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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | Gastric cancer: Current status of lymph node dissection显示文摘D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC. | Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，10： | 29 |
| 3 | Charater- ization of antibody responses to annual influenza vaccination over four years in a healthy elderly population 显示文摘 | Elizabeth M Gardner Erica D Berstein Sandra Dran | 2001 | Vaccine2001，32，19： | 1 |
| 4 | A distributed system-level diagnosis for arbitrary network topologies显示文摘 | SAMPATHR ANTON T D ERICA Z | 1995 | IEEE Transactions on Computers1995，44，5： | 1 |
| 5 | Charaterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population显示文摘 | Elizabeth MG Erica DB Sandra D | 2001 | Vaccine2001，19，2001： | 1 |
| 6 | Preimplantation exposure of mouse embryos to pal-mitic acid results in fetal growth restriction followed bycatch-up growth in the offspring显示文摘 | Emily S Jungheim Erica D Louden Maggie M-Y Chi | 2011 | Biology of Repro-duction2011，85，： | 1 |
| 7 | Effects of hand hygiene cam- paigns on incidence of laboratory-confirmed influenza and absenteeism in sehoolchildrens, cairo, egypt 显示文摘 | MAHA T SALMA A ERICA D | 2011 | Emerg Infect Dis2011，17，4： | 1 |
| 8 | Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis显示文摘 | Richard P G ten Broek Yama Issa Evert J P van Santbrink Nicole D Bouvy Roy F P M Kruitwagen Johannes Jeekel Erica A Bakkum Maroeska M Rovers Harry van Goor | 2013 | BMJ (oct )2013，，031： | 1 |
| 9 | Adhesion awareness: a nationwide survey of gynaecologists显示文摘 | Tess Meuleman Marc H.F. Schreinemacher Harry van Goor Erica A. Bakkum P. Joep D?rr | 2013 | European Journal of Obstetrics and Gynecology2013，，： | 1 |
| 10 | Rapid dehydration of grape berries dampens the post-ripening transcriptomic program and the metabolite profile evolution显示文摘The postharvest dehydration of grape berries allows the concentration of sugars and other solutes and promotes the synthesis of metabolites and aroma compounds unique to high-quality raisin wines such as the passito wines made in Italy.These dynamic changes are dependent on environmental parameters such as temperature and relative humidity,as well as endogenous factors such as berry morphology and genotype,but the contribution of each variable is not well understood.Here,we compared berries subjected to natural or accelerated dehydration,the latter driven by forced air flow.We followed the evolution of transcript and metabolite profiles and found that accelerated dehydration clearly dampened the natural transcriptomic and metabolomic programs of postharvest berries.We found that slow dehydration over a prolonged duration is necessary to induce gene expression and metabolite accumulation associated with the final quality traits of dehydrated berries.The accumulation of key metabolites(particularly stilbenoids)during postharvest dehydration is inhibited by rapid dehydration conditions that shorten the berry life time. | Sara Zenoni Alessandra Amato Erica D’Incà Flavia Guzzo Giovanni Battista Tornielli | 2020 | Horticulture Research2020，7，1： | 1 |
| 11 | Adsorption of Hexadecyltrimethylammonium Bromide to Mica:Nanometer-Scale Study of Binding-Site Competition Effects显示文摘 | William A D Erica J W | 1999 | SPE1999，，： | 1 |
| 12 | A decomposition analysis of CO/emissions in the United States 显示文摘 | Ferdinand V Ferdinand D F Erica S | 2010 | Applied Economics Letters2010，17，10： | 1 |
| 13 | In vitro micropropagation of Primula scotic:a rare Scottish plant显示文摘 | Erica E Benson J E D anaher | 2000 | Biodiversity and Conservation2000，9，： | 1 |
| 14 | Cultural Factors in Social Anxiety: A Comparison of Social Phobia Symptoms aand Taijin Kyofusho显示文摘 | Dinnel D L Erica E H N | 1997 | Journal of Anxiety Disorders1997，11，2： | 1 |
| 15 | Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47显示文摘 | David R Soto-Pantoja Erica V Stein Natasha M Rogers Maryam Sharifi-Sanjani Jeffrey S Isenberg David D Roberts | 2013 | Expert Opinion on Therapeutic Targets2013，，1： | 1 |
| 16 | In vitro micropropagation of Primula scotic:a rare Scottish plant显示文摘 | Erica E Benson J anaher E D | 2000 | Biodiversity and Conservation2000，，9： | 1 |
| 17 | Impact of bubble and free surface oxygen transfer on diffused aeration systems 显示文摘 | Connie D DeMoyer Erica L Schierholz John S Gulliver | 2003 | Water Research2003，37，8： | 1 |
| 18 | Metabolic determinants of defibrillation显示文摘 | Bruce B Lerman Erica D Engelstein | 1995 | Circulation1995，91，： | 1 |
| 19 | Rethinking loyalty 显示文摘 | Bob M Basak D G Erica N (2012) | 2012 | Annals of Tourism Research2012，39，2： | 1 |
| 20 | A decomposi tion analysis of CO2 emissions in the United States显示文摘 | FERDINAND V FERDINAND D F ERICA S | 2010 | Applied Economics Letters2010，17，10： | 1 |
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