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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | Ultrasound in the Diagnosis of Ulnar NeuroPathy at the Cubital Tunnel 显示文摘 | Ethan R Wiesler George D Chloros Miehael S Cartwright | 2006 | The Journal of Hand Surgery2006，31，7： | 1 |
| 3 | Energy and material flow through the urban ecosystem 显示文摘 | Ethan H D Scott E | 2000 | Annual Review Energy Environment2000，25，： | 1 |
| 4 | The use of cervical fascia for hypopharyngeal reconstruction with laryngeal preservation显示文摘 | Ethanic D Milicic D | 2003 | Eur Arch Otorhinolarygol2003，260，4： | 1 |
| 5 | Porphyrin-based photosensitizers for use in photodynamic therapy 显示文摘 | ETHAN D S DAVID D | 1998 | Tetrahedron1998，，54： | 1 |
| 6 | Indocyanine green angiographic findings in nonproliferative diabetic retinopathy显示文摘 | Weinberger D Ichal K Ethan P | 1998 | Am J Ophthalmology1998，126，： | 1 |
| 7 | Can we measure snow depth with GPS receivers?显示文摘 | KRISTINE M L ETHAN D G VALERY U Z | 2009 | Geophysical Research Letters2009，36，17： | 1 |
| 8 | Promoting healthy vision in students:progress and challenges in policy,programs,and research显示文摘 | Ethan D Basch CE | 2008 | Journal of School Health2008，78，8： | 1 |
| 9 | 5]显示文摘 | Hennigar T LMacquarrie D C Supram olecular Isomerism in coordination polymers:conformational freedom of ligands in 2 - bis(4 - pyridyl)ethane)1 | 1997 | Angew Chem Int Ed1997，36，： | 1 |
| 10 | Ultrasound in the diagnosis of ulnar neuropathy at the cubital tunnel显示文摘 | Ethan R Wiesler George D Chloros Michal S Cartwright | 2006 | Journal of Hand Surgery2006，31，7： | 1 |
| 11 | The epidermal growth factor recep- tor and its ligind as therapeutic targets in human tumors 显示文摘 | VALCIE R JOHN M ETHAN D | 1996 | Cyto- kine & Growth factor reviews1996，7，： | 1 |
| 12 | Can we measure snow depth with GPS receivers?显示文摘 | KRISTINE M L ETHAN D G VALERY U Z | 2009 | Geophysical Research Letters2009，36，17： | 1 |
| 13 | Epithelial antibiotics induced at siles of inflammation显示文摘 | Ethan D Michael A | 1995 | Sciencs1995，267，： | 1 |
| 14 | Spatially correlated anomalous ^40Ar/^39Ar 'age' variations in biotites about a lithologic contact near Simplon Pass, Switzerland: A mechanistic explanation for excess Ar显示文摘 | Ethan F B Donald J D Paul R R | 2002 | Geochim et Cosmochim Acta2002，66，： | 1 |
| 15 | Ultrasound in the Diagnosis of Ulnar Neuropathy at the Cubital Tunnel显示文摘 | Ethan R Wiesler George D Chloros Michael S Cartwright | 2006 | The Journal of Hand Surgery2006，31，7： | 1 |
| 16 | Disruption of the clock components CLOCK and BMAL1 leads to hypoinsuli- naemia and diabetes显示文摘 | Marcheva B Ramsey KM Ethan D | 2010 | Nature2010，466，7306： | 1 |
| 17 | Do Not Resuscitate status as an independent risk factor for patients undergoing surgery for hip fracture显示文摘AIM To determine morbidity and mortality in this specific patient group and also to assess for any independent associations between Do Not Resuscitate(DNR) status and increased post-operative morbidity and mortality.METHODS We conducted a propensity score matched retrospective analysis using de-identified data from the American College of Surgeons' National Surgical Quality Improvement Project(ACS NSQIP) for all patients undergoing hip fracture surgery over a 7 year period in hospitals across the United States enrolled in ACS NSQIP with and without Do Not Resuscitate Status. We measured patient demographics including DNR status, co-morbidities, frailty and functional baseline, surgical and anaestheticprocedure data, post-operative morbidity/complications, length of stay, discharge destination and mortality.RESULTS Of 9218 patients meeting the inclusion criteria, 13.6% had a DNR status, 86.4% did not. Mortality was higher in the DNR status compared to the non-DNR group, at 15.3% vs 8.1% and propensity score matched multivariable analysis demonstrated that DNR status was independently associated with mortality(OR = 2.04, 95%CI: 1.46-2.86, P < 0.001). Additionally, analysis of the propensity score matched cohort demonstrated that DNR status was associated with a significant, but very small increased likelihood of post-operative complications(0.53 vs 0.43 complications per episode; OR = 1.21; 95%CI: 1.04-1.41, P = 0.004). Cardiopulmonary resuscitation and unplanned reintubation were significantly less likely in patients with DNR status.CONCLUSION Whilst DNR status patients had higher rates of postoperative complications and mortality, DNR status itself was not otherwise associated with increased morbidity. DNR status appears to increase 30-d mortality via ceilings of care in keeping with a DNR status, including withholding reintubation and cardiopulmonary resuscitation. | Ethan Y Brovman Andrew J Pisansky Anair Beverly Angela M Bader Richard D Urman | 2017 | World Journal of Orthopedics2017，8，12： | 1 |
| 18 | Coadministration of telaprevir and transcatheter arterial chemoembolization in hepatitis C virus-associated hepatocellular carcinoma显示文摘The use of directacting antiviral agents (e.g. , telaprevir, boceprevir) has improved response rates in patients with hepatitis C virus (HCV) genotype 1 infections. Substantial number of drug-drug interactions are anticipated with the use of telaprevir, a cytochrome P450 3A and P-glycoprotein substrate and inhibitor. Herein we describe a patient with HCV-associated hepatocellular carcinoma treated simultaneously with a telaprevir-containing regimen and localized chemo-therapy (transcatheter arterial chemoembolization) with doxorubicin. No clinically relevant interactions or adverse events developed while on antiviral therapy. | Harrys A Torres Parag Mahale Ethan D Miller Thein H Oo Catherine Frenette Ahmed O Kaseb | 2013 | World Journal of Hepatology2013，5，6： | 1 |
| 19 | The use of cervical fascia for hypopha?ryngeal reconstruction with laryngeal preservation显示文摘 | Ethanic D Milicic D | 2003 | Eur Arch Otorhinolaryngo2003，260，4： | 1 |
| 20 | A Real- Time Multi- Agent System Architecture for E-Commerce Applications 显示文摘 | Lisa C D Victor F W Lekshmi N Ethan H Oleg U | 2000 | Computer Standards & Interfaces2000，，22： | 1 |
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