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| 1 | Repression of Cell Proliferation by miR319-Regulated TCP4显示文摘叶开发广泛地在基因水平上被学习了。然而,很少对在 thedevelopmental 管理者和最终影响叶形式和尺寸的细胞周期 machinerya 连接之间的相互影响被知道。miR319 是调整涉及多重发展小径的 TCP 抄写因素的 conservedmicroRNA,包括叶 developmentand 老朽,机关弯曲,和荷尔蒙生合成并且发信号。这里,我们在房间增长的 thecontrol 分析 TCP4 的参予。TCP4 活动的小增加在叶细胞数字上有立即的影响,由 significantlyreducing 细胞增长。有高 TCP4 层次的植物在知道是房间周期的 activein G2-M 阶段的基因的表示有强壮的减小。这些效果的部分被 miR396 的正式就职调停,它镇压 Growth-RegulatingFactor (GRF ) 抄写因素。详细分析揭示了 TCP4 是 MIR396b 的一个直接管理者。然而,我们发现 TCP4 能通过另外的小径控制房间增长,并且我们识别了直接 connectionbetween TCP4 和 ICK1/KRP1,涉及房间周期的前进的基因。我们的结果证明 TCP4 能激活不同小径那 represscell 增长。 | Carla Schommer Juan M. Debernardi Edgardo G. Bresso Ramiro E. Rodriguez Javier F. Palatnik | 2014 | Molecular Plant2014，7，10： | 25 |
| 2 | Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population显示文摘AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1)in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.RESULTS: We studied 330 consecutive, non-selected,primary gastric carcinomas. Among these, there were173 male and 157 female patients (male/female ratio1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.CONCLUSION: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population. | Roberto Herrera-Goepfert Suminori Akiba Chihaya Koriyama Shan Ding Edgardo Reyes Tetsuhiko Itoh Yoshie Minakami Yoshito Eizuru | 2005 | World Journal of Gastroenterology2005，11，39： | 14 |
| 3 | 磁化率各向异性的原理及应用实例显示文摘磁化率各向异性(AMS)在地质领域中的应用极为广泛,可以用来研究古流向造成的磁性矿物的定向排列,以及构造应力作用引起的岩石内磁性矿物的定向重结晶、定向排列及韧性变形。本文介绍了AMS的基本原理和参数,并并介绍了前人及作者应用AMS详细分析研究了二个实例:(1)以假多畴(MD)高钛磁铁矿为主要载磁矿物的玄武岩样品的AMS变化及其对构造运动的响应;(2)以MD磁铁矿为主要载磁矿物的湖泊沉积物样品在沉积过程中AMS变化。AMS可以灵敏地检测样品中磁性矿物的定向排列,因此在在地质领域中具有很好的应用前景。 | 张淑伟 杨振宇 王喜生 Maria TCioppa 乔彦松 霍俊杰 Edgardo Caón-Tapia 赵越 | 2017 | 地质力学学报2017，23，1： | 10 |
| 4 | After having changed the treatment of heart failure with reduced ejection fraction: what are the latest evidences with sacubitril valsartan?显示文摘1 Introduction Sacubitril/valsartan(SV)is a first in class dual action molecule of the neprilysin(NEP)inhibitor prodrug sacubitril(AHU377)and the angiotensin II receptor(Ang-II)type 1 antagonist valsartanJ11 It is the first angiotensin receptor-neprilysin inhibitor(ARNI)whose pharmacodynamic effects are consistent with a simultaneous stimulation of the natriuretic peptides system(via NEP inhibition)and the blockade of the renin-angiotensin-aldosterone system(valsartan effect)that finally results in systemic vasodilation,increased diuresis and natriuresis,reduction of plasmatic volume and diminution of peripheral vascular resistance. | Edgardo Kaplinsky | 2019 | Journal of Geriatric Cardiology2019，16，2： | 5 |
| 5 | Changing the treatment of heart failure with reduced ejection fraction: clinical use of sacubitril-valsartan combination显示文摘尽管有重要治疗学的进展,有长期的心失败(HF ) 的病人在病态和死亡的高风险留下。Sacubitril valsartan (以前作为 LCZ696 知道) 一个新口头的代理人与减少的喷射在成年人为征兆的长期的心失败的治疗被同意部分。自从它合并 neprilysin 禁止者, sacubitril 和血管收缩素 II,它在班血管收缩素受体 neprilysin 禁止者(ARNI ) 被描述为第一受体对手, valsartan。Neprilysin 是包括 natriuretic 毁坏几 vasoactive 肽的 endopeptidase 肽(NP ) , bradykinin, endothelin 和血管收缩素 II (Ang-II ) 。因此,它的抑制的自然后果是两个, NP 和 Ang-II 的 plasmatic 层次的增加(随相反的生物行动) 。那么,这些的联合抑制两个系统(Sacubitril / valsartan ) 可以在 HF 提高 NP 效果的好处(natriuresis,多尿,等等) 当 Ang-II 受体被禁止时(减少的血管缩小和醛固酮版本) 。在大临床的试用(与 8442 个病人一起的 PARADIGM-HF ) ,这个新代理人被发现显著地减少心血管,所有由于 HF 象住院一样引起死亡(与 enalapril 相比) 。这张手稿为 sacubitril valsartan, dosing 和小心考察临床的证据,在有减少的喷射的 HF 的治疗的未来方向和它的考虑地方部分。 | Edgardo Kaplinsky | 2016 | Journal of Geriatric Cardiology2016，13，11： | 4 |
| 6 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 7 | Acute coronary syndrome: a rare case of multiple endocrine neoplasia syndromes with pheochromocytoma and medullary thyroid carcinoma显示文摘Pheochromocytoma is a tumor arising from neuroectodermal chromaffin tissues in the adrenal gland or extra-adrenal paraganglia(paragangliomas). The prevalence of the tumor is 0.1%-0.6% in the hypertensive population, of which 10%-20% are malignant. Pheochromocytoma produces, stores, and secretes catecholamines, as well as leads to hypertensive crisis, arrhythmia, angina, and acute myocardial infarction without coronary artery diseases. We report a case of acute coronary syndrome(ACS) with a final diagnosis of multiple endocrine neoplasia with pheochromocytoma and medullary thyroid carcinoma(MTC). | Alessadro Maloberti Paolo Meani Roberto Pirola Marisa Varrenti Marco Boniardi Anna Maria De Biase Paola Vallerio Edgardo Bonacina Giuseppe Mancia Paola Loli Cristina Giannattasio | 2015 | Cancer Biology & Medicine2015，12，3： | 4 |
| 8 | Biosorption of mercury by Macrocystis pyrifera and Undaria pinnatifida:Influence of zinc,cadmium and nickel显示文摘This study investigated the adsorption of Hg(Ⅱ) on Macrocystis pyrifera and Undaria pinnatifida in monometallic system in the presence of Zn(II),Cd(Ⅱ) and Ni(II).The two biosorbents reached the same maximum sorption capacity (q m = 0.8 mmol/g) for mercury.U.pinnatifida showed a greater affinity (given by the coefficient b of the Langmuir equation) for mercury compared to M.pyrifera (4.4 versus 2.7 L/mmol).Mercury uptake was significantly reduced (by more than 50%) in the presence of competitor heavy metals such as Zn(II),Cd(II) and Ni(Ⅱ).Samples analysis using an environmental scanning electron microscopy equipped with an energy dispersive X-ray microanalysis showed that mercury was heterogeneously adsorbed on the surface of both biomaterials,while the other heavy metals were homogeneous distributed.The analysis of biosorbents by Fourier transform infrared spectrometry indicated that Hg(Ⅱ) binding occurred on S=O (sulfonate) and N-H (amine) functional groups. | Josefina Plaza Marisa Viera Edgardo Donati Eric Guibal | 2011 | Journal of Environmental Sciences2011，23，11： | 3 |
| 9 | Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution显示文摘瞄准:在墨西哥 ulcerative (UC ) 的一件样品估计流行和 p-ANCA 的临床的价值病人。方法:在一个未来的、同意 IRB 的协议, p-ANCA 与 UC 在 80 个病人被决定(吝啬的年龄, 32 +/- 12.9 年) 。疾病的严厉和延期被临床的方法决定,寻找有 p-ANCA 地位的一个统计协会。结果:p-ANCA 在 41 被检测(51%) 病人。疾病的严厉是统计上与他们的存在联系的唯一的临床的变量(P <
0.0001;或 = 9;CI 95%= 3.2-24.7 ) 。结论:p-ANCA 的流行类似于在另外的国家报导了那。他们的存在被联系到 UC 严厉,但是比提供了没有更多的信息由临床的方法获得了。 | Jesus K Yamamoto-Furusho Takeshi Takahashi-Monroy Omar Vergara-Fernandez Edgardo Reyes Luis Uscanga | 2006 | World Journal of Gastroenterology2006，12，21： | 2 |
| 10 | PARADIGM-HF trial: will LCZ696 change the current treatment of systolic heart failure?显示文摘 | Edgardo Kaplinsky | 2015 | Journal of Geriatric Cardiology2015，12，5： | 2 |
| 11 | Hereditary pancreatitis:An updated review in pediatrics显示文摘Hereditary Pancreatitis(HP)has emerged as a significant cause of acute,acute recurrent and chronic pancreatitis in the pediatric population.Given that it presents similarly to other causes of pancreatitis,a positive family history and/or isolation of a gene mutation are vital in its designation.Inheritance patterns remain complex,but mutations involving the PRSS1,SPINK1,CFTR and CTRC genes are commonly implicated.Since being first described in 1952,dozens of genetic alterations that modify the action of pancreatic enzymes have been identified.Among children,these variants have been isolated in more than 50%of patients with chronic pancreatitis.Recent research has noted that such mutations in PRSS1,SPINK1 and CFTR genes are also associated with a faster progression from acute pancreatitis to chronic pancreatitis.Patients with HP are at increased risk of developing diabetes mellitus,exocrine pancreatic insufficiency,and pancreatic adenocarcinoma.Management follows a multi-disciplinary approach with avoidance of triggers,surveillance of associated conditions,treatment of pancreatic insufficiency and use of endoscopic and surgical interventions for complications.With significant sequela,morbidity and a progressive nature,a thorough understanding of the etiology,pathophysiologic mechanisms,diagnostic evaluation,current management strategies and future research considerations for this evolving disease entity in pediatrics is warranted. | Arvind Vasant Panchoo Grant H VanNess Edgardo Rivera-Rivera Trevor J Laborda | 2022 | World Journal of Clinical Pediatrics2022，11，1： | 2 |
| 12 | Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical and epidemiological evidence显示文摘 | Edgardo Somigliana Paola Vigano’ Fabio Parazzini Sandra Stoppelli Erika Giambattista Paolo Vercellini | 2005 | Gynecologic Oncology2005，，2： | 2 |
| 13 | Iron Activation of Natural Aluminosilicates to Remove Arsenic from Groundwater显示文摘 | Irma Lia Botto Maria Jose Gonzalez Delia Gazzolli Edgardo Luis Soto | 2013 | Journal of Environmental Science and Engineering(A)2013，2，12： | 2 |
| 14 | Membrane redistributions through multi-intercellular exchanges and serial trogocytosis显示文摘Trogocytosis 是在膜的房间之间的快速的转移并且联系蛋白质。Trogocytic 交换在不同房间类型之间被调查了,主要在二房间的系统,包含一个施主和一种领受人房间类型。这里,我们在一个更复杂的系统学习了 trogocytosis,包含不仅几个有免疫力的房间子集而且多重肿瘤房间。我们证明 CD4+ T 房间, CD8+ T 房间和单核白血球能获得膜补丁和他们由多重同时的 trogocytoses 从不同肿瘤房间包含的未经触动的蛋白质。CD4+ 和 CD8+ T 房间的 trogocytic 能力被发现类似于自体同源的单核白血球的,却劣等。激活的外部血的 mononuclear 房间(PBMC ) 可以也在一个所有自体同源的系统交换在自己之间的膜。为这个原因,单核白血球能够从多重肿瘤房间来源获得膜,并且再把他们转移到自体同源的 T 房间,与一些他们的自己的膜(连续 trogocytosis ) 一起。我们的数据说明在自体同源的激活的有免疫力的受动器房间和他们的环境之间的膜交换的程度,并且包括鈥渂y stander 鈥 ? 房间,本地环境的细胞的内容怎么可以影响有免疫力的受动器房间的功能。 | Estlbahz Alegre Klave-Yune HoWangYin Benolt Favier Jeremy Baudhuin Emilie Lesport Marina Daouya Alvaro Gonzalez Edgardo D Carosella Joel LeMaoult | 2010 | Cell Research2010，20，11： | 2 |
| 15 | Should endometriomas be treated before IVF - ISCI cycles显示文摘 | Edgardo S Paolo V Paola V | 2006 | Hum Reprod Update2006，12，1： | 1 |
| 16 | The role of HLA-G in immunity and hematopoiesis 显示文摘 | EDGARDO D CAROSELLA SILVIA GREGORI NATHALIE ROUAS-FREISS | 2011 | Cellular and Molecular Life Sciences2011，68，3： | 1 |
| 17 | Selection of thermotolerant yeast strains Saccharomyces cerevisiae for bioethanol production 显示文摘 | Edgardo A Carolina P Manuel R | 2008 | Enzyme and Technology Microbial2008，，43： | 1 |
| 18 | A comparative study of diesel analysis by FTIR, FTNIR and FT-Raman spectroscopy using PLS and artificial neural network analysis显示文摘 | Vianney O. Santos Flavia C.C. Oliveira Daniella G. Lima Andrea C. Petry Edgardo Garcia Paulo A.Z. Suarez Joel C. Rubim | 2005 | Analytica Chimica Acta2005，，2： | 1 |
| 19 | A combined bacterial process for the reduction and immobilization of chromium 显示文摘 | Viera Marisa Curutchet Gustavo Donati Edgardo | 2003 | International Biodeterioration & Biodegradation2003，52，1： | 1 |
| 20 | Epidemiology of postpartum haemorrhage: a systematic review 显示文摘 | Guillermo C Cristina C Edgardo A | 2008 | Best Prac Res Clin Obstet Gynaecol2008，22，6： | 1 |
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