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| 1 | Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat显示文摘Background:Current animal models of chronic pancreatitis(CP)often provide only limited pathophysio-logical insights since they incompletely reflect the human disease.CP induced by injection of dibutyltin dichloride(DBTC-pancreatitis)shares with human CP the important feature of extended fibrosis and would be an even more attractive model if it could be transferred from rats to mice,as recently sug-gested in the context of combined ethanol and DBTC application.This study aimed to evaluate the effects of DBTC in pancreas and liver of C57BL/6 mice,a strain commonly used to engineer genetic mouse mod-els.Methods:C57BL/6 mice and Lewis rats were exposed to variable doses of DBTC.After an investigation period of up to 4 weeks,laboratory findings and histopathological changes of pancreas and liver were evaluated.Results:Chronic DBTC-pancreatitis in rats was characterized by acinar cell damage,ductal changes,fi-brosis,and inflammatory cell infiltrates.Mice treated with DBTC at 6–8 mg/kg body weight,the standard doses in rats,showed transient increases of lipase activities but no morphological signs of chronic DBTC-pancreatitis 4 weeks after injection of the drug.Increased doses of 10–12 mg/kg DBTC were intolerable due to their high toxicity.In contrast,mice and rats presented with a similar histopathology of the liver that can be characterized as a chronic-proliferative DBTC-cholangitis with predominating damage and proliferation of the small bile ducts as well as secondary portal inflammatory cell infiltrates and a begin-ning portal fibrosis.Conclusions:The DBTC-model cannot be transferred from rats to C57BL/6 mice with respect to chronic DBTC-pancreatitis,but might be of interest to study DBTC-cholangitis in both species. | Friederike Lütt Luise Ehlers Horst Nizze Robert Jaster | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 2 |
| 2 | Potential and problems of multi-scale segmentation methods in remote sensing显示文摘 | SCHIEWE J TUFTE L EHLERS M | | 0，，01： | 1 |
| 3 | Gender Differences in Electrophysiological Responses to Facial Stimuli 显示文摘 | OROZCO S EHLERS C L | 1998 | Biol Psychiatry1998，44，4： | 1 |
| 4 | Von neumann-morgenstern stable sets in matching problems显示文摘 | Ehlers L | 2007 | Journal of Economic Theory2007，134，1： | 1 |
| 5 | Quality of Care andLength of Hospital Stay among Patients with Stroke显示文摘 | Svendsen M Ehlers L Andersen G | 2009 | Med-ical Care2009，47，5： | 1 |
| 6 | Potential and problems of multi- scale segmentation methods in remote sensing显示文摘 | Scheiewe J Tufte L Ehlers M | 2001 | Geo-BIT/GIS2001，，6： | 1 |
| 7 | RP4 plasmid transfer among species of pseudomonas in a biofilm reactor 显示文摘 | Ehlers L J Bouwer E J | 1999 | Water Sci Technol1999，39，： | 1 |
| 8 | Patient personality and mortality: A 4-year prospective examination of chronic renal insufficiency显示文摘 | Christensen A J Ehlers S L Wiebe J S Moran P J Raichle K Ferneyhough K Lawton W J | 2002 | Health Psychology2002，21，4： | 1 |
| 9 | Heart-beat perception, panic/ somatic symptoms and anxiety sensitivity in children 显示文摘 | Eley TC Stirling L Ehlers A | 2004 | Behav Res Ther2004，42，4： | 1 |
| 10 | Development of an Occluded Gas Ion Source显示文摘 | Ehlers KW Gow JD Ruby L | 1958 | Rev Sci Inst1958，29，7： | 1 |
| 11 | Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle显示文摘 | Nadeau K J Ehlers L B Aguirre L E | 2006 | American Journal of Physiological Endocrinology Metabolism2006，291，1： | 1 |
| 12 | Truncation strategies in matching markets显示文摘 | Ehlers L | 2008 | Mathematics of Operations Research2008，33，2： | 1 |
| 13 | Interaction between functional health literacy and telehomecare: Short-term ef- fects from a randomized triM显示文摘 | Hcesum LKE Ehlers L Hejlesen OK | 2016 | Nurs Health Sei2016，23，3： | 1 |
| 14 | Sharing a River among Satiable Agents 显示文摘 | STEFAN A EHLERS L | 2008 | Games and Economic Behavior2008，64，1： | 1 |
| 15 | Truncation strategies in matching markets显示文摘 | Ehlers L | 2008 | Mathematics of Operations Research2008，33，2： | 1 |
| 16 | RP4 plasmid transfer among species of pseudomonas in a biofilm reactor 显示文摘 | Ehlers L J Bouwer E J | 1999 | Wat Sci Tech1999，39，7： | 1 |
| 17 | Intraguild predation among biological control agents:theory and evidence显示文摘 | Rosenheim J A Kaya H K Ehler L E | 1995 | Biological Control1995，5，： | 1 |
| 18 | Contaminant bioavailability in soil and sedi- ment 显示文摘 | EHLERS L J LUTHY R G | 2003 | Environmental Science & Technology2003，37，15： | 1 |
| 19 | Quality of Care and Length of Hospital Stay Among Patients With Stroke显示文摘 | Svendsen M Ehlers L Andersen G | 2009 | Medical Care2009，47，5： | 1 |
| 20 | Doing mini-health technology assessments in hospitals:A new concept of decision support in health care?显示文摘 | Ehlers L Vestergaard M Kidholm K | 2006 | lnt J Technol Assess Health Care2006，22，3： | 1 |
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