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| 1 | 半胱氨酰白三烯拮抗剂治疗儿童哮喘(英文)显示文摘哮喘是一种梗阻性肺疾病,以支气管收缩、持续性气道炎症和气道重塑为特征。临床上常用吸入皮质激素和β2受体拮抗剂辅佐治疗儿童哮喘,但这些药物疗法的治疗效果不是很理想,而且不适当的大剂量皮质激素会导致骨质疏松,生长迟缓和青光眼等严重副作用。口服抗白三烯剂是一种治疗儿童哮喘的新方法。白三烯是由花生四烯酸通过5 脂肪氧化酶途径由肥大细胞、嗜酸粒细胞和肺泡巨噬细胞合成的脂质。它通过与气道平滑肌上的CysLT1受体结合参与哮喘的炎症反应而引起支气管收缩。最近的研究表明,半胱氨酰白三烯可以介导上皮下胶原沉着和平滑肌肥大增生,从而导致不可逆的气道重塑和气道阻塞。实验研究和初步的临床研究显示,白三烯拮抗剂孟鲁司特辅助治疗儿童哮喘,可以减少皮质激素和β2拮抗剂的用量,预防气道重塑、减轻哮喘症状。然而,抗白三烯药物的疗效还需通过随机、双盲和多中心的临床研究得到进一步证实。 | Robert KLEINMAN Marco MURA Ming-Yao LIU | 2005 | 中国当代儿科杂志2005，7，5： | 13 |
| 2 | Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis显示文摘Portal vein thrombosis(PVT) is a frequent complication in cirrhosis, particularly in advanced stages of the disease. As for general venous thromboembolism, risk factors for PVT are slow blood flow, vessel wall damage and hypercoagulability, all features of advanced cirrhosis. Actually, the old dogma of a hemorrhagic tendency in cirrhosis has been challenged by new laboratory tools and the clinical evidence that venous thrombosis also occurs in cirrhosis. The impaired hepatic synthesis of both pro- and anticoagulants leads to a rebalanced hemostasis, more liable to be tipped towards thrombosis or even bleeding. Conventional anticoagulant drugs(low molecular weight heparin or vitamin K antagonists) may be used in cirrhosis patients with PVT, particularly in those eligible for liver transplantation, to prevent thrombosis progression thus permitting/facilitating liver transplant. However, several doubts exist on the level of anticoagulation achieved as estimated by coagulation tests, on the efficacy of treatment monitoring and on the correct timing for discontinuation in non-transplant candidates, while in transplant candidates there is expert consensus on continuing anticoagulation until transplantation. The recent introduction of direct acting oral anticoagulant drugs(DOACs) in other clinical settings generates much interest on their possible application in patients with cirrhosis and PVT. However, DOACs were not evaluated yet in patients with liver disease and cannot be recommended for the present time. | Massimo Primignani Giulia Tosetti Vincenzo La Mura | 2015 | World Journal of Hepatology2015，7，29： | 13 |
| 3 | Cirrhosis and portal hypertension: The importance of risk stratification, the role of hepatic venous pressure gradient measurement显示文摘Portal hypertension is the main prognostic factor in cirrhosis. The recent emergence of potent antiviral drugs and new algorithm of treatment for the management of complications due to portal hypertension have sensibly changed our perception of cirrhosis that can be now considered as a multistage liver disease whose mortality risk can be reduced by a tailored approachfor any stage of risk. Experts recommend to move toward a pathophysiological classification of cirrhosis that considers both structural and functional changes. The hepatic venous pressure gradient HVPG, is the reference gold standard to estimate the severity of portal hypertension in cirrhosis. It correlates with both structural and functional changes that occur in cirrhosis and carries valuable prognostic information to stratify the mortality risk. This article provides a general overview of the pathophysiology and natural course of cirrhosis and portal hypertension. We propose a simplified classification of cirrhosis based on low, intermediate and high mortality stage. The prognostic information provided by HVPG is presented according to each stage. A comparison with prognostic models based on clinical and endoscopic variables is discussed in order to evidence the additional contribute given by HVPG on top of other clinical and instrumental variables widely used in clinical practice. | Vincenzo La Mura Antonio Nicolini Giulia Tosetti Massimo Primignani | 2015 | World Journal of Hepatology2015，7，4： | 10 |
| 4 | Clinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis:Differences and similarities显示文摘AIM:To investigate the prevalence of the clinical parameters of insulin resistance and diabetes in patients affected by chronic hepatitis C(CHC) or chronic hepatitis B(CHB) . METHODS:We retrospectively evaluated 852 consecutive patients(726 CHC and 126 CHB) who had undergone liver biopsy.We recorded age,sex,ALT,type 2 diabetes and/or metabolic syndrome(MS) ,body mass index(BMI) ,and apparent disease duration(ADD) . RESULTS:Age,ADD,BMI,prevalence of MS and diabetes in patients with mild/moderate liver fibrosis were significantly higher in CHC.However,the degree of steatosis and liver fibrosis evaluated in liver biopsies did not differ between CHC and CHB patients.At multivariate analysis,age,sex,BMI,ALT and diabetes were independent risk factors for liver fibrosis in CHC,whereas only age was related to liver fibrosis in CHB. We also evaluated the association between significant steatosis(>30%) and age,sex,BMI,diabetes,MS and liver fibrosis.Diabetes,BMI and liver fibrosis were associated with steatosis>30%in CHC,whereas only age and BMI were related to steatosis in CHB. CONCLUSION:These data may indicate that hepatitis C virus infection is a risk factor for insulin resistance. | Marcello Persico Mario Masarone Vincenzo La Mura Eliana Persico Francesco Moschella Monica Svelto Savino Bruno Roberto Torella | 2009 | World Journal of Gastroenterology2009，15，4： | 8 |
| 5 | Intrahepatic vascular changes in non-alcoholic fatty liver disease: potential role of insulin-resistance and endothelial dysfunction显示文摘Metabolic syndrome is a cluster of several clinical conditions characterized by insulin-resistance and high cardiovascular risk. Non-alcoholic fatty liver disease is the liver expression of the metabolic syndrome, and insulin resistance can be a frequent comorbidity in several chronic liver diseases, in particular hepatitis C virus infection and/or cirrhosis. Several studies have demonstrated that insulin action is not only relevant for glucose control, but also for vascular homeostasis. Insulin regulates nitric oxide production, which mediates to a large degree the vasodilating, antiinflammatory and antithrombotic properties of a healthy endothelium, guaranteeing organ perfusion. The effects of insulin on the liver microvasculature and the effects of IR on sinusoidal endothelial cells have been studied in animal models of non-alcoholic fatty liver disease. The hypotheses derived from these studies and the potential translation of these results into humans are critically discussed in this review. | Marcos Pasarín Juan G Abraldes Eleonora Liguori Beverley Kok Vincenzo La Mura | 2017 | World Journal of Gastroenterology2017，23，37： | 6 |
| 6 | The “Brain Stress Timing” phenomenon and other misinterpretations of randomized clinical trial on aneurysmal subarachnoid hemorrhage显示文摘Clipping and coiling are currently the two alternatives in treatment of ruptured cerebral aneurysms. In spite of some meritorious analysis, further discussion is helpful to understand the actual state of art. Retreatment and rebleeding rates clearly favors clipping, although short-term functional outcome seems to be beneficial for clipping, while this different is not such if we perform the comparison at a longer follow up. Longterm follow ups and cost analysis are mandatory to have a clear view of the current picture in treatment of subarachnoid hemorrhage. Treatment strategy should be made by a multi-disciplinary team in accredited centers with proficient experience in both techniques. | Rafael Martinez-Perez Natalia Rayo Agustin Montivero Jorge Marcelo Mura | 2019 | Neural Regeneration Research2019，14，8： | 5 |
| 7 | Numerical study on fatigue crack propagation behaviors in lubricated rolling contact显示文摘The surface-initiated Rolling Contact Fatigue(RCF)including pitting and micro-pitting is one of the key issues affecting the reliability of tribological components such as gears and bearings used in various devices.In this work,a surface-initiated crack Finite Element(FE)model which considers the effect of lubricant on crack faces was developed to investigate surface-initiated RCF using an automatic crack propagating Python script.Different lubricating states,initial crack parameters and loading conditions were simulated to analyze the evolution of crack propagation and the Stress Intensity Factors(SIFs).The RCF crack propagation path and life were predicted by employing the Maximum Tangential Stress(MTS)criterion coupled with the Paris’s law.A typical RCF failure is predicted in the numerical simulation.Results reveal that the lubricating pressurization dominates the surface-initiated RCF.In addition,the initial crack angle has a significant effect on the RCF crack propagation path and the fatigue life. | Haifeng HE Huaiju LIU Caichao ZHU Andrea MURA | 2021 | Chinese Journal of Aeronautics2021，34，9： | 4 |
| 8 | Use of non-selective beta blockers in cirrhosis:The evidence we need before closing(or not) the window显示文摘Non selective beta blockers(NSBBs)are used in primary and secondary prophylaxis of portal hypertensionrelated bleeding in patients with cirrhosis.The efficacy of NSBBs treatment is predicted by hemodynamic response in term of reduction of the hepatic venouspressure gradient(HVPG)below 12 mm Hg or at least20%of the basal value.Nevertheless a relevant number of patients who do not achieve this HVPG reduction during NSBBs therapy do not bleed during follow up;this evidence suggests an additional non-hemodynamic advantage of NSBBs treatment to modify the natural history of cirrhosis.Recent studies have questioned the efficacy and safety of NSBBs in patients with advanced stage of liver disease characterized by refractory ascites and/or spontaneous bacterial peritonitis.These studies have suggested the existence of a defined and limited period to modify the natural history of cirrhosis by NSBBs:the'window hypothesis'.According with this hypothesis,patients with cirrhosis benefit from the use of NSBBs from the appearance of varices up to the development of an advanced stage of cirrhosis.Indeed,in patients with refractory ascites and/or spontaneous bacterial peritonitis the hemodynamic effects of NSBBs may expose to a high risk of further complications such as renal insufficiency and/or death.Methodological concerns and contrasting results counterbalance the evidence produced up to now on this issue and are the main topic of this editorial. | Vincenzo La Mura Giulia Tosetti Massimo Primignani Francesco Salerno | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 9 | Neoadjuvant therapy in pancreatic adenocarcinoma: A meta-analysis of phase II trials显示文摘 | M. Mura Assifi Xuyang Lu Guido Eibl Howard A. Reber Gang Li O. Joe Hines | 2011 | Surgery2011，，3： | 3 |
| 10 | 经皮冠状动脉成形术中的冠状动脉破裂原因分析显示文摘目的:探讨冠状动脉成形术中冠状动脉破裂的可能原因。方法:对所有介入治疗前的靶病变行定性和定量造影分析,并选择在发生冠状动脉破裂前最近一次的血管内超声(IVUS)图像进行分析。结果:在5个心脏介入中心总共1 506例经皮冠状动脉成形术(PCI)患者中,发生冠状动脉破裂15例(1.0%),其中6例与操作导丝相关,1例与单纯球囊扩张相关,8例与支架植入相关。6例与导丝相关的破裂均由亲水涂层或中等硬度导丝所致,靶病变包括3例闭塞、4例偏心和3例分叉病变。与球囊或支架相关冠状动脉破裂包括6例偏心、6例中等至严重钙化病变。有血管内超声分析的5例,其病变偏心率均小于0.4,钙化弓在42~109度。除了单纯球囊破裂病例,在所有支架植入导致的破裂,球囊/管腔比值均超过1.3。所有与导丝相关冠状动脉破裂属于EllisⅡ级,与球囊或支架相关的2例属Ⅱ级,7例属Ⅲ级。结论:导丝相关的冠状动脉破裂常发生在采用亲水涂层或中等硬度导丝对偏心、分叉或闭塞病变进行操作;球囊或支架相关冠状动脉破裂经常与球囊尺寸过大或压力过大有关,常发生在偏心和伴钙化的病变处。 | 邱朝晖 Kataoka Toru 郭新贵 Kobayashi Yoshiki Nishioka Hiroki 张煜 Sakamoto Kazuo Yoshi mura Takayoshi Shi mada Kenei Yoshikawa Junichi | 2010 | 中国临床医学2010，17，4： | 3 |
| 11 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 12 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 13 | Laparoscopic versus open distal pancreatectomy: a single-institution case-control study显示文摘 | Sanket Sharad Mehta Ghalia Doumane Thibault Mura David Nocca Jean-Michel Fabre | 2012 | Surgical Endoscopy2012，，2： | 2 |
| 14 | 基于齿轮精度等级的直齿轮副静态传动误差预测方法显示文摘本文提出一种基于齿轮精度等级的直齿轮副静态传动误差预测方法,该方法综合考虑了加工误差、安装误差、轮齿变形以及齿廓修形的影响。首先,分别建立了根据ISO齿轮精度等级生成误差齿廓的离散齿轮模型,轮齿变形模型,以及传动误差模型;随后,将上述三个模型进行耦合,从而实现直齿轮副传动误差的预测。对比分析文献中实验结果与本文预测结果,验证了该预测方法的正确性。基于一系列仿真算例,研究了加工误差、安装误差、轮齿变形以及齿廓修形对静态传动误差的影响规律。此外,还研究了加工误差和安装误差对时变啮合侧隙的影响规律,以及受载条件下重合度的变化规律。结果显示,该方法可有效预测不同齿轮精度等级下直齿轮副静态传动误差范围。预测结果可为齿轮设计参数的选择和齿轮系统设计阶段传动性能的优化提供参考。 | 刘昶 石万凯 Francesca Maria CURÀ Andrea MURA | 2020 | Journal of Central South University2020，27，11： | 2 |
| 15 | Streptomyces griseochromogenes菌株milbemycin生物合成基因簇的筛选显示文摘经BamHI酶切的柯氏质粒pku4 0 3与MboⅠ部分消化并经碱性磷酸酶处理的Streptomycesgriseochromogenes染色体DNA片段相连接 ,体外包装后 ,转化大肠杆菌E .coliJM1 0 8,挑取转化子1 1 5 2个 ,构建Streptomycesgriseochromogenes的基因文库。分别以avermectin聚酮体合成酶 (PKS)的酰基转移酶基因 (AT)、酮基合成酶基因 (KS)及参与avermectin生物合成的内酯化酶基因(aveE)、C5 O 甲基转移酶基因 (aveD)为探针 ,利用菌落原位杂交、核酸杂交和以烯酰基还原酶基因(ER)引物的PCR扩增等手段 ,从文库中筛选出 2 4个阳性克隆。根据克隆DNA之间的重叠关系 ,将阳性克隆分为 7组 ,这 | 阎浩林 IKEDA Haruo MURA Satoshi | 2001 | 沈阳药科大学学报2001，18，5： | 2 |
| 16 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 17 | Association of chronic hepatitis C with recurrent brief depression显示文摘 | Mauro G. Carta Jules Angst Maria Francesca Moro Gioia Mura Maria Carolina Hardoy Cinzia Balestrieri Luchino Chessa Giancarlo Serra Maria Eliana Lai Patrizia Farci | 2012 | Journal of Affective Disorders2012，，2： | 2 |
| 18 | Analysis of a load application point in spline coupling teeth显示文摘研究目的:研究理想和偏差条件下接触压力分布导致的花键联接渐开线齿的合力位置。创新要点:分别给出了额定条件和两轴偏移条件下载荷直径和节径的偏差,并分析了荷载点齿轮刚度和接触压力分布的影响。研究方法:运用有限元模型分别分析在理想条件和两轴偏移条件下花键联接的影响。重要结论:验证了传统上应用于径节的花键联接啮合齿接触合力的近似法。在额定条件下,载荷直径和径节的偏差随载荷等级的增加而增加。在0.08 mm两轴偏移模型下,有限元法获得的结果与理论径节的最大偏差为2.94%。一般的,在理想联接和两轴偏移花键联接条件下,载荷直径和径节的偏差并不大。径节处载荷和实际荷载点所获得的刚度偏差接近15%。荷载点变化的影响与轴向压力分布相关,即该参数受荷载点位置的影响。 | Francesca CURA Andrea MURA | 2014 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2014，15，4： | 2 |
| 19 | Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery显示文摘 | Gennaro Galizia Eva Lieto Michele Orditura Paolo Castellano Anna La Mura Vincenzo Imperatore Margherita Pinto Anna Zamboli Ferdinando Vita Francesca Ferraraccio | 2007 | World Journal of Surgery2007，，7： | 2 |
| 20 | 径流涡轮叶尖间隙对叶片振动的影响研究显示文摘由于对高效、高响应性涡轮增压器的大量需求,径流涡轮叶片的高周疲劳已成为涡轮增压器损坏的最常见原因。叶尖间隙是主导叶尖泄漏涡演化的关键参数,并影响叶片表面的气动激振力,其对叶片振动的影响不可忽略。本文采用单向流固耦合数值方法,研究无叶径流涡轮叶尖间隙对叶片振动的影响。结果表明,叶片振幅随间隙增大成“V形”变化趋势。广义能量分析表明,“V形”趋势由压力谐波分量的幅值在叶片表面的分布所决定。流场分析进一步表明,压力谐波分量的幅值在叶片压力面和吸力面的分布均受叶尖泄漏涡影响,但两者的机理不同。 | 潘镭 杨名洋 Shouta Murae Wataru Sato Naoto Shimohara Akihiro Yamagata | 2021 | 风机技术2021，63，3： | 2 |
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