxel and cisplatin are also used. These drugs can interact with the DNA, causing DNA crosslinks, double and single-strand breaks and changes in gene expression. Currently, the late effects of therapy have become a recurring problem, mainly due to the increased survival of HNC patients. Herein, we present an update of the systemic activity of RT and CT for HNC, with a focus on their toxicogenetic and toxicogenomic effects. | Eliana Maria Minicucci Glenda Nicioli da Silva Daisy Maria Fávero Salvadori | 2014 | World Journal of Clinical Oncology2014，5，2： | 2 |
| 11 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 12 | Filling the Gaps to Solve the Extensin Puzzle显示文摘Extensins (EXT ) 是高度重复的植物 O-glycoproteins 要求几 translational 以后修正(PTM ) 在植物房间墙中变得功能。首先,他们是连续脯氨酸残余上的 hydroxylated;然后 ? 他们是 hydroxyproline 上的 O-glycosylated ? 并且丝氨酸。在进 apoplast 的分泌物以后, O-glycosylated EXT 形成 inter-Tyr 和 intra-Tyr 连接组织的一个三度空间的网络。最近的研究在要求处理 EXT 的酶的机械的鉴定取得了重要进步,它包括 prolyl 4-hydroxylases, glycosyltransferases, papain 类型半胱氨酸 endopeptidases,和 peroxidases。EXT 充满植物纸巾 ? 并且在很快扩展根头发和花粉试管是特别地重要的,它以一种极的方式成长。在 EXT PTM 的小面值硬币影响快成长的房间,尽管位于这条规定下面的分子的机制是未知的。在这评论,我们在整个能分泌的小径,在房间墙中的 EXT 集会,和包含 Catharanthus roseus 房间表面传感器的可能的察觉到机制在我们 EXT 修正的理解加亮最近的进展像受体的 kinases ? 在在 apoplast 和血浆膜的细胞质的方面之间的接口定位了。 | Eliana Marzol Cecilia Borassi Mauro Bringas Ana Sede Diana Rosa Rodriguez Garcia Luciana Capece Jose M. Estevez | 2018 | Molecular Plant2018，11，5： | 2 |
| 13 | Who trusts others?显示文摘 | Alberto Alesina Eliana La Ferrara | 2002 | Journal of Public Economics2002，，2： | 2 |
| 14 | Association of chronic hepatitis C with recurrent brief depression显示文摘 | Mauro G. Carta Jules Angst Maria Francesca Moro Gioia Mura Maria Carolina Hardoy Cinzia Balestrieri Luchino Chessa Giancarlo Serra Maria Eliana Lai Patrizia Farci | 2012 | Journal of Affective Disorders2012，，2： | 2 |
| 15 | Specific consumption of liquid biofuels in gasoline fuelled engines显示文摘 | Renato Catalufia Rosngela da Silva Eliana Weber de Menezes | 2008 | Fuel2008，87，1516： | 1 |
| 16 | Quantification of Listeria monoeytogenes in minimally processed leafy vegetables using a combined method based on enrichment and 16SrRNAreal-time PCR显示文摘 | Maria A O Eliana G R Alzira M B | 2010 | Food Microbiology2010，，27： | 1 |
| 17 | Quantification of Listeria monocytogenes in minimally processed leafy vegetables using a combined method based on enrichment and 16S rRNA real-time PCR显示文摘 | Maria Aparecida de Oliveira Eliana Guimar?es Abeid Ribeiro Alzira Maria Morato Bergamini Elaine Cristina Pereira De Martinis | 2009 | Food Microbiology2009，，1： | 1 |
| 18 | New materials for polymer electrolytes 显示文摘 | PIERCARLO M ELIANA Q CORRADO T | 2000 | Solid State Ionics2000，135，： | 1 |
| 19 | 氦气有中度抗炎作用,但在人体缺血-再灌注损伤中没有内皮保护作用显示文摘背景惰性气体氦气没有麻醉作用但对心肌有预处理的作用。我们假设氦气吸入可以对人体前臂的缺血.再灌注内皮功能不全有保护作用。方法这是一项交叉设计的研究,包括8例健康男性受检者。每个志愿者在前臂缺血15分钟时被随机分成吸氦气或不吸氦气组。氦气的呼气末浓度达50vol%。从缺血前15分钟开始吸氦气直到再灌注后5分钟(“氦气状态”)。充血反应是一种一氧化氮生物利用率和内皮功能的标记物。应用静脉阻塞体积描记术在再灌注的15分钟和30分钟时测定前臂充血反应。再灌注期用流式细胞计测定促炎症标记物CDllb、ICAM-1、PSGL-1和Dselectin(CD62L)在白细胞上的表达以及P-selectin(CD62P)、PSGL-1和CD42b在血小板上的表达。结果缺血。再灌注持续地降低再灌注15分钟和30分钟时阻塞后的内皮依赖性充血反应。围缺血期吸入50vol%氦气不能改善阻塞后充血反应。氦气降低促炎症标记物CDllb和ICAM-1在白细胞上的表达,也降低促凝标记物CD42b和PSGL-1在血小板上的表达。结论虽然吸入氦气可以消除缺血后的炎性反应,但本研究表明50vol%氦气不能保护人在体内皮。内皮是所有重要器官的主要组成成分。这与七氟醚的研究结果相反,七氟醚在低浓度、亚麻醉浓度下有人体内皮的保护作用。 | Eliana Lucchinetti, PhD Johannes Wacker, MD Christian Maurer, MD Marius Keel, MD Luc Hairter, PhD Kathrin Zaugg, MD, PhD Michael Zaugg, MD 周全红(译) | 2012 | 麻醉与镇痛2012，8，1： | 1 |
| 20 | Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses Asthma-like responses via nitric oxide synthase 2 activity显示文摘 | RODRIGUEZ D ALEXANDRE C K ELIANA L F M | 2003 | The Journal of Immunology2003，171，： | 1 |
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