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40篇 您的检索式：作者名="Eakin L"

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	题名	作者	年代	出处	被引量
1	Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer显示文摘Despite recent improvements to current therapies and the emergence of novel agents to manage advanced non-small cell lung cancer(NSCLC),the patients′overall survival remains poor.Re-challenging with first-line chemotherapy upon relapse is common in the management of small cell lung cancer but is not well reported for advanced NSCLC.NSCLC relapse has been attributed to acquired drug resistance,but the repopulation of sensitive clones may also play a role,in which case re-challenge may be appropriate.Here,we report the results of re-challenge with gemcitabine plus carboplatin in 22 patients from a single institution who had previously received gemcitabine plus platinum in the first-line setting and had either partial response or a progression-free interval of longer than 6 months.In this retrospective study,the charts of patients who underwent second-line chemotherapy for NSCLC in our cancer center between January 2005 and April 2010 were reviewed.All the patients who received a combination of gemcitabine and carboplatin for re-challenge were included in the study.These patients were offered second-line treatment on confirmation of clear radiological disease progression.The overall response rate was 15%and disease control rate was 75%.The median survival time was 10.4 months,with 46%of patients alive at 1 year.These results suggest that re-challenge chemotherapy should be considered in selected patients with radiological partial response or a progression-free survival of longer than 6 months to the initial therapy.	Khurum Khan Gerard G Hanna Lynn Campbell Paula Scullin Adnan Hussain Ruth L Eakin Jonathan McAleese	2013	Chinese Journal of Cancer2013，32，10：	3
2	Assessing the vulnerability of social-environ- mental systems显示文摘	Eakin H Luers A L	2006	Annual Review of Environment and Resources2006，31，1：	1
3	Phosphorus budget and management strategies for an urban Wisconsin lake 显示文摘	James William F Barko John W Eakin Harry L Sorge Patrick W	2002	Lake&ReservoirManagement2002，18，2：	1
4	The Viscosity of Natural Aases显示文摘	Lee A L Gonzalez M H Eakin B E	1966	Journal of Petroleum Technology1966，18，8：	1
5	The viscosity of natural gases 显示文摘	LEE A L GONZALEZ M H EAKIN B E	1966	JPT1966，，：	1
6	Internal Phosphorus Loading in Lake Pepin,Upper Mississippi River显示文摘	James W F Barko J W Eakin H L	1995	Journal of Freshwater Ecology1995，10，：	1
7	The marital and family func?tioning of adults with ADHO and their spouses显示文摘	Eakin L Minde K Hechtman L	2004	J Atten Disord2004，8，1：	1
8	Assessing the vulnerability of social-environment systems显示文摘	Eakin H Luers A L		0，，01：	1
9	Assessing the vulnerability of social-environ- mental systems 显示文摘	Eakin H Luers A L	2006	Annual Review of Environ-ment and Re- sanrces2006，31，：	1
10	The viscosity of natural gases显示文摘	Lee A L Gonzalez M H Eakin B E	1966	JPT1966，18，8：	1
11	Assessing the vulnerability of social-environmental systems显示文摘	Eakin H Luers A L	2006	Annual Review of Environmeand Resources2006，，31：	1
12	Assessing the vulnerability of social-environmental systems显示文摘	EAKIN H LUERS A L	2006	Annual Review of Environ-meat and Resources2006，31，：	1
13	Assessing the vulnerability of social-environmental systems显示文摘	Eakin H Luers A L		0，，：	1
14	The viscosity of natural gases显示文摘	Lee A L Gonzalez M H Eakin B E	1966	Journal of Petroleum Technology1966，18，8：	1
15	The viscosity of natural gases 显示文摘	Lee A L Gonzalez M H Eakin B E et ol	1966	JPT1966，18，8：	1
16	Supportive care needs of people with brain tumours and their carers 显示文摘	Janda M Eakin EG Bailey L	2006	Support Care Cancer2006，14，1：	1
17	Phosphorus budget and management strategies for an urban Wisconsin lake显示文摘	JAMES W F BARKO J W EAKIN H L	2002	Lake & Reservoir Management2002，18，2：	1
18	Quality of life an- dassoeiated ctmracterisfics in a large national sample of adult swith diabetes显示文摘	Glasgow RE Ruggiero L Eakin EG	1997	Diabetes Care1997，20，4：	1
19	Insights into the composition of household vulnerability from multicriteria decision analysis显示文摘	EAKIN H BOJORQUEZz-TAPIA L A	2008	Global Environmental Change2008，18，1：	1
20	Assessing the vulnerability of social- environment systems 显示文摘	EAKIN H LUERS A L	2006	Annual review of environment and resources2006，31，：	1

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