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| 1 | Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis显示文摘AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome(DIOS) in Israeli cystic fibrosis(CF) patients.METHODS: This is a multi-center,comparative,retrospective study in which we reviewed the medical records of all CF patients from three major CF centers in Israel who were treated in the period from 1980 to 2012.Patients diagnosed with DIOS were defined as the study group.The patients were diagnosed with DIOS based on their clinical presentation and typical findings on either abdominal X-ray or computerized tomography scan.For the control group,CF patients with no DIOS were matched to the patients in the study group for age,sex,and cystic fibrosis transmembrane conductance regulator(CFTR) mutations.For both groups,the collected data included age,sex,CFTR genotype,weight,height,and body mass index.Clinical data included respiratory function tests in the last five years prior to the study,respiratory function test immediately before and after the DIOS event,number of hospitalizations,sputum culture results,and CFrelated conditions diagnosed according to the CF clinical practice guidelines.In the study group,data on the DIOS treatment and tendency for DIOS recurrence were also analyzed.RESULTS: The medical charts for a total of 350 CF patients were reviewed.Of the 350 CF patients,26(7.4%) were diagnosed with DIOS.The control group included 31 CF patients with no DIOS diagnosis.The mean follow-up period was 21.6 ± 8.2 years.The total of DIOS episodes in the follow-up period was 60.The distribution of DIOS episodes was as follows: 6/26(23.1%) study patients had one episode of DIOS intheir lifetime,7/26(26.9%) had two episodes,7/26(26.9%) had three episodes,and 6/26(23.1%) had four or more episodes.Compared to the control group,DIOS patients had a significantly higher incidence of meconium ileus in the past(65.4% vs 0%,respectively,P < 0.02),more Aspergillus spp.colonization(34.6% vs 3.2%,respectively,P < 0.02),and a higher number of hospitalizations due to respiratory exacerbations(8.6 vs 6.2 mean total hospitalizations per follow-up period,respectively,P < 0.02).No other significant differences were found between the control and study groups.The conservative treatment of DIOS,which mainly includes hydration and stool softeners,was successful in 82% of the episodes.The survival rate was similar for both groups.CONCLUSION: CF patients with DIOS suffer from recurrent hospitalizations and airway pathogen acquisition.Although recurrence of DIOS is common,conservative treatment is successful in most patients. | Moran Lavie Tzipora Manovitz Daphna Vilozni Sarina Levy-Mendelovich Ifat Sarouk Ilana Weintraubv David Shoseyov Malena Cohen-Cymberknoh Joseph Rivlin Ori Efrati | 2015 | World Journal of Gastroenterology2015，21，1： | 10 |
| 2 | Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation显示文摘AIM:To evaluate the role of sequential therapy and Lactobacillus reuteri (L. reuteri ) supplementation, in the eradication treatment of Helicobacter pylori (H. pylori ). METHODS:H. pylori infection was diagnosed in 90 adult dyspeptic patients. Patients were excluded if previously treated for H. pylori infection or if they were taking a proton pump inhibitor (PPI), H2-receptor antagonist or antibiotics. Patients were assigned to receive one of the following therapies:(1) 7-d triple therapy (PPI plus clarithromycin and amoxicillin or metronidazole) plus L. reuteri supplementation dur- ing antibiotic treatment; (2) 7-d triple therapy plus L. reuteri supplementation after antibiotic treatment; (3) sequential regimen (5-d PPI plus amoxicillin therapy followed by a 5-d PPI, clarithromycin and tinidazole) plus L. reuteri supplementation during antibiotic treatment; and (4) sequential regimen plus L. reuteri supplementation after antibiotic treatment. Successful eradication therapy was defined as a negative urea breath test at least 4 wk following treatment. RESULTS:Ninety adult dyspeptic patients were en- rolled, and 83 (30 male, 53 female; mean age 57 ± 13 years) completed the study. Nineteen patients were administered a 7-d triple treatment:11 with L. reuteri supplementation during and 8 after therapy. Sixty-four patients were administered a sequential regimen:32 with L. reuteri supplementation during and 32 after therapy. The eradication rate was significantly higher in the sequential group compared with the 7-d triple regimen (88% vs 63%, P = 0.01). No difference was found between two types of PPI. No difference in erad- ication rates was observed between patients submitted to L. reuteri supplementation during or after antibiotic treatment. Compliance with therapy was excellent in all patients. No difference in adverse effects was observed between the different antibiotic treatments and between patients submitted to L. reuteri supplementation during and after antibiotic treatment. There was a low incidence of adverse effects in all groups of patients with sequential therapy, probably due to the presence of the L. reuteri supplementation. CONCLUSION:The sequential treatment regimen achieved a significantly higher eradication rate of H. pylori compared with standard 7-d regimen. L. reuteri supplementation could reduce the frequency and the intensity of antibiotic-associated side-effects. | Cesare Efrati Giorgia Nicolini Claudio Cannaviello Nicole Piazza O'Sed Stefano Valabrega | 2012 | World Journal of Gastroenterology2012，18，43： | 4 |
| 3 | Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease显示文摘Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease(AD):Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise.For example,AD,the most common form of dementia in the elderly,accounts for 60–80%of all dementia cases. | Ronit Shapira Shai Efrati Uri Ashery | 2018 | Neural Regeneration Research2018，13，5： | 3 |
| 4 | The effects of quality of working life (QWL) on employee behavioral responses显示文摘 | David Efraty M. Joseph Sirgy | 1990 | Social Indicators Research1990，，1： | 2 |
| 5 | Endotracheal tube cuff-small important part of a big issue显示文摘 | Shai Efrati Israel Deutsch Gabriel M. Gurman | 2012 | Journal of Clinical Monitoring and Computing2012，，1： | 2 |
| 6 | The contribution of intraoperative transinguinal laparoscopic examination of the contralateral side to the repair of inguinal hernias in children显示文摘 | Klin B Efrati Y Abu Kishk I | | 0，，02： | 1 |
| 7 | Pneumatic retinopexy for the repair of primary rhegmatogenous retinal detachment:a 10-year retrospective analysis显示文摘 | Fabian ID Kinori M Efrati M | | 0，，： | 1 |
| 8 | Neonatal periappendicular abscess - - updated treatment 显示文摘 | Efrati Y Peer A Klin B | 2003 | J Pediatr Surg2003，38，2： | 1 |
| 9 | Ventilator-associated pneumonia: current status and future recommendations显示文摘 | Efrati S Deutsch I Antonelli M | 2010 | J Clin Monit Comput2010，24，2： | 1 |
| 10 | Exercise challenge test in 3-to 6-year-old asthmatic children 显示文摘 | Vilozni D Bentur L Efrati O | 2007 | Chest2007，132，2： | 1 |
| 11 | Automatic Tuning of Decentralized PID Controllers for MIMO Processes 显示文摘 | Halevi Y Palmor Z J Efrati T | 1997 | J Proc Cont1997，7，2： | 1 |
| 12 | Ventilator-associated pneumonia: current status and future recommendations显示文摘 | Efrati S Deutsch I Antonelli M | 2010 | Clin Monit Comput2010，24，2： | 1 |
| 13 | Terlipressin as rescue therapy for intracable hypotension due to septic shock in children 显示文摘 | Matok I Vard A Efrati O | 2005 | Shock2005，23，： | 1 |
| 14 | Flexible bron- choscopy and bronchoalveolar lavage in pediatric patients with lung disease显示文摘 | Efrati O Sadeh-Gomik U Modan-Moses D | 2009 | Pediatr Crit Care Med2009，10，1： | 1 |
| 15 | Pharmacological prophylaxis of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt:a randomized controlled study显示文摘 | Riggio O Masini A Efrati C | | 0，，5： | 1 |
| 16 | Hyperbaric oxygen,oxidative stress, NO bioavailability and ulcer oxygenation in diabetic patients显示文摘 | Efrati S Gall N Bergan J | 2009 | Undersea Hyperb Med2009，36，1： | 1 |
| 17 | Ventilator-associated pneu- monia: current status and future recommendations显示文摘 | Efrati S Deutseh I Antonelli M | 2010 | J Clin Monit Comput2010，24，： | 1 |
| 18 | Effect of various clinical varia- bles on total intracellular magnesium in hospitalized normomag- nesemic diabetic patients before discharge 显示文摘 | Gorelik O Efrati S Berman S | 2007 | Biol Trace Elem Res2007，120，13： | 1 |
| 19 | PPAR-gamma activation inhibits angiotensin Ⅱ synthesis, apoptosis,and proliferation of mesangial cells from spontaneously hypertensive rats显示文摘 | Efrati S berman S Ilgiyeav E | 2007 | Nephron Exp Nephrol2007，106，： | 1 |
| 20 | Rosiglitazone treatment attenuates renal tissue inflammation generated by urinary tract obstruction显示文摘 | Efrati S Berman S Chachashvili A | 2009 | Nephrology (Carlton)2009，14，2： | 1 |
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