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| 1 | A randomized trial comparing the Tennant Biomodulator to transcutaneous electrical nerve stimulation and traditional Chinese acupuncture for the treatment of chronic pain in military service members显示文摘Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service members.The Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label trial.Methods:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual care.Recruitment was conducted between May 2010 to September 2013.Outcome measures were collected at intake,before and after each treatment session,and at a 1-month follow-up.Intent-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic effects.Outcomes measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and depression.Results:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,P<0.0001]and an 11%reduction in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,P<0.0001]from baseline to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month follow-up.Symptoms of PTSD and depression did not change significantly as a function of time or group.Conclusions:Findings build on previous work suggesting that traditional Chinese acupuncture and TENS can reduce pain and its functional sequelae without risks associated with pharmacological pain management.The Tennant Biomodulator used on its most basic setting performs as well as these other interventions.Based on the present findings,large,randomized controlled trials on the Tennant Biomodulator are indicated.Future work should test this device using its full range of settings for pain-related psychological health.Trial registration:Clincialtrials.gov(NCT01752010);registered December 14,2012. | Kimberly S.Peacock Erika Stoerkel Salvatore Libretto Weimin Zhang Alice Inman Michael Schlicher John D.Cowsar Jr David Eddie Joan Walter | 2020 | Military Medical Research2020，7，2： | 3 |
| 2 | A vitamin D receptor-alkylating derivative of 1alpha,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth显示文摘 | Lambert JR Eddy VJ Young CD | 2010 | Cancer Prev Res(Phila)2010，3，12： | 1 |
| 3 | The staged celiotomy for trauma issues in unpacking and reconstruction 显示文摘 | Morris JA Jr Eddy VA Blinman TA | 1993 | Ann Surg1993，217，5： | 1 |
| 4 | The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues显示文摘 | Raport CJ Schweickart VL Eddy RL Jr | 1995 | Gene1995，163，2： | 1 |
| 5 | Localization of a human mucin gene(MUC8) and the cloning of the cDNA corresponding to the carboxy terminus 显示文摘 | Shankar V Pichan P Eddy JR | 1997 | Am J Respir Cell Mol Biol1997，16，3： | 1 |
| 6 | MOCVD growth of thick AlN and AlGaN superlattice structures on Si substrates显示文摘 | Mastro M A Eddy Jr C R Gaskill D K | 2006 | J Cryst Growth2006，287，2： | 1 |
| 7 | Free radica-producing enzyme,Xanthien oxidase, is undetectable in human heart显示文摘 | Eddy LJ Stewart JR Jones HP etal | 1987 | Am J Physiol1987，253，： | 1 |
| 8 | Free radical inducing enzyme xanthine oxides is undetectable in human heart显示文摘 | Eddy LJ Stewart JR Johs HP | 1987 | Am J Phsiol1987，253，： | 1 |
| 9 | The staged celiotomy for trauma:issues in unpacking and reconstruction 显示文摘 | Morrisja JR Eddy VA Blinma NT | 1993 | Ann Surg1993，217，5： | 1 |
| 10 | Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus显示文摘 | Shankar V Pichan P Eddy RL Jr | | 0，，03： | 1 |
| 11 | Chromosomal localization of a human mucin gene(MUC 8) and cloning of the eDNA corresponding to the carboxy termious显示文摘 | ShankarV PichanP Eddy RL Jr | 1997 | Am J Pespir Cell Mol Biol1997，16，： | 1 |
| 12 | The staged celiotomy for trauma:issues in unpacking and reconstruction显示文摘 | Morris JA Jr Eddy VA Blinman T | 1993 | Ann Surg1993，217，5： | 1 |
| 13 | Analysis of complications and long-term outcome of trauma patients with needle catheter jejunostomy显示文摘 | Eddy VA Snell JE Morris JA Jr | 1996 | Am Surg1996，62，： | 1 |
| 14 | Role of conformational and positional adaptability in structure-based design of TMC125 and related NNRTIs that are highly potent and effective against wild-type and drug-resistant HIV-1 variants 显示文摘 | Kalyan D Jr Clark AD Eddy A | 2004 | J Med Chem2004，47，10： | 1 |
| 15 | Radiofrequency ablation for the treat- ment of radiation proctitis : a case report and review of literature 显示文摘 | Eddi R Depasquale JR | 2013 | Therap Adv Gastroenterol2013，6，1： | 1 |
| 16 | A vitamin D receptor - al-kylating derivative of 1,25 - dihydroxy vitamin D3 inhibits growth ofhuman kidney cancer cells and suppresses tumor growth显示文摘 | Lambert JR Eddy VJ Young CD | 2010 | Canc-er Prev Res (Phila)2010，3，12： | 1 |
| 17 | Isolation of viable mouse primordial germ cells by antibody-directed flow sorting显示文摘 | McCarrey JR Hsu KC Eddy EM | 1987 | J Exp Zool1987，242，： | 1 |
| 18 | The staged celiotomy for trauma:issues in unpacking and reconstruction显示文摘 | Morris JA Jr Eddy VA Blinman T | 1993 | Ann Surg1993，217，5： | 1 |
| 19 | The staged celiotomy for trauma:issues in unpacking and reconstruction 显示文摘 | Morris JA Jr Eddy V A Blinman T | 1993 | Ann Surg1993，217，5： | 1 |
| 20 | Luminescence characteristics of zinc oxide nanocrystals deposited on glass via a solution method显示文摘 | Mastro M A Freitas J A Jr Eddy C R Jr | | 0，，03： | 1 |
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