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| 1 | 美国内燃机油新规格对粘度指数改进剂的挑战显示文摘过去20年低温泵送性是发动机油重要的指标,但是历来都只针对新油,最近才对使用后油的有所要求。受到各种因素的影响,在发动机整个使用过程中油品低温泵送性可能变得很差。本文使用工业发动机以及专用的发动机试验来考察使用后油品的低温泵送性,特别考察了粘度指数改进剂对其的影响。实验表明:使用某些种类的粘度指数改进剂其使用后油品可保持不错的低温泵送性能,而使用另一类粘度指数改进剂则使用后油品的低温泵送性变差,尽管他们的低温启动性并不受到多大影响,降凝剂也对用后油低温泵送性影响不大。 | Jai G.Bansal Chin Chu Edward F.Outten 杨道胜 史宗冈 范亦工 | 2005 | 润滑油2005，20，1： | 7 |
| 2 | 胸苷酸合成酶表达调控的分子机制显示文摘胸苷酸合成酶(thymidylate synthase,TS)是生物体内催化胸苷酸合成所必需的酶,多年来一直作为肿瘤化疗的重要靶酶。对TS基因调控机制的研究表明:基因扩增、转录、翻译和翻译后过程都参与了TS表达的调控。先前的研究表明:TS可与自身的mRNA结合形成TS-mRNA复合物,使mRNA翻译受阻,5-氟尿嘧啶(5-fluorouracil,5-FU)等抗代谢药物可与TS蛋白结合,结合后的复合物不能与TS mRNA作用,导致体内TS的表达升高,是肿瘤细胞产生抗药性的重要分子机制之一。现对TS基因表达调控研究进展、翻译调控与抗药性产生的分子机制进行综述。 | 阎松 牛荣丽 CHU Edward 林秀坤 | 2005 | 细胞生物学杂志2005，27，2： | 5 |
| 3 | A Phase I Study of the Chinese Herbal Medicine PHY906 as a Modulator of Irinotecan-based Chemotherapy in Patients with Advanced Colorectal Cancer显示文摘 | Shivaani Kummar M. Sitki Copur Michal Rose Scott Wadler Joe Stephenson Mark O’Rourke Wayne Brenckman Robert Tilton Shwu-Huey Liu Zaoli Jiang Tahmun Su Yung-chi Cheng Edward Chu | 2011 | Clinical Colorectal Cancer2011，，2： | 1 |
| 4 | Oxaliplatin combinations as first-line therapy in advanced colorectal cancer显示文摘 | Kavita Maung Edward Chu Mace Rothenberg | 2002 | Clin Colorectal Cancer2002，2，2： | 1 |
| 5 | Improving the Accuracy of Automated GUI Testing for Embedded Systems显示文摘 | Lin Ying-Dar Chu Edward T-H Yu Shang-Che Lai Yuan-Cheng | 2014 | IEEE Software2014，，1： | 1 |
| 6 | Effect of IL28B Genotype on Early Viral Kinetics During Interferon-Free Treatment of Patients With Chronic Hepatitis C显示文摘 | Tom W. Chu Rohit Kulkarni Edward J. Gane Stuart K. Roberts Catherine Stedman Peter W. Angus Brett Ritchie Xiao-Yu Lu David Ipe Uri Lopatin Soren Germer Victor A. Iglesias Robert Elston Patrick F. Smith Nancy S. Shulman | 2012 | Gastroenterology2012，，4： | 1 |
| 7 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 8 | Optimization of Cooperative Sensing in Cognitive Radio Networks: A Sensing-Throughput Tradeoff View显示文摘 | Edward Chu Yeow Peh Liang Ying-Chang Guan Yongliang | 2009 | IEEE Transactions on Vehicular Technology2009，58，9： | 1 |
| 9 | Safety and Efficacy of Panitumumab Therapy After Progression With Cetuximab: Experience at Two Institutions显示文摘 | Muhammad Wasif Saif Kristin Kaley Edward Chu M. Sitki Copur | 2010 | Clinical Colorectal Cancer2010，，5： | 1 |
| 10 | Emerging roles of Aurora-A kinase in cancer therapy resistance显示文摘Aurora kinase A(Aurora-A),a serine/threonine kinase,plays a pivotal role in various cellular processes,including mitotic entry,centrosome maturation and spindle formation.Overexpression or gene-amplification/mutation of Aurora-A kinase occurs in different types of cancer,including lung cancer,colorectal cancer,and breast cancer.Alteration of Aurora-A impacts multiple cancer hallmarks,especially,immortalization,energy metabolism,immune escape and cell death resistance which are involved in cancer progression and resistance.This review highlights the most recent advances in the oncogenic roles and related multiple cancer hallmarks of Aurora-A kinase-driving cancer therapy resistance,including chemoresistance(taxanes,cisplatin,cyclophosphamide),targeted therapy resistance(osimertinib,imatinib,sorafenib,etc.),endocrine therapy resistance(tamoxifen,fulvestrant) and radioresistance.Specifically,the mechanisms of Aurora-A kinase promote acquired resistance through modulating DNA damage repair,feedback activation bypass pathways,resistance to apoptosis,necroptosis and autophagy,metastasis,and stemness.Noticeably,our review also summarizes the promising synthetic lethality strategy for Aurora-A inhibitors in RB1,ARID1A and MYC gene mutation tumors,and potential synergistic strategy for m TOR,PAK1,MDM2,MEK inhibitors or PD-L1 antibodies combined with targeting Aurora-A kinase.In addition,we discuss the design and development of the novel class of Aurora-A inhibitors in precision medicine for cancer treatment. | Dayong Zheng Jun Li Han Yan Gang Zhang Wei Li Edward Chu Ning Wei | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 1 |
| 11 | Purification and Characterization of Staphylococcal Enterotoxin A*显示文摘 | CHU FUN SUN THADHANI KALOO SCHANTZ EDWARD J | | 0，，10： | 1 |
| 12 | Solvothermal synthesis of N-doped TiO2 nanotubes for visible-light-responsive photocatalysis显示文摘 | JIANG Zheng YANG Fan LUO Nian-jun CHU B T T SUN De-yin SHI Hua-hong XIAO Tian-cun EDWARDS P P | 2008 | Chemical Communications2008，，47： | 1 |
| 13 | Sensing-throughput tradeoff for cognitive radio networks显示文摘 | Liang Ying-chang Zeng Yong-hong Edward Chu Yeow Peh | 2008 | IEEE Transactions on Wireless Communications2008，7，4： | 1 |
| 14 | Hepatic Resection for Hepatocellular Carcinoma An Audit of 343 Patients显示文摘 | Edward C. S. Lai Sheung-Tat Fan Chung-Mau Lo Kent-Man Chu Chi-Leung Liu John Wong | 1995 | Annals of Surgery1995，，3： | 1 |
| 15 | A Review of Simulation Studies on Supply Chain Management显示文摘 | Edward Chu | 2003 | Journal of Academy of Business and Economics2003，2，1： | 1 |
| 16 | Oxaliplatin combinations as first-line therapy in advanced colorectal cancer显示文摘 | Kavita Maung Edward Chu Mace Rothenberg | 2002 | Clin Colorectal Cancer2002，2，2： | 1 |
| 17 | Functional interaction of Purα with the Cdk2 moiety of cyclin A/Cdk2显示文摘 | Hong Liu Sharon M. Barr Caryn Chu D. Stave Kohtz Yayoi Kinoshita Edward M. Johnson | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 18 | Hepatic resection for hepatocellular carcinoma: An audit of 343 patients显示文摘 | Lai Edward Fan Sheung-Tat Chu Kent Man | 1995 | Annals of Surgery1995，221，3： | 1 |
| 19 | Oral health status and behav- iors of preschool children in Hong Kong 显示文摘 | CHU CH HO PL EDWARD CM LO | 2012 | BMC Public Heahh2012，12，1： | 1 |
| 20 | Nodules of less-differentiated tumor within or adjacent to hepatocellular carcinoma: Relative expression of transforming growth factor-α and its receptor in the different areas of tumor显示文摘 | Yosuke Morimitsu Chu Chieh Hsia Masamichi Kojiro Edward Tabor | 1995 | Human Pathology1995，，10： | 1 |
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