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| 1 | Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy显示文摘Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in patients.Independent of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic dysfunction.Although the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile dysfunction.Multiple subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological stresses.These changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium sensitivity.In this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus. | Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson | 2015 | World Journal of Diabetes2015，6，7： | 10 |
| 2 | 显示文摘 | Edgley D S Saje B Platts A E | 1994 | J Magn Magn Mater1994，138，： | 1 |
| 3 | Yeast water relations: physiological changes induced by solute stress in Saccharomyces cerevisiae and Saccharomyces rouxii显示文摘 | Edgley M Brown A D | 1983 | J Gen Microbiol1983，129，： | 1 |
| 4 | Characterisation of high temperature oxidation of Nd-Fe-B magnets 显示文摘 | EDGLEY D S LE BRETON J M STEYAERT S | 1997 | Journal of Magnetism and Magnetic Materials1997，173，12： | 1 |
| 5 | Changes in de- scending motor pathway connectivity after corticospinal tract lesion in macaque monkey 显示文摘 | Zaaimi B Edgley SA Soteropoulos DS | 2012 | Brain2012，135，7： | 1 |
| 6 | Acute Rho-kinase inhibition improves coronary dysfunction in vivo,in the early diabetic microcirculation 显示文摘 | Pearson JT Jenkins MJ Edgley AJ | 2013 | Cardiovascular Diabetolo- gy2013，12，1： | 1 |
| 7 | Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor - 13 显示文摘 | Edgley A J Krum H Kelly DJ | 2012 | Car- diovasc Ther2012，30，1： | 1 |
| 8 | The politics of recovery in mental health: A left libertarian policy analy- sis显示文摘 | Edgley A Stickley T Wright N | 2012 | Social Theory & Health2012，10，2： | 1 |
| 9 | New polymer bonded magnet显示文摘 | Leberton J M Steyaert S | 1997 | J Magn Magn Mat1997，173，： | 1 |
| 10 | Yeast water relations:physiological changes induced by solute stress in 5accharomyces cerevisiae and Saccharomyces rouxii显示文摘 | Edgley M Brown A D | | 0，，： | 1 |
| 11 | Effect of additions of Nb to Sm2Fe17-based cast alloys 显示文摘 | Siana S A Edgley D S Harris I R | 1995 | J Alloys Compds1995，226，： | 1 |
| 12 | Desperately seeking sociology: nursing student perceptions of sociology on nursing courses显示文摘 | Edgley A Timmons S Crosbie B | 2009 | Nurse Educ Today2009，29，1： | 1 |
| 13 | Chronic Rho-ki- nase inhibition improves left ventricular contractile dysfunction in early type-I diabetes by increasing myosin cross-bridge extension 显示文摘 | Waddingham MT Edgley AJ Astolfo A | 2015 | Cardiovasc Diabetol2015，22，14： | 1 |
| 14 | Desperately seeking sociology:nursing student perceptions of sociology on nursing courses显示文摘 | Edgley A Timmons S Crosbie B | 2009 | Nurs Educ Today2009，29，1： | 1 |
| 15 | Direct and indirect connections with upper limb motoneurons from the primate reticulospinal tract 显示文摘 | Riddle CN Edgley SA Baker SN | 2009 | J Neurosci2009，29，15： | 1 |
| 16 | Lack of evidence for direct corticospinal contributions to control of the ipsi- lateral forelimb in monkey显示文摘 | Soteropoulos DS Edgley SA Baker SN | 2011 | J Neurosci2011，31，11： | 1 |
| 17 | Protein kinase C- beta inhibition attenuates the progression of nephropathy in non- diabetic kidney disease显示文摘 | Kelly DJ Edgley A J Zhang Y | 2009 | Nephrol Dial Transplant2009，24，： | 1 |
| 18 | Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans 显示文摘 | Maydan J S Loreh A Edgley M L | 2010 | BMC Genomies2010，11，： | 1 |
| 19 | Characterisation of high temperature oxidation of Nd- Fe-B magnets 显示文摘 | Edgley D S Le Breton J M Steyaert S Anmed F M Harris I R Teillet J | 1997 | Journal of Magnetism and Magnetic Materials1997，173，： | 1 |
| 20 | Targeting fibrosis for the treatment ofheart failure: a role for transforming growth factor-beta显示文摘 | Edgley AJ Krum H Kelly DJ | 2012 | Cardiovasc Ther2012，30，1： | 1 |
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