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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | FeNb在钢液中的溶化行为及在钢包精炼过程中提高Nb收得率的最佳工艺显示文摘阐述了标准铌铁(FeNb)的微观组织特性及其溶入钢液中的研究结果。在实验室的感应炉中进行了不同温度下的非连续试验,分析了固相FeNb与钢液凝固层界面的微观组织,并与原始FeNb粒子的微观组织进行了对比。这些试验研究结果可以阐释FeNb的溶解机制和它在不同炼钢温度下的融入动力学条件。标准FeNb在钢水中溶解的试验结果证实FeNb颗粒的溶解速率高于有关文献中报告的结果,它们认为FeNb粒子的熔化温度高(>1600℃),所以在其模型中假定FeNb的溶解仅是通过固相粒子的扩散实现。本项工作得到的试验证据为标准FeNb的溶解机理提供了一种新的说法:在1500~1510℃受其共晶区的熔化行为控制,在1530~1575℃温度范围内则由初始板条相的熔化行为所主导,也就是说,均低于1600℃左右的炼钢温度。根据这些研究结果和炼钢厂已有的生产经验,对于微合金化钢在二次精炼阶段加入FeNb推荐了最优的工艺。 | Edmundo Burgos Cruz Daniel Pallos Fridman Marcelo C Carboni Rogério Contato Guimares Marcos A Stuart Nogueira Ferdinando Luiz Cavallante 王厚昕 | 2010 | 世界钢铁2010，，6： | 2 |
| 3 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 4 | Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol显示文摘 | ABUCHOWSKI A VAN ES T PALCZUK N C | 1977 | J Biol Chem1977，252，11： | 1 |
| 5 | Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells显示文摘 | Guimarǎes E L Empsen C Geerts A | | 0，，03： | 1 |
| 6 | Levels of VEGF but not VEGF165b are Increased in the Vitreous of Patients With Retinal Vein Occlusion显示文摘 | Ehlken C Rennel ES Michels D Grundel B Pielen A Junker B etal | | 0，，： | 1 |
| 7 | Assessment of pretreatment laparotomy in patients with cervical carcinoma prior to radiotherapy显示文摘 | Podczaski ES Palombo C Manetta A | 1989 | Gynecol Oncol1989，33，1： | 1 |
| 8 | Shape and size of red blood ceils from the Pygoscelid penguins of Antarctica using atomic force microscopy显示文摘 | Bonatto C C Magalh(a)es B S Branco J O | | 0，，02： | 1 |
| 9 | Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs显示文摘 | Euler Moraes Penha Cássio Santana Meira Elisalva Teixeira Guimar?es Marcus Vinícius Pinheiro Mendon?a Faye Alice Gravely Cláudia Maria Bahia Pinheiro Taiana Maria Bahia Pinheiro Stella Maria Barrouin-Melo Ricardo Ribeiro-dos-Santos Milena Botelho Pereira | 2014 | Stem Cells International2014，，： | 1 |
| 10 | Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain显示文摘 | Garau C Miral es A Garcia-Sevil a J A | | 0，，02： | 1 |
| 11 | Variational elliptic problems which are nonquadratic at infinity显示文摘 | Costa D G Magalh(a)es C A | 1994 | Nonlinear Anal1994，23，11： | 1 |
| 12 | 黄粉虫替代蛋白质饲料对太平洋白虾(凡纳滨对虾)消化性能的影响显示文摘试验旨在评估黄粉虫粉(MM)作为凡纳滨对虾养殖中蛋白质来源的可行性。饲料分为正常饲料和试验饲粮,试验饲料中包含正常饲料85%和MM 15%,两种饲料中均含有氧化铬0.5%作为惰性标记,试验采用表观消化率系数(ADC)对两种饲料进行检测。为评估MM消化价值,对虾饲料中采用鱼粉替代MM,替代比例分别为0%、25%、50%、75%和100%,在清水中饲养6周后,对生长参数和整个虾体成分进行评估。干物质ADC为45.9%,能量ADC为66.5%,粗蛋白质ADC为76.1%,必须氨基酸ADC为72%~86%。MM中蛋氨酸为第一限制性氨基酸。饲料中添加MM后,各组间对虾的体增重、特定生长率、采食量、饲料转化率、存活率和蛋白质合成率均无显著变化(P>0.05),虾体蛋白质含量无显著差异(P>0.05)。而随着鱼粉替代比例上升,虾体脂含量从1.13%升至1.88%。结果表明,黄粉虫粉可作为凡纳滨对虾饲料中的替代蛋白质饲料,但添加时应注意补充蛋氨酸。 | Panini R L Freitas L E L Guimarǎes A M Rios C da Silva M F O Vieira F N Fracalossi D M Samuels R I | 2017 | 饲料博览2017，0，7： | 1 |
| 13 | Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol显示文摘 | Abuchowski A Van Es T Palczuk N C | 1977 | J Biol Chem1977，252，11： | 1 |
| 14 | Electro Chemical Characterization of Chromate Coatings on Galvanized Steel显示文摘 | Magalh es A A O Margarit I C P Mattos O R | 1999 | Electrochimica Acta1999，44，24： | 1 |
| 15 | Infection of CD127+ (interleukin-7 receptor + ) CD4+ ceils and overexpression of CTLA-4 are linked to loss of antigen- specific CD4 T cells during primary human immunodeficiency virus type 1 infection 显示文摘 | Zaunders JJ Ip S Munier ML Kaufmann DE Suzuki K Brereton C Sasson SC Seddiki N Koelsch K Landay A Grey P Finlayson R Kaldor J Rosenberg ES Walker BD Fazekas de St Groth B Cooper DA Kelleher AD | 2006 | J Virol2006，80，10： | 1 |
| 16 | Aheration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol 显示文摘 | Abuchowski A Van Es T Palczuk N C | 1977 | J Biol Chem1977，252，11： | 1 |
| 17 | The action of selected isothiocyanates on bacterial biofilm prevention and control显示文摘 | Borges A Simes L C Saavedra M J | 2014 | International Biodeterioration & Biodegradation2014，86，： | 1 |
| 18 | Re- duced expression of succinyl-Coenzyme a ligase can be compensated for by up-regulation of the 3,-Aminobutyrate shunt in illuminated tomato leaves 显示文摘 | Studart-Guimar es C Fait A Nunes-Nesi A | 2007 | Plant Physiolo- gy2007，145，3： | 1 |
| 19 | Multimethod study of the degree of humifieation of humic substances extracted from different tropical soil profiles in Brazil's Amazonian region显示文摘 | Rosa A H Sim? es M L de Oliveira L C | 2005 | Geoderma2005，127，： | 1 |
| 20 | Mechanical properties ofpoly(ε-caprolactone) and poly(lactic acid) blends 显示文摘 | Sim?es C L Viana J C Cunha A M | 2009 | Journal ofApplied Polymer Science2009，112，1： | 1 |
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