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| 1 | Functional Analysis of Slow Myosin Heavy Chain 1 and Myomesin-3 in Sarcomere Organization in Zebrafish Embryonic Slow Muscles显示文摘Myofibrillogenesis, sarcomere 形成的过程,要求 sarcomeric 蛋白质的靠近的相互作用和 sarcomere 结构的各种各样的部件。肌浆球蛋白厚细丝和 M 线是 sarcomere 的二个关键部件。M 线的 myomesin 蛋白质与肌浆球蛋白和 titin 蛋白质交往并且使,这被建议了厚并且有序的 titin 细丝。然而,在 myofibrillogenesis 和 sarcomere 组织的 myomesin 的功能仍然保持大部分神秘。没有猛烈或击倒的动物模型被报导了阐明在 sarcomere 组织 in vivo 的 myomesin 的角色。在这研究,由在 zebrafish 胚胎使用基因特定的击倒的途径,我们执行了 myomesin-3 和慢肌浆球蛋白的 loss-of-function 分析重链(smyhc1 ) 1 在慢肌肉明确地表示了。我们表明了那废除的 smyhc1 击倒在慢肌肉的 myomesin-3 的 sarcomeric 本地化。相反, myomesin-3 的损失没在厚、薄的细丝以及 M 线和 Z 线结构的 sarcomeric 组织上有效果。一起,这些研究显示那肌浆球蛋白厚细丝为 M 线组织和 myomesin-3 的 M 线本地化被要求。相反, myomesin-3 为在慢肌肉的 sarcomere 组织是非必需的。 | Jin Xu Jie Gao Junling Li Liangyi Xue Kan J. Clark Stephen C. Ekker Shao Jun Du | 2012 | Journal of Genetics and Genomics2012，39，2： | 6 |
| 2 | A nuncnnatelhte genetic linkage map for the Zebrafish显示文摘 | Knspik E W Goodman A Ekker M | 1998 | Genes Dev1998，18，： | 1 |
| 3 | A microsatellite genetic linkage map for zebrafish(Danio rerio)显示文摘 | Knapik E W Goodman A Ekker M | 1998 | Nature Genetics1998，18，： | 1 |
| 4 | Trapping fish genes with transposons 显示文摘 | Balciunas D Ekker SC | 2005 | Zebrafish2005，1，4： | 1 |
| 5 | Hedgehog patterning activity : role of a lipophilic modification mediated by the carboxyterminal autoprocessing domain显示文摘 | Porter JA Ekker SC Park WJ | 1996 | Cell1996，86，1： | 1 |
| 6 | Coordinate embryonic expression of three zebrafish engrailed genes 显示文摘 | Ekker M Wegner J Akimenko M A | 1992 | Development1992，116，4： | 1 |
| 7 | Autoproteolysis in hedgehog protein biogenesis 显示文摘 | Lee J J Ekker SC von Kessler DP | 1994 | Science1994，266，5190： | 1 |
| 8 | A microsatellite genetic linkage nap for zebrafish( Danio rerio) 显示文摘 | KNAPIK EW GOODMAN A EKKER M | 1998 | Genet1998，18，4： | 1 |
| 9 | The product of hedgehog autoproteolytic cleavage active in local and long-range signalling 显示文摘 | Porter JA von Kessler DP Ekker SC | 1995 | Nature1995，374，6520： | 1 |
| 10 | Review: The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foods 显示文摘 | Mithen R F D ekker M Verk erk R | 2000 | Journal of the science of food and agriculture2000，80，： | 1 |
| 11 | Patterning activities of vertebrate hedgehog proteins in the developing eye and brain显示文摘 | Ekker SC Ungar AR Greenstein P | 1995 | Curr Biol1995，5，8： | 1 |
| 12 | Teleost PTZ-F1 homolog and its splicing variant determine the expression of the salmon gonadotropin II 8subunit gene显示文摘 | Liu D Le Drean Y Ekker M | 1997 | Mol Endocrinol1997，11，7： | 1 |
| 13 | Teleost FTZ-F1 homo-log and its splicing variantdetermine the expression of the salmon gonadotropin Ⅱ8 subunit gene显示文摘 | Liu D Le Drean Y Ekker M | 1997 | Mol Endocrinol1997，11，7： | 1 |
| 14 | Effective targeted gene'knockdown'in zebrafish显示文摘 | Nasevicius A Ekker S C | 2000 | Nature Genetics2000，26，： | 1 |
| 15 | Teleost FTZ-F1 homolog and its splicing variant determine the expression of the salmon gonadotropin Ⅱ beta subunit gene 显示文摘 | liu d le drean y ekker m | 1997 | Molecular Endocrinology1997，11，7： | 1 |
| 16 | Syndecan - 2 is essential for an- giogenic sprouting during zebralish development 显示文摘 | Chen E Hermanson S and Ekker SC | 2004 | Blood2004，103，5： | 1 |
| 17 | ,Performance of clinical signs to detect bluetongue virus serotype 8 outbreaks in-cattle and sheep during the 2006 - epidemic in The Netherlands 显示文摘 | ELBERS A R BACKX A EKKER H M | 2008 | Vet Microbiol2008，129，12： | 1 |
| 18 | Retrograde interlocking nailing of distal femoral fractures with the intramedullary supracondylar nail 显示文摘 | Ostermann PA Hahn MP Ekker A | 1996 | Chirurg1996，67，11： | 1 |
| 19 | Anterior duplication of the Sonic hedgehog expression pattern in the pectoral fin buds of zebrafish treated with retinoic acid显示文摘 | Akimenko MA Ekker M | 1995 | Dev Biol1995，170，1： | 1 |
| 20 | Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain显示文摘 | Porter J A Ekker S C Park W J | 1996 | Cell1996，86，1： | 1 |
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