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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Irritable bowel syndrome: A concise review of current treatment concepts显示文摘Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, 'classic' treatments for IBS as well as newer agents and 'alternative' therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients. | Geoffrey C Wall Ginelle A Bryant Michelle M Bottenberg Erik D Maki rew R Miesner | 2014 | World Journal of Gastroenterology2014，20，27： | 5 |
| 3 | Phosphorus Use Efficiency of Bio-Based Fertilizers:Bioavailability and Fractionation显示文摘Although to date some technologies producing bio-based phosphorus(P) fertilizers have been proposed and implemented, the efficient use of the recovered products is still limited due to legislative constraints and lack of insights in the P release with time and in the corresponding mechanisms. The aim of this work was to evaluate the fertilizer performance in terms of P release and use efficiency of recovered struvite, FePO_4-sludge, digestate, and animal manure as compared to fossil reserve-based mineral triple superphosphate(TSP). First, product physicochemical characteristics and P fractions in the context of European fertilizer legislation were assessed. Next, a controlled greenhouse experiment was set up to evaluate plant reactions as well as changes of P availability in a sandy soil with high P status and a Rheinsand soil with low P status. Soil P fractions were determined in the extracts with water, ammonium lactate and CaCl_2, and in soil solution sampled with Rhizon soil moisture samplers. Based on all results, it is worth conducting long-term field trials to evaluate the P release effect of struvite and digestate as compared to animal manure and TSP on different soil types with varying P status. These products showed promise as sustainable substitutes for conventional P fertilizers and could contribute to a more efficient use of P in agriculture. A refined classification of P application standards/recommendations in terms of soil P status, soil texture, and fertilizer characteristics, next to the crop P demand, is recommended. Moreover, the additional use of Rhizon samplers for determination of direct available P, including dissolved organic P, is proposed for better understanding and categorization of different P fertilizers in environmental and fertilizer legislations. | Céline VANEECKHAUTE Joery JANDA Peter A.VANROLLEGHEM Filip M.G.TACK Erik MEERS | 2016 | Pedosphere2016，26，3： | 3 |
| 4 | Complement-Mediated Ischemia-Reperfusion Injury: Lessons Learned From Animal and Clinical Studies显示文摘 | Gwendolyn M. P. Diepenhorst Thomas M. van Gulik C Erik Hack | 2009 | Annals of Surgery2009，，： | 2 |
| 5 | Cardiovascular effects of marine omega-3 fatty acids显示文摘 | Palaniappan Saravanan Neil C Davidson Erik B Schmidt Philip C Calder | 2010 | The Lancet2010，，9740： | 2 |
| 6 | Synergistic activity of chitinases and β-1,3-glucanases enchance fungal resistance in transgenic tomato plants显示文摘 | Jongedijk Erik Henk Tigelear Jeroen S C Van Roekel | 1995 | Euphytica1995，85，13： | 1 |
| 7 | Bioactivity of TiN-coated titanium implants显示文摘 | Stefano P Lucio C C Erik V | 2004 | Acta Mater2004，52，5： | 1 |
| 8 | Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients显示文摘 | Erik S. Stroes Melchior C. Nierman Janneke J. Meulenberg Remco Franssen Jaap Twisk C Pieter Henny Mario M. Maas Aeilko H. Zwinderman Colin Ross Eleonora Aronica Katherine A. High Marcel M. Levi Michael R. Hayden John J. Kastelein Jan Albert Kuivenhoven | 2008 | Arteriosclerosis Thrombosis and Vascular Biology2008，，12： | 1 |
| 9 | Assessment of Laparoscopic suturing skills of urology residents:A pan-European study显示文摘 | Stephanie G C Kroeze Erik K | 2009 | EUR UROL2009，56，5： | 1 |
| 10 | Cardiac resynchronization therapy improves central sleep apnea and Cheyne-Stokes respiration in patients with chronic heart failure显示文摘 | Anil-Martin Sinha Erik C Skobel Ole-Alexander Breithardt Christine Norra Kai U Markus Christian Breuer Peter Hanrath Christoph Stellbrink | 2004 | Journal of the American College of Cardiology2004，，1： | 1 |
| 11 | Origins and mechanisms of miRNAs and siRNAs 显示文摘 | Richard W C Erik J S | 2009 | Cell2009，136，4： | 1 |
| 12 | Epithelial to mesenchymal transition and breast cancer显示文摘 | EVA T C ERIK W T JEAN P T | 2009 | Breast Cancer Research2009，11，6： | 1 |
| 13 | Assessing farmland protection policy in China显示文摘 | Erik Lichtenberg C D | 2008 | Land Use Policy2008，，25： | 1 |
| 14 | Acyclic nucleoside phosphonates:Past,present and future bridging chemistry to HIV,HBV,HCV,HPV,adeno2,herpes2,and poxvirus infections:The phosphonate bridge显示文摘 | Erik C | 2007 | Biochem Pharmacol2007，73，91： | 1 |
| 15 | Discovery and development of BVDU(brivudin) as a therapeutic for the treatment of herpes zoster显示文摘 | ERIK D C | 2004 | Biochem Pharmacol2004，68，12： | 1 |
| 16 | Microstructured hollow fibers for ultrafil- tration 显示文摘 | PINA Z C ERIK R CEES V R | 2010 | Journal of Membrane Sci- ence2010，347，12： | 1 |
| 17 | Hybrid model predictive control based on ireless sensor feedback:An experimental study显示文摘 | Alberto B Stefano D C Erik H | 2010 | International Journal of Robust and Nonlinear Control2010，20，2： | 1 |
| 18 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies显示文摘 | Erik von Elm Douglas G Altman Matthias Egger Stuart J Pocock Peter C G?tzsche Jan P Vandenbroucke | 2007 | The Lancet2007，，9596： | 1 |
| 19 | Cervical spine functional anatomy and the biomechanics of injury due to compressive loading显示文摘 | Erik E S Floyd R T Mike C | 2005 | J Athl Train2005，40，3： | 1 |
| 20 | Novel compounds in preclinieal/early clinical development for the treatment of HIV infections显示文摘 | ERIK DE C | 2000 | Rev Med Fifol2000，10，： | 1 |
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