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| 1 | 植物在修复、固定和重建水生、陆生生态系统中的应用显示文摘植物能够吸收或降解污染物来修复受污染的土壤和水体[1-2],还能固定土壤、泥沙防止侵蚀和污染物从固体介质中释放[3]。众多无机和有机污染物都能被对其有耐性且生物量大的植物有效降解。例如,凤眼莲能吸收和净化来自金矿采掘废水的氰化物,这类废水含各种氰化物以及重金属元素的浓度达到导致生物体产生毒性效应的水平。检测表明氰化物对凤眼莲的半数致死剂量(LC50)为13 mg/L,将经过高浓度氰化物废水驯化后的凤眼莲放在野外小型湿地进行试验,结果显示这类植物对氰化物的降解效率更高。放射性同位素试验发现氰化物分子中的C和N原子经过植物代谢合成天冬酰胺,从而将有毒性的氰化物转化为无毒的产物[4]。尾矿场也可以用植物来修复,一方面植物可以过滤污染物浓度很高的渗滤液,另一方面栽种植物可以固定边坡减少侵蚀。将高覆盖度植被的概念应用在一个尾矿场上,通过种植北美黄杉使其全年都维持较高的蒸腾效率来减少渗滤液。而边坡的固定首先需要在坡面安置固定、菱形的新鲜柳条编织成的笼状网格,其后覆上土壤并喷播能在生长期对固定土壤发挥作用的草本、灌木以及树木种子。这项技术同样适用于河岸侵蚀防护。 | Andreas SCHAEFFER 陈忠礼 Mathias EBEL Michael EVANGELOU Henner HOLLERT Martina RO-NICKOLL Burkhard SCHMIDT 袁野 Gottfried LENNARTZ | 2012 | 重庆师范大学学报(自然科学版)2012，29，3： | 4 |
| 2 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 3 | E2F transcription factors and digestive system malignancies:How much do we know?显示文摘The E2F proteins comprise a family of 8 members that function as transcription factors.They are key targets of the retinoblastoma protein(RB)and were initially divided into groups of activators and repressors.Accumulating data suggest that there is no specific role for each individual E2F member.Instead,each E2F can exert a variety of cellular effects,some of which represent opposing ones.For instance,specific E2Fs can activate transcription and repression,promote or hamper cell proliferation,augment or inhibit apoptosis,all being dependent on the cellular context.This complexity reflects the importance that these transcription factors have on a cell’s fate.Thus,delineating the specific role for each E2F member in specific malignancies,although not easy,is a challenging and continuously pursued task,especially in view of potential E2F targeted therapies.Therefore,several reviews are continuously trying to evaluate available data on E2F status in various malignancies.Such reviews have attempted to reach a consensus,often in the simplistic form of oncogenes or tumor suppressor genes for the E2Fs.However they frequently miss spatial and temporal alterations of these factors during tumor development,which should also be considered in conjunction with the status of the regulatory networks that these factors participate in.In the current‘‘Letter to the Editor’’,we comment on the flaws,misinterpretations and omissions in one such review article published recently in the World Journal of Gastroenterology regarding the role of E2Fs in digestive system malignancies. | Konstantinos Evangelou Sophia Havaki Athanassios Kotsinas | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 4 | Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics显示文摘 | Sarah K McGill Evangelos Evangelou John P A Ioannidis Roy M Soetikno Tonya Kaltenbach | 2013 | Gut2013，，12： | 2 |
| 5 | A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes显示文摘Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural deterioration.Genetic pleiotropy occurs when a single genetic element is associated with more than one phenotype.We aimed to identify pleiotropic loci associated with bone mineral density(BMD)and nonbone phenotypes in genome-wide association studies.In the discovery stage,the NHGRI-EBI Catalog was searched for genome-wide significant associations(P value<5 x 108),excluding bone-related phenotypes.SNiPA was used to identify proxies of the significantly associated single nucleotide polymorphisms(SNPs)(r2=1).We then assessed putative genetic associations of this set of SNPs with femoral neck(FN)and lumbar spine(LS)BMD data from the GEFOS Consortium.Pleiotropic variants were claimed at a false discovery rate<1.4x 103 for FN-BMD and<1.5 x 10-3 for LS-BMD.Replication of these genetic markers was performed among more than 400000 UK Biobank participants of European ancestry with available genetic and heel bone ultrasound data.In the discovery stage,72 BMD-related pleiotropic SNPs were identified,and 12 SNPs located in 11 loci on 8 chromosomes were replicated in the UK Biobank.These SNPs were associated,in addition to BMD,with 14 different phenotypes.Most pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U C 1 gene),which was associated with magnesium levels and gastroenterological cancer.In conclusion,12 BMD-related genome-wide significant SNPs showed pleiotropy with nonbone phenotypes.Pleiotropic associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits. | Maria A.Christou Georgios Ntritsos Georgios Markozannes Fotis Koskeridis Spyros N.Nikas David Karasik Douglas P.Kiel Evangelos Evangelou Evangelia E.Ntzani | 2020 | Bone Research2020，8，3： | 2 |
| 6 | Biochar and biochar-compost as soil amendments to a vineyard soil: Influences on plant growth, nutrient uptake, plant health and grape quality显示文摘 | Hans-Peter Schmidt Claudia Kammann Claudio Niggli Michael W.H. Evangelou Kathleen A. Mackie Samuel Abiven | 2014 | Agriculture, Ecosystems and Environment2014，，： | 2 |
| 7 | Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor 显示文摘 | Heisler LE Evangelou A Lew AM | 1997 | Mol Cell Endocrinol1997，126，1： | 1 |
| 8 | The 3' UTR IGF2R- A2/B2 variant is associated with increased tumor growth and advanced stages in non-small cell lung cancer 显示文摘 | Kotsinas A Evangelou K Sideridou M | 2008 | Cancer Lett2008，259，2： | 1 |
| 9 | E2F1 overexpression correlates with decreased prolifer- ation and better prognosis in adenocarcinomas of Bar- rett oesophagus显示文摘 | Evangelou K Kotsinas A Mariolis-Sapsakos T | 2008 | J Clin Pathol2008，61，： | 1 |
| 10 | Electrical and Structural Characteristics of Yttrium Oxide Films Deposited by RF Magnetren Sputtering on n-Si显示文摘 | Evangelou E K Wiemer C Fanciulli M | 2003 | Applied Physics2003，94，1： | 1 |
| 11 | Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects显示文摘 | Mallory Owen Michael Shevell Mary Donofrio Annette Majnemer Robert McCarter Gilbert Vezina Marine Bouyssi-Kobar Iordanis Evangelou Dena Freeman Neil Weisenfeld Catherine Limperopoulos | 2013 | The Journal of Pediatrics2013，，： | 1 |
| 12 | Relationships between cadmium, zinc, Cd-peptide, and organic acid in tobacco suspension cells 显示文摘 | KROTZ R M EVANGELOU R M WAGNER G J | 1989 | Plant physiology1989，91，2： | 1 |
| 13 | The influence of humic acids on the phytoextraction of cadmium from soil 显示文摘 | Michael W H EVANGELOU HATICE DAGHAN | 2004 | Chemosphere2004，，57： | 1 |
| 14 | Regular and Irregular Progressive Edge-Growth Tanner Graphs 显示文摘 | HU Xiao-yu Evangeles Eleftheriou Dieter M Arnold | 2005 | IEEE Transactions on Information Theory2005，51，1： | 1 |
| 15 | A review of the technical and clinical aspects of endoscopy显示文摘 | Kay CL Evangelou HA | 1996 | Endoscopy1996，29，： | 1 |
| 16 | Cdc6 expression represses E cadherin transcription and activates adjacent replication origins 显示文摘 | Sideridou M Zakopoulou R Evangelou K | 2011 | J Cell Biol2011，195，7： | 1 |
| 17 | Aluminum and iron equilibria in soil solutions and sur face waters of acid mine watersheds显示文摘 | KARATHANASIS A D EVANGELOU V P THOMPSON Y L | 1988 | Journal of Environ- mental Quality1988，17，4： | 1 |
| 18 | Cyanide phytoremediation by water hyacinth ( Eichhornia crassipes ) 显示文摘 | Ebel M Evangelou M Schiffer A | 2006 | Chemosphere2006，66，： | 1 |
| 19 | Down-regulation of transforming growth factor beta receptors by androgen in ovarian cancer cells显示文摘 | Evangelou A Jindal SK Brown TJ | 2000 | Cancer Res2000，60，4： | 1 |
| 20 | Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma 显示文摘 | Evangelou G Farrar MD Cotterell L | 2012 | Br J Dermatol2012，166，5： | 1 |
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