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| 1 | Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli显示文摘Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli(E. coli).Results: The F18 E. coli infection reduced(P < 0.05) growth performance and intestinal villi height, whereas increased(P < 0.05) diarrhea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation(PI)(P < 0.05) and d 0 to 11 PI(P = 0.058). Supplementation of high dose of Bacillus subtilis reduced(P < 0.05) both transcellular and paracellular permeability on d 5 and d11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated(P < 0.05)the m RNA expression of SLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P < 0.05) expression of SLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated(P < 0.05) the m RNA expression of CFTR and ZO1 on d 5 PI and SLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased(P < 0.05) the m RNA expression of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P < 0.05) in ileal mucosa of E. coli infected pigs.Conclusions: Supplementation of Bacillus subtilis(DSM 25841) enhanced growth rate and improved gut barrier function of weaned pigs experimentally infected with a pathogenic E. coli. | Kwangwook Kim Yijie He Xia Xiong Amy Ehrlich Xunde Li Helen Raybould Edward R.Atwill Elizabeth A.Maga Jens JΦrgensen Yanhong Liu | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 2 | Refinement of CARTO-guided substrate modification in patients with ventricular tachycardia after myocardial infarction显示文摘背景:CARTO 系统指导的底层修正被介绍了在心肌的梗塞(MI ) 以后便于心室性心博过速(vt ) 的线性脱离。然而,没有为画这些脱离线可得到的通常接受的标准途径。因此,现在的学习的目的是实际上这次精制消费过程。方法:底层修正用 CARTO 系统在 MI 以后与经常的 vt 在 23 个连续病人被执行。起始的目标地点(它的) 因为脱离被印射的步(下午) 在 vt 期间在室性节律或乘火车踱步(他们) 期间识别。根据起始的目标地点,二条途径被使用。在途径一的起始的目标地点从刺激作为 vt 和间隔有类似的 QRS 形态学到=的 QRS ( S-QRS )的发作 50 ms 在在室性节律或在间隔和 vt 上踱步的柱子的差别的下午期间骑车长度= 30 ms 在隐藏的乘火车期间 vt 踱步;在途径二的起始的目标地点作为 vt 和 <
的 S-QRS 有类似的 QRS 形态学 50 ms 在在室性节律的下午期间。结果:总的来说, 50 根线被执行与一段(35 +/- 11 ) 公里。平均的过程时间(232 +/- 56 ) 分钟,荧光检查时间(10 +/- 8 ) 分钟。十六个病人开始被包含进途径一。在 1 脱离衬里的 3 +/- 的结束以后,没有进一步的 vt 在 13 个病人是可诱导的。留下 3 个病人被换到选择接近的使用。然而,在没有,他们,其他的途径是成功的。途径二开始在 7 个病人被使用。在 1 脱离衬里的 3 +/- 的结束以后,没有进一步的 vt 在仅仅 2 个病人是可诱导的。留下 5 个病人被换到接近一个,它在他们中的 4 个导致了 vt 的 noninducibility。起始的成功的率在途径二的组在与那相比的途径一的组是显著地更高的(13/16 病人对 2/7 病人, P 0.026 ) 。结论:为在 MI 以后的 vt 的底层修正的途径能被在慢传导的地区以内与特定的特征识别适当起始的目标地点优化。精制途径可以便于 vt 的线性脱离,并且进一步减少过程和荧光检查时间。 | LI Yi-gang WANG Qun-shan Gerian Gronefeld Carsten Israel LU Shang-biao SHAO Yun Joachim R. Ehrlich Stefan H. Hohnloser | 2008 | Chinese Medical Journal2008，，2： | 2 |
| 3 | Comprehensive methylome map of lineage commitment from haematopoietic progenitors 显示文摘 | Ji H Ehrlich LI Seita J | 2010 | Nature2010，467，7313： | 1 |
| 4 | The contribution of chemokines and migration to the induction of central tolerance in the thymus显示文摘 | Hu Z Lancaster JN Ehrlich LI | 2015 | Front Immunol2015，6，： | 1 |
| 5 | Comprehensive methylome map oflineage commitment from haematopoieticprogenitors显示文摘 | Ji H Ehrlich LI Seita J | 2010 | Nature2010，467，7313： | 1 |
| 6 | Long-term risk of recurrent atrial fibrillation as documented by an implantable monitoring device. Implications for optimal patient care显示文摘 | C.W. Israel G. Gronefeld J.R. Ehrlich Y.G. Li S.H. Hohnloser | 2004 | ACC Current Journal Review2004，，4： | 1 |
| 7 | Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells显示文摘 | Ehrlich LI Ogasawara K Hamerman JA | 2005 | J lmmlnol2005，174，： | 1 |
| 8 | HypC, the anthrone oxidase involved in aflatoxin biosynthesis显示文摘 | Ehrlich KC Li P Scharfenstein L | 2010 | Applied and Environmental Microbiology2010，76，： | 1 |
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