|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Use of blood based biomarkers in the evaluation of Crohn's disease and ulcerative colitis显示文摘Despite significant improvements in our understanding of Crohn's disease(CD) and ulcerative colitis(UC) in recent years, questions remain regarding the best approaches to assessment and management of these chronic diseases during periods of both relapse and remission. Various serologic biomarkers have been used in the evaluation of patients with both suspected and documented inflammatory bowel disease(IBD), and while each has potential utility in the assessment of patients with IBD, potential limitation remain with each method of assessment. Given these potential shortcomings, there has been increased interest in other means of evaluation of patients with IBD, including an expanding interest in the role of gene expression profiling. Among patients with IBD, gene expression profiles obtained from whole blood have been used to differentiate active from inactive CD, as well as to differentiate between CD, UC, and non-inflammatory diarrheal conditions. There are many opportunities for a non-invasive, blood based test to aid in the assessment of patients with IBD, particularly when considering more invasive means of evaluation including endoscopy with biopsy. Furthermore, as the emphasis on personalized medicine continues to increase, the potential ability of gene expression analysis to predict patient response to individual therapies offers great promise. While whole blood gene expression analysis may not completely replace more traditional means of evaluating patients with suspected or known IBD, it does offer significant potential to expand our knowledge of the underlying genes involved in the development of these diseases. | Edward L Barnes Choong-Chin Liew Samuel Chao Robert Burakoff | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 1 |
| 2 | Lifestyle monitoring:Technology for supported independence显示文摘 | Barnes N M Edwards N H Rose D A D | 1998 | IEEE Computing and Control Engineering Journal1998，169，174： | 1 |
| 3 | Measurement of astigmatism arisingfrom the internal ocular surfaces显示文摘 | Dunne MCM Edward MEA Barnes DA | 1996 | Acta Ophthalmol1996，74，： | 1 |
| 4 | Lifestyle monitoring : Technology for supported independence 显示文摘 | Barnes N M Edwards N H Rose D A D | 1998 | IEE Computing and Control Engineering Journal1998，169，174： | 1 |
| 5 | Quality of Life in Patients With Brain Metastases Using the EORTC QLQ-BN20+2 and QLQ-C15-PAL显示文摘 | Amanda Caissie Janet Nguyen Emily Chen Liying Zhang Arjun Sahgal Mark Clemons Marc Kerba Palmira Foro Arnalot Cyril Danjoux May Tsao Elizabeth Barnes Lori Holden Brita Danielson Edward Chow | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 6 | Bibliotherapy and Perceptions of Death by Young Children显示文摘 | Jeffrey Todahl Thomas Edward Smith Michael Barnes M. Grace Alves Pereira | 1998 | Journal of Poetry Therapy1998，，2： | 1 |
| 7 | A study of the axis of oriention of residual astigmatism显示文摘 | Dunne MCM Edward MEA Barnes DA | 1994 | Acta Ophthalmol1994，72，： | 1 |
| 8 | Lifestyle monitoring: Technology for supported independence显示文摘 | BARNES N M EDWARDS N H ROSE D A D | 1998 | IEEE Computing and Control Engineering Journal1998，169，174： | 1 |
| 9 | Wearable, Bluetooth-enabled system for home health care显示文摘 | Edward Barnes Steve Warren | 2002 | EMBS/BMES Conference2002，，： | 1 |
| 10 | In-process vibrational spectroscopy and ultrasound measurements in polymer melt extrusion显示文摘 | P.D. Coates S.E. Barnes M.G. Sibley E.C. Brown H.G.M. Edwards I.J. Scowen | 2003 | Polymer2003，，19： | 1 |
| 11 | A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States groundwater显示文摘 | Kimberlee K Barnes Dana W Kolpin Edward T Furlong | 2008 | Science of the Total Environment2008，9，402： | 1 |
| 12 | Development of near-eutectic Al-Si casting alloys for piston applications显示文摘 | EDWARDS W M THOMSON R C BARNES S J | 2002 | Materials ScienceForum2002，，2： | 1 |
| 13 | In-process vibration spectroscopy and ultrasound measurements in polymer melt extrusion 显示文摘 | Coates P D Barnes S E Sibley M G Brown E C Edwards H G M Scowen I J | 2003 | Polymer2003，，44： | 1 |
| 14 | Human epidermal growth factor receptor-2 in oesophageal cancers:An observational study显示文摘AIM:To determine the incidence of human epidermal growth factor receptor 2(HER2) over expression in oesophageal cancers.METHODS:A retrospective study,of one hundred consecutive cases of endoscopic histological samples of oesophageal cancers from a single British cancer network were included.Cancer cases were diagnosed between April 2007 and June 2010.HER2 over expression was assessed using immunohistochemistry,those that scored '0' and '+1' were considered 'negative' for HER2;those that scored '+3' were considered 'Positive'.Cases that were scored '+2' on immunohistochemistry further went on to have HER2 gene analysis using the Ventana HER brightfield dual-colourin situ hybridisations(HER B DISH) assay and either came back to be positive or negative for HER2 over expression.Overall survival was measured from date of histological diagnosis until date of death.93% of the cases were followed up till five years or death,and all were followed up till two years.Cases of gastro-oesophageal junctional tumours were excluded.RESULTS:The median age of our sample was 66 years(range:38-91 years).Eighty one were male and 19 female.Ninety-one of the cases were adenocarcinoma of the oesophagus and the rest were cases of squamous cell carcinoma.The anatomical distribution of the tumours was;upper oesophagus 2,middle oesophagus 11,and 87 were in the lower oesophagus.Operative resection was completed in 15 cases;seven cases had attempted surgical resections,i.e.,open and close,33 patients received definitive chemo-radiation and 52 had palliative treatment.Twenty-five of the cancers showed evidence of HER2 over expression,all were adenocarcinomas.Of the 25 cases that showed evidence of HER2 over expression,21(84%) were located in the lower third of the oesophagus.On staging,24 out of the 25 HER2 positive cases were at stage 3 or more(13 at stage 3 and 11 at stage 4),For HER2 negative cases 37 were at stage 3 and 32 were staged as stage 4.Seventeen out of twenty five cases(68%) with HER2 over expression received palliative therapy,in comparison to thirty five out of seventy five(46.7%) in tumours not expressing HER2.No significant difference in overall survival was demonstrated between patients whose cancers showed evidence of HER2 over expression and those who did not;median overall survival for HER2 positive tumours was 15 mo(95%CI,11-19 mo) compared to 13 mo(95%CI,9-17 mo) for HER2 negative ones.Two years cumulative survival for cases with HER2 over expression was 33.7% compared to 31.6% in cases without HER2 over expression(P = 0.576).Only cancer's stage significantly affected overall survival on both univariant and multivariable analysis(P = 0.034 and P = 0.009 respectively).None of the patients included in this study received Trastuzumab.CONCLUSION:Twenty-seven point five percent of oesophageal adenocarcinomas showed evidence of HER2 over expression.Routine testing for human HER2 in oesophageal adenocarcinomas can have significant implication on treatments offered to patients that may potentially affect their prognosis. | Hazem Al-Momani Rachel Barnes Ahmed El-Hadi Rachit Shah Wyn G Lewis Paul Edwards | 2012 | World Journal of Gastroenterology2012，18，44： | 1 |
| 15 | A Methodology for Benchmarking Real Time Kinematic GPS 显示文摘 | EDWARDS S J CROSS P A BARNES J B | 1999 | Surv Rev1999，35，273： | 1 |
| 16 | A Methodology for Benchmarking Real-time Kinematic GPS显示文摘 | Edwards S J Cross P A Barnes J B | 1999 | Surv Rev1999，35，273： | 1 |
| 17 | Neuropsychiatric symptoms in mild cognitive impairment:differences by subtype and progression to dementia显示文摘 | Edwards ER Spira AP Barnes DE | 2009 | Int J Geriatr Psychiatry2009，24，： | 1 |
| 18 | Neuropsychiatric symptoms in mild cognitive impairment:differences by subtype and progression to dementia显示文摘 | Edwards ER Spira AP Barnes DE | 2009 | Int J Geriatr Psychiatry2009，24，7： | 1 |
| 19 | Errors in Drug Computations During Newborn Intensive Care显示文摘 | Callion C White M Barnes B Edwards NK | 1979 | Am Dis Child1979，133，： | 1 |
| 20 | Neural cell adhesion molecule in adenoid cystic carcinoma invading the skull base显示文摘 | Kapadia SB Barnes L | 1997 | Otolaryngol Head Neck Surg1997，117，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员