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	题名	作者	年代	出处	被引量
1	2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk显示文摘	Eckel R H Jakicic J M Ard J D	2013	J Am Coil Cardiol2013，12，2：	1
2	The adipocyte-myocyte axis in insulin resistance显示文摘	Sell H Dietze-Schroeder D Eckel J	2006	Trends Endoerinol Metab2006，17，10：	1
3	Development of lipoprotein lipase in cultured 3T3-L1 cells显示文摘	ECKEL R H FUJIMOTO W Y BRUNZELL J D	1997	Biochem Biophys Res Commun1997，78，：	1
4	The adipocyte-myocyteaxis in insulin resistance显示文摘	Sell H Dietze-Schroeder D Eckel J	2006	Trends Endocrinol Metab2006，17，10：	1
5	Epitopes of the NS3 protein of hepatitis C virus:Recognition in HLA-DR4 transgenic mice显示文摘	Eckels D D	2002	Immunol Cell Bi-ol2002，80，1：	1
6	Postoperative prophylactic antibiotic treatment in third molar surgery-a necessity?显示文摘	Poeschl P W Eckel D Poeschl E	2004	J Oral Maxillofac Surg2004，62，1：	1
7	The Role of Shared Governance in In- stitutional Hard Decisions: Enabler or antagonist? 显示文摘	ECKEL P D	2000	The Review of Higher Education2000，24，1：	1
8	Oxidation kinetics and stress effects for the oxidation of continuous carbon fibers within a inicrocracked C/SiC ceramic matrix composite 显示文摘	Halbig M C Mcguffin-Cawley J D Eckel A J	2008	Journal of the American Ceramic Society2008，91，2：	1
9	Overweight in children and adolescents:pathophysiology,consequences,prevention,and treatment显示文摘	DANIELS S R ARNETT D K ECKEL R H	2005	Circulation2005，111，15：	1
10	Selective signal transduction thro ugh the CD3 o r CD2 complexis required for class Ⅱ MHC expression by human T cells显示文摘	Oshima S Eckels D D	1990	J Immunol1990，145，：	1
11	Postoperative prophylactic an- tibiotic treatment in third molar surgery - a necessity显示文摘	Poesehl PW Eckel D Poeschl E	2004	Journal o Oral and MaxiUofacial Surgery2004，62，1：	1
12	Meeting Today's Governance Challenges显示文摘	Kezar A Eckel P D	2004	The Journal of Higher Education2004，75，4：	1
13	Effect of inundation upon condensation heat transfer performance of R- 134a ( Ⅱ ) : results 显示文摘	RANDALL D L ECKELS S J	2005	International Journal of HVAC&R Research2005，11，4：	1
14	A patient outreach program between visits improves diabetes care:a pilot study显示文摘	Denberg T D Myers B A Eckel R H	2009	Int J Qual Health Care2009，2，21：	1
15	Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity显示文摘AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV.METHODS:Nucleotides 3519-3935 of the non-structural 3(NS3) region were amplified by using reverse transcription polymerase chain reaction(PCR).PCR products of the HCV NS3 regions were integrated into a PCR T7TOPO TA vector and then sequenced in both directions using an automated DNA sequencer.Relative major histocompatibility complex binding levels of wild-type and variant peptides were performed by fluorescence polarization-based peptide competition assays.Peptides with wild type and variant sequences of NS3 were synthesized locally using F-moc chemistry and purified by high-performance liquid chromatography.Specific cytotoxic T lymphocytes(CTLs) clones toward HCV NS3 wild-type peptides were generated through limiting dilution cloning.The CTL clones specifically recognizing HCV NS3 wild-type peptides were tested by tetramer staining and flow cytometry.Cytolytic activity of CTL clones was measured using target cells labeled with the fluorescence enhancing ligand,DELFIA EuTDA.RESULTS:The pattern of natural variants within three human leukocyte antigen(HLA)-A2-restricted NS3 epitopes has been examined in one patient with chronic HCV infection at 12,28 and 63 mo post-infection.Results obtained may provide convincing evidence of immune selection pressure for all epitopes investigated.Statistical analysis of the extensive sequence variation found within these NS3 epitopes favors a Darwinian selection model of variant viruses.Mutations within the epitopes coincided with the decline of CTL responses,and peptide-binding studies suggested a signif icant impact of the mutation on T cell recognition rather than peptide presentation by HLA molecules.While most variants were either not recognized or elicited low responses,such could antagonize CTL responses to target cells pulsed with wild-type peptides.CONCLUSION:Cross-recognition of CTL epitopes from wild-type and naturally-occurring HCV variants may lead to impaired immune responses and ultimately contribute to viral persistence.	Shuping Wang Rico Buchli Jennifer Schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels	2010	World Journal of Gastroenterology2010，16，16：	1
16	2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk:a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines 显示文摘	ECKEL R H JAKICIC J M ARD J D	2014	Cir- culation2014，129，：	1
17	Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat 显示文摘	Smith S J Cases S Jensen D R Chen H C Snade E Tow B Snaan D A Raber J Eckel R H Farese R V	2000	Nature Genetics2000，25，1：	1
18	Leptin and tumor necrosis factor-alpha induce the tyrosine phosphorylation ofsignal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo显示文摘	Rizk NM Stammsen D Preibisch G Eckel J	2001	Endocrinology2001，142，：	1
19	Postoperative prophylactic antibiotic treatment in third molar surgery-a necessity? 显示文摘	Poeschl PW Eckel D Poeschl E	2004	J Oral Maxillofac Surg2004，62，1：	1
20	Prevention Con- ference VII: obesity, a worldwide epidemic related to heart disease and stroke: executive sununm显示文摘	Eckel R H York D A Rossner S	2004	Circula- tion2004，110，18：	1

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