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| 1 | 1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine beta-synthase显示文摘 | Kriebitzsch C Verlinden L Eelen G | | 0，，12： | 1 |
| 2 | A time course analysis of the affective priming effect显示文摘 | Hermans D Houwer JD Eelen P | | 0，，02： | 1 |
| 3 | Affective and identity priming with episodically associated stimuli显示文摘 | Houwer J D Hermans D Eelen P | | 0，，02： | 1 |
| 4 | The impact of 1, 25 (OH)2D3 and its structural analogs on gene expression in cancer cells--a microarray approach 显示文摘 | Kriebitzsch C Vefilinden L Eelen G | 2009 | Anticancer Res2009，29，9： | 1 |
| 5 | The E2F regulated gene Chkl is highly expressed in triple-negative estrogen receptor/proges- terone receptor/HER-2 breast carcinomas 显示文摘 | Vedinden L Vanden Bempt I Eelen G | 2007 | Cancer Res2007，67，14： | 1 |
| 6 | The effects of 1alpha,25-dihydroxyvitamin D3 on the expression of DNA replication genes显示文摘 | Eelen G Verlinden L van Camp M | | 0，，01： | 1 |
| 7 | The anti-cancer and anti-inflammatory actions of 1,25 (OH) 2 D3 显示文摘 | Vanoirbeek E Krishnan A Eelen G | 2011 | Best Praet Res Clin Endoerinol Metab2011，25，4： | 1 |
| 8 | Persistence, mobility, and adsorption of the herbicide flufenacet in the soil of winter wheat crops显示文摘 | Rouchaud O Neaus H Eelen | 2001 | Bull Environ Contain Tocicol2001，67，： | 1 |
| 9 | Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor显示文摘 | Eelen G Valle N Sato Y | 2008 | Cbem Biol2008，15，10： | 1 |
| 10 | An affective variant of the simon paradigm显示文摘 | Houwer J D Eelen P | 1998 | Cognition and emotion1998，12，1： | 1 |
| 11 | A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds显示文摘The growth of solid tumors depends on tumor vascularization and the endothelial cells(ECs)that line the lumen of blood vessels.ECs generate a large fraction of ATP through glycolysis,and elevation of their glycolytic activity is associated with angiogenic behavior in solid tumors.6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(PFKFB3)positively regulates glycolysis via fructose-2/6-bisphosphate,the product of its kinase activity.Partial inhibition of glycolysis in tumor ECs by targeting PFKFB3 normalizes the otherwise abnormal tumor vessels,thereby reducing metastasis and improving the outcome of chemotherapy.Although a limited number of tool compounds exist,orally available PFKFB3 inhibitors are unavailable.In this study we conducted a high-throughput screening campaign against the kinase activity of PFKFB3,involving 250,240 chemical compounds.A total of 507 initial hits showing>50%inhibition at 20μM were identified,66 of them plus 1 analog from a similarity search consistently displayed low IC50 values(<10μM).In vitro experiments yielded 22 nontoxic hits that suppressed the tube formation of primary human umbilical vein ECs at 10μM.Of them,15 exhibited binding affinity to PFKFB3 in surface plasmon resonance assays,including 3(WNN0403-E003,WNN1352-H007 and WNN1542-F004)that passed the pan-assay interference compounds screening without warning flags.This study provides potential leads to the development of new PFKFB3 inhibitors. | Jie Li Yan Zhou Guy Eelen Qing-tong Zhou Wen-bo Feng Viktorija Labroska Fen-fen Ma Hui-ping Lu Mieke Dewerchin Peter Carmeliet Ming-wei Wang De-hua Yang | 2023 | Acta Pharmacologica Sinica2023，44，3： | 1 |
| 12 | PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion,and anti-migration and-invasion activity of vitamin D显示文摘 | Vanoirbeek E Eelen G Verlinden L | 2014 | Oncogene2014，33，15： | 1 |
| 13 | FOXO1couples metabolic activity and growth state in the vascular endothelium显示文摘 | Wilhelm K Happel K Eelen G | 2016 | Nature2016，529，7585： | 1 |
| 14 | 1α, 25-dihydroxyvitamin D3- induced down regulation of the checkpoint proteins, Chkl and Claspin, is mediated by the pocket proteins p107 and p130显示文摘 | Yerlinden L Eelen G Hellemont RV | 2007 | J Steroid Biochem Mol Biol2007，103，： | 1 |
| 15 | The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor-/progesterone receptor ±/HER-2-breast carcinomas显示文摘 | Verlinden L Bempt IV Eelen G | 2007 | Cancer Res2007，67，14： | 1 |
| 16 | Affective and identity priming with episodically Associated Stimuli显示文摘 | Houwer J D Hennam D Eelen P | 1998 | Cognition And Emotion1998，12，2： | 1 |
| 17 | The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor-/progesterone receptor-/HER-2-breast carcinomas显示文摘 | Verlinden L Bempt IV Eelen G | 2007 | Cancer Res2007，67，14： | 1 |
| 18 | A Time Course Analysis of the Affective Filming effect显示文摘 | HermanS D Houwer J D Eelen P | 2001 | Cognifon And Ermtion2001，15，2： | 1 |
| 19 | Mechanism and potential of the growth-inhibitory actions of vitamin D and analogs显示文摘 | EELEN G GYSEMANS C VERLINDEN L | 2007 | Curr Med Chem2007，14，17： | 1 |
| 20 | Siol metabolism of isoxaflutole in corn显示文摘 | ROUCHAUD J NEUS O EELEN H | 2002 | Arch Environ Contam Toxicol2002，42，3： | 1 |
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