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| 1 | Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy显示文摘AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.METHODS: The study included three age and gendermatched groups of 20 cataract patients with no diabetes or additional disease(Group C), 20 cataract patients with diabetes and no retinopathy(Group DM+C), and 20 cataract patients with diabetic retinopathy(Group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid profile.Phacoemulsification and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the operation.The plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent assays.RESULTS: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(P<0.05 for all parameters tested).The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C(P<0.001, P=0.004).No statistically significant difference was determined in the aqueous adiponutrin levels in three groups.The plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C(both P=0.001).The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C(P=0.001, P<0.001).CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin resistance.The measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development. | Fatih Cem Gül Sabiha Güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 3 |
| 2 | Development of EST ‐ SSR markers for diversity and breeding studies in opium poppy显示文摘 | Hatice ?elale Ibrahim ?elik Visam Gültekin Jens Allmer Sami Do?anlar Anne Frary | 2013 | Plant Breed2013，，3： | 1 |
| 3 | Biosorption of reactive blue 4 dyeby native and treated fungus Phanerocheate chrysosporium:Batchand continuous flow system studies 显示文摘 | BAYRAMOLU G (ELIK G ARICA M Y | 2006 | J Hazardous Mat2006，137，： | 1 |
| 4 | Second-line gemcitabine-based chemotherapy regimens improve overall 3-year survival rate in patients with malignant pleural mesothelioma: a multicenter retrospective study显示文摘 | Hasan Mutlu ?eyda Gündüz Halit Karaca Abdullah Büyük?elik Yasemin Benderli Cihan Abdülsamet Erden Zeki Akca Hasan ?enol Co?kun | 2014 | Medical Oncology2014，，8： | 1 |
| 5 | Extended vertical trapezius myocutaneous flap in head and neck reconstruction as a salvage procedure显示文摘 | U(g)urlu K Oz(c)elik D Hüthüt I | | 0，，02： | 1 |
| 6 | Apolipoprotein A5 polymorphisms in Turkish population:association with serum lipid profile and risk of ischemic stroke显示文摘 | Can Demird(o)(g)sen B (s)ahin E Türkano(g)lu (o)z(c)elik A | 2012 | Molecular Biology Reports2012，39，10： | 1 |
| 7 | Effects of Subchronic Exposure to Phosalone on Oxidative Stress and Histopathological Alterations in Common Carp (Cyprinus carpio, L., 1758)显示文摘 | Hasan Kaya Ekrem?anver ?elik Mert Gürkan Sevdan Y?lmaz Mehmet Akbulut | 2013 | Journal of Toxicology and Environmental Health, Part A2013，，14： | 1 |
| 8 | DoesHelicobacter pylori-induced gastritis enhance food-stimulated insulin release?显示文摘 | Dr. ?zer A?bay MD Aykut Ferhat ?elik MD Sadi Gündo?du MD | 1996 | Digestive Diseases and Sciences1996，，7： | 1 |
| 9 | Synthesis of a novel dithiooxamide-formaldehyde resin and its application to the adsorption andseparation of silver ions显示文摘 | ELIK Z GLFEN M AYDIN A O | 2010 | J Hazard Mater2010，174，13： | 1 |
| 10 | Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms显示文摘BACKGROUND: The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease(COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase(PON) enzyme that protects low density lipoproteins(LDL) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192 R, L55 M genes of patients with COPD.METHODS: DNAs extraction was obtained from blood samples of 50 patients diagnosed with COPD and 50 patients as a control group who were presented to emergency clinic. Genotypes were obtained with polymerase chain reaction(PCR) and AIw I and Hsp92 II restriction enzymes were used for Q192 R and L55 M polymorphisms, respectively. Analysis of data was done with the Chi-square test and Fisher's exact test.RESULTS: A statistically significant difference in Q192 R polymorphism was found between the COPD patients and the control group(P=0.05). There was no statistically significant difference in L55 M polymorphisms between the patient and control groups(P>0.05). Q192 R polymorphism was significantly correlated with the PON1 gene and cigarette smoking; however other risk factors did not show any significant correlation with this polymorphism. Though L55 M polymorphism was significantly correlated with family history and tuberculosis, there was no significant correlation with other risk factors.CONCLUSION: We believe that more studies are needed to study the correlation of L55 M polymorphism with other factors. | ?ükrü Gürbüz Mustafa Y?ld?z Murat Kara Kür?at Kargün Mehtap Gürger Metin Ate??elik ?mer Do?an Alata? | 2015 | World Journal of Emergency Medicine2015，6，3： | 1 |
| 11 | A new flotation scheme for a difficult-to-float coal using pitch additive in dry grinding显示文摘 | G Ate?ok M.S ?elik | 2000 | Fuel2000，，12： | 1 |
| 12 | In vitrosusceptibility,tolerance and MLS resistancephenotypes of Group C and Group G streptococciisolated in Turkey between 1995 and 2002显示文摘 | ERGIN A ERCIS S HASC ELIK G | 2003 | Int JAntimicrob Agents2003，22，2： | 1 |
| 13 | Determination of grafting compatibility of grapevine with elec- trophoretic methods显示文摘 | GOKBAYRAKA Z SOYLEMEZO LU G AKKURTT M ELIK H | 2007 | Scientia Horticulturae2007，113，4： | 1 |
| 14 | Association Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease Complexity in Patients With Acute Coronary Syndrome显示文摘 | Mustafa Tar?k A?a? Levent Korkmaz G?khan ?avu?o?lu Ay?e Gül Karadeniz Süret A?a? Hüseyin Bektas Hakan Erkan Mustafa Oguz Varol Mehmet Bulent Vatan Zeydin Acar ümit Mente?e ?ükrü ?elik | 2013 | Angiology2013，，8： | 1 |
| 15 | Antioxidant activity and total phenolic, organic acid and sugar content in commercial pomegranate juices显示文摘 | Filiz Tezcan Mine Gültekin-?zgüven Tu?ba Diken Beraat ?z?elik F. Bedia Erim | 2009 | Food Chemistry2009，，3： | 1 |
| 16 | Studies on accumulation of uranium by fungus Lentinus sajorcaju显示文摘 | BAYRAMOGLU G :ELIK G ARICA M Y | 2006 | Journal of Hazardous Materials2006，136，2： | 1 |
| 17 | Treatment and follow-up of pulmonary alveolar microlithiasis with disodium editronate: radiological demonstration显示文摘 | U?ur ?z?elik Meltem Gülsün Ayhan G??men Macit Ar?yürek Nural Kiper Deniz Anadol Nazan ?obano?lu | 2002 | Pediatric Radiology2002，，5： | 1 |
| 18 | Vapoeoolant spray vs lidocaine/prilecalne cream for reducing the pain of venipuncture in hemodial-ysispatients : a randomized,placebo-controlled,crossover study 显示文摘 | Elik G Ozbek 0 YUmaz M | 2011 | Int J Medsci2011，8，7： | 1 |
| 19 | Impaired subjective sleep quality in irritable bowel syndrome patients with a T ype D personality显示文摘 | Osman Y?ld?r?m Aytekin Al?elik Fatih Canan Gülali Akta? Mustafa Sit Ahsen ???i Abdullah Yal??n Edip E Y?lmaz | 2013 | Sleep and Biological Rhythms2013，，2： | 1 |
| 20 | 显示文摘 | IJN G R ~ELIK S BOZKURT A | 2013 | Curr Appl Phys2013，13，8： | 1 |
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