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| 1 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 2 | Verlebroplasty: A new treatment strategy for osteoporotic compression fractures显示文摘 | Eck JC Hodges SD Humphreys SC | 2002 | Am J Orthop2002，31，： | 1 |
| 3 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures:a meta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | | 0，，： | 1 |
| 4 | Biomechanical study on the effect of cervical spine fusion on adjacent-level intradiscal pressure and segmental motion显示文摘 | Eck JC Humphreys SC Lim TH | 2002 | Spine(Phila Pa 1976)2002，27，22： | 1 |
| 5 | Comparison of vertebro-plasty and balloon kyphoplasty for treatment of vertebral compressionfractures:a meta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | 2008 | Spine2008，8，： | 1 |
| 6 | Comparison of vvrtebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures: a recta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | 2008 | Spine J2008，8，3： | 1 |
| 7 | Comparison of verte-bro- plasty and balloon kyphoplasty for treatment of vertebral eompression- fractures:a meta-analysis of the literature 显示文摘 | Eck JC Nachtigall D Humphreys SC | 2008 | Spine J2008，，8： | 1 |
| 8 | Comparison of vertebroplasty and balloon kyphoplasty {or treatment of vertebral compression fractures:a meta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | 2008 | Spine J2008，8，3： | 1 |
| 9 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures:a meta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys C | | 0，，03： | 1 |
| 10 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures:a meta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | | 0，，03： | 1 |
| 11 | Biomechanical study on the effect of cervical spine fusion on adjacent-level intradiscal pressure and segmental motion 显示文摘 | Eck JC Humphreys SC Lim TH | 2002 | Spine2002，27，22： | 1 |
| 12 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures:a meta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | | 0，，3： | 1 |
| 13 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures:a metaanalysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | | 0，，03： | 1 |
| 14 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures: a meta-analysis of the literature 显示文摘 | Eck JC Nachtigall D Humphreys SC | 2008 | Spine2008，8，3： | 1 |
| 15 | Urgent surgical decompression compared to methylprednisolone for the treatment of acute spinal cord injury显示文摘 | Rabinowitz RS Eck JC Harper CM Jr | 2008 | Spine2008，33，21： | 1 |
| 16 | Biomechanical study on the effect of cervical spine fusion on adjacent-level intradiscal pressure and segmental motion显示文摘 | Eck JC Humphreys SC Lim TH | | 0，，1976： | 1 |
| 17 | Biomechanical study on the effect of cervical spine fusion on adjacentlevel in- tradiscal pressure and segmental motion显示文摘 | Eck JC Humphreys SC Lim TH | 2002 | Spine2002，27，22： | 1 |
| 18 | Adjacent-segment degeneration after lumbar fusion= A review of clinical, biomechanical, and radiologic studies 显示文摘 | Eck JC Humphreys SC Hodges SD | 1999 | Am J Orthod Dentofac1999，28，6： | 1 |
| 19 | Intraoperative loosening of Bagby and Kuslich cages during anterior lumbar interbody fusion显示文摘 | Hodges SD Humphreys SC Eck JC | 2000 | J Spinal Disord2000，13，6： | 1 |
| 20 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fracures:a meta-analysis of the literature显示文摘 | Eck JC Nachtigall D Humphreys SC | 2008 | Spine2008，8，3： | 1 |
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