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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Effects of percutaneous coronary interventions in silent ischemia after myocardial infarction: the SWISSI II randomized controlled trial显示文摘 | Erne P Schoenenberger AW Burckhardt D | 2007 | JAMA2007，297，： | 1 |
| 3 | Effects of antiischaemic drug therapy in silent myocardial ischaemia type Ⅰ:the swiss interventional study on silent ischaemia type Ⅰ (SWISSI I):a randomized,controlled pilot study显示文摘 | Erne P Schoenenberger AW Zuber M | 2007 | Eur Heart J2007，28，： | 1 |
| 4 | Correlation of platelet calcium antihypertensive therapy显示文摘 | Erne P Bolli P Burgisser E | 1984 | N Engl J Med1984，310，： | 1 |
| 5 | The road to bioabsorbable stents:Reaching clinical reality?显示文摘 | Erne P Schier M Resink T J | 2006 | Cardiovascular Int Radiology2006，29，1： | 1 |
| 6 | Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions:12 month results of the prospective,multicentre,first-in-man BIOSOLVE-I trial显示文摘 | Haude M Erbel R Erne P | 2013 | Lancet2013，381，9869： | 1 |
| 7 | Mean platelet volume and size distribution and their sensitivity to agonists in patients with coro nary artery disease and congestive heart failure显示文摘 | Erne P Wradie J Sanders K | 1988 | Thromb Hae most1988，59，2： | 1 |
| 8 | Platelets and hypertension显示文摘 | Erne P Webb DJ Dawes J | 1985 | J Cardiovasc Pharmaco1985，7，6： | 1 |
| 9 | Brachytherapy:potential therapy for refractory coronary spasm显示文摘 | Jamshidi P Juelke P | 2004 | J Am Coll Cardiol2004，44，7： | 1 |
| 10 | Alcohol-induced generation of lipid peroxidation products in humans显示文摘 | Ern rn a A Orla P Burke A | 1999 | J Clin Inv1999，104，： | 1 |
| 11 | Drug-eluting versus bare-metal stents in large coronary arteries 显示文摘 | Kaiser C Galatius S Erne P | 2010 | N Engl J Med2010，363，24： | 1 |
| 12 | Lower age at first myocardial in-farction in female compared to male smokers显示文摘 | Bahler C Gutzwiller F Erne P | | 0，，： | 1 |
| 13 | Impact of hy- pertension on the outcome of patients admitted with acute coronary syndrome显示文摘 | Erne P Radovanovic D Schoenenberger AW | 2015 | J Hypertens2015，33，4： | 1 |
| 14 | Percutaneous aspiration of inferior vena cava thrombus显示文摘 | Erne P Jamsshidi P | 2006 | J Invasive Cardiol2006，18，5： | 1 |
| 15 | Effects of percutaneous coronary interventions in silent ischemia after myocardial infarctio显示文摘 | Erne P Schoenenberger AW Burckhardt D | | 0，，： | 1 |
| 16 | The road to bioabsorbable stems: reaching clinical reality? 显示文摘 | Erne P Schier M Resink TJ | 2006 | Cardiovasc Intervent Radiol2006，29，1： | 1 |
| 17 | Myocardial tissue characterization in heart failure by real-time integrated backscatter显示文摘 | Zuber M Gerber K Erne P | 1999 | European Journal of Ultrasound1999，9，： | 1 |
| 18 | Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial显示文摘 | Haude M Erbel R Erne P | 2013 | Lancet2013，381，9869： | 1 |
| 19 | In-stent restenosis and thrombosis 41 months after drug-eluting stent implantation 显示文摘 | JAMSHIDI P TOGGWEILER S ERNE P | 2008 | International Journal of Cardiology2008，130，3： | 1 |
| 20 | Altered expression of the Ca^2+ -binding protein S100A1 in human cardiomyopathy显示文摘 | Remppis A Greten T Schafer B W Hunziker P Erne P Katus H A | 1996 | Biochim Biophys Acta1996，1313，： | 1 |
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