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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Division of Giardia osolates from humans into two genetically dis- tinct assemblages by electrophoretie analysis of en- zymes encoded at 27 loci and comparison with Giardia muris显示文摘 | Mayrhofer G Andrews R H Ey P L | 1995 | Parasitology1995，111，1： | 1 |
| 3 | Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose显示文摘 | Ey P L Prowse S J Jenkin C R | 1998 | Immunochemistry1998，15，： | 1 |
| 4 | Obtaining sub-gridscale information from coarse-resolution general circulation model output 显示文摘 | Wig|ey T M L Jones P D Briffa K R | 1990 | Journal of Geophysical Research1990，95，： | 1 |
| 5 | Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose显示文摘 | Ey P L Prowse S J Jenkin C R | 1978 | Immunocheraistry1978，15，： | 1 |
| 6 | IntCall 3 and Marine 13 Radicarxm Age Calibration Curves 0-50,000 Years cal BP显示文摘 | REIMER P J BARD E BAYLISS A BECK J W BLACKWELL P G RAMSEY C B BUCK C E CHENG H EDWARDS R L FRIEDRICH M GROOTES P M GUILDERSON T P HAFLIDASON H HAJDAS 1 HATTt C HEATON T J HOFFMANN 1) L HOGG A G HUGHEN K A KAISER K F KROMER B MANNING S M NIU M REIMER R W RICHARDS D A SCOTF EM SOUTHON J R STAFF R A TURN EY CSM VAN I)ER Plicht | 2013 | Radiocarbon2013，55，： | 1 |
| 7 | Isolation of pure IgG1,IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose显示文摘 | EY P L PROWSE S J JENKIN C R | 1978 | Immunochemistry1978，15，7： | 1 |
| 8 | Isolation of pure IgG1,IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose显示文摘 | Ey P L Prowse S J Jenkin C R | 1978 | Immunochemistry1978，15，： | 1 |
| 9 | Isolation of pure IgGl,IgG2a and IgG2b immunoglobulins from mouse serum using protein A sepharose显示文摘 | EY P L PROWSE S J JENKIN C R | 1978 | Immunochemistry1978，15，7： | 1 |
| 10 | Spatial and temporal variability of soil respiration in agricultural fields 显示文摘 | ROCHETYE P DESJARDINS R L PATI'EY E | 1991 | Canadian Journal of Soil Science1991，71，2： | 1 |
| 11 | Isolation of pure IgGl, IgG2a and IgG2b immunoglobulins from mouse serum using protein A sepharose 显示文摘 | Ey P L Prowse S J J enkin C R | 1998 | Immunochemistry1998，15，： | 1 |
| 12 | Neural stern cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury 显示文摘 | LU P JONES L L SNYDER EY | 2003 | Exp Neurol2003，181，2： | 1 |
| 13 | Building knowledge for substation-based decision support using rough sets显示文摘 | HOR C L CROSSL EY P A WATSON S J | | 0，，03： | 1 |
| 14 | Dietary effect son breast cancer risk in Singapore 显示文摘 | H P LEE L Gourl EY S W Duefy | 1991 | Lancet1991，337，： | 1 |
| 15 | Multi-aspect analysis of ureteral access sheath usage in retrograde intrarenal surgery: A RIRSearch group study显示文摘Objective:To evaluate the effect of ureteral access sheath(UAS)use and calibration change on stone-free rate and complications of retrograde intrarenal surgery(RIRS).Methods:Data from 568 patients undergoing RIRS for kidney or upper ureteral stones were retrospectively included.Firstly,patients were compared after 1:1 propensity score matching,according to UAS usage during RIRS(UAS used[+]87 and UAS non-used[−]87 patients).Then all UAS+patients(n=481)were subdivided according to UAS calibration:9.5-11.5 Fr,10-12 Fr,11-13 Fr,and 13-15 Fr.Primary outcomes of the study were the success and complications of RIRS.Results:Stone-free rate of UAS+patients(86.2%)was significantly higher than UAS−patients(70.1%)after propensity score matching(p=0.01).Stone-free rate increased with higher caliber UAS(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;p<0.001).Postoperative complications of UAS+patients(11.5%)were significantly lower than UAS−patients(27.6%)(p=0.01).Complications(8.7%)with 9.5-11.5 Fr UAS was lower than thicker UAS(17.2%)but was not statistically significant(p=0.09).UAS usage was an independent factor predicting stone-free status or peri-and post-operative complications(odds ratio[OR]3.654,95%confidence interval[CI]1.314-10.162;OR 4.443,95%CI 1.350-14.552;OR 4.107,95%CI 1.366-12.344,respectively).Conclusion:Use of UAS in RIRS may increase stone-free rates,which also increase with higher caliber UAS.UAS usage may reduce complications;however,complications seemingly increase with higher UAS calibration. | OktayÖzman HacıM.Akgül Cem Başataç ÖnderÇınar Eyüp B.Sancak Cenk M.Yazıcı BülentÖnal Haluk Akpınar on behalf of the RIRSearch Study Group | 2024 | Asian Journal of Urology2024，11，1： | 0 |
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