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| 1 | Vascular calcification:When should we interfere in chronic kidney disease patients and how?显示文摘Chronic kidney disease(CKD) patients are endangered with the highest mortality rate compared to other chronic diseases. Cardiovascular events account for up to 60% of the fatalities. Cardiovascular calcifications affect most of the CKD patients. Most of this calcification is related to disturbed renal phosphate handling. Fibroblast growth factor 23 and klotho deficiency were incriminated in the pathogenesis of vascular calcification through different mechanisms including their effects on endothelium and arterial wall smooth muscle cells. In addition, deficient klotho gene expression, a constant feature of CKD, promotes vascular pathology and shares in progression of the CKD. The role of gut in the etio-pathogenesis of systemic inflammation and vascular calcification is a newly discovered mechanism. This review will cover the medical history, prevalence, pathogenesis, clinical relevance, different tools used to diagnose, the ideal timing to prevent or to withhold the progression of vascular calcification and the different medications and medical procedures that can help to prolong the survival of CKD patients. | Usama Abdel Azim Sharaf El Din Mona Mansour Salem Dina Ossama Abdulazim | 2016 | World Journal of Nephrology2016，5，5： | 10 |
| 2 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 3 | Hepatitis C virus:A global view显示文摘Hepatitis C virus(HCV) is a global challenge; 130-175 million are chronically infected. Over 350000 die each year from HCV. Chronic HCV is the primary cause of cirrhosis, hepatocellular carcinoma(HCC), and end-stage liver disease. Management of chronic HCV is aimed at preventing cirrhosis, reducing the risk of HCC, and treating extra hepatic complications. New treatments for chronic HCV has been devoted based on direct-acting antivirals, as pegylated interferon(peginterferon) is responsible for many side effects and limits treatment access. Sofosbuvir is the first compound to enter the market with Peginterferon-free combination regimens. | Amal Ahmed Mohamed Tamer A Elbedewy Magdy El-Serafy Naglaa El-Toukhy Wesam Ahmed Zaniab Ali El Din | 2015 | World Journal of Hepatology2015，7，26： | 7 |
| 4 | Stop chronic kidney disease progression: Time is approaching显示文摘Progression of chronic kidney disease(CKD) is inevitable. However, the last decade has witnessed tremendous achievements in this field. Today we are optimistic; the dream of withholding this progression is about to be realistic. The recent discoveries in the field of CKD management involved most of the individual diseases leading the patients to end-stage renal disease. Most of these advances involved patients suffering diabetic kidney disease, chronic glomerulonephritis, polycystic kidney disease, renal amyloidosis and chronic tubulointerstitial disease. The chronic systemic inflammatory status and increased oxidative stress were also investigated. This inflammatory status influences the antisenescence Klotho gene expression. The role of Klotho in CKD progression together with its therapeutic value are explored. The role of gut as a major source of inflammation, the pathogenesis of intestinal mucosal barrier damage, the role of intestinal alkaline phosphatase and the dietary and therapeutic implications add a novel therapeutic tool to delay CKD progression. | Usama Abdel Azim Sharaf El Din Mona Mansour Salem Dina Ossama Abdulazim | 2016 | World Journal of Nephrology2016，5，3： | 6 |
| 5 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 6 | HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro显示文摘瞄准:与丙肝的长期的复制建立一个房间文化系统病毒(HCV ) 染色体和病毒的抗原的表示在试管内。方法:HepG2 房间线被孵化与长期的丙肝从一个病人与浆液为它的危险性测试到 HCV。房间和上层清液在文化期间在各种各样的时间点被收获。文化上层清液为它感染天真的房间的能力被测试。存在减(反感觉) 在房间的核心和 E1 抗原的 RNA 海滨,和察觉被 RT-PCR 和免疫学的技术(流动血细胞计数和西方的污点) 分别地检验。结果:细胞内部的 HCV RNA 首先在 d 上被检测 3 在感染以后然后能一致地在至少三个月的一个时期上在房间和上层清液被检测。新鲜房间能从有教养的感染的房间感染上层清液。流动 cytometric 分析证明表面和在房子里使用的细胞内部的 HCV 抗原表示使 polyclonal 成为了抗体(反核心,和 anti-E1 ) 。西方的污点分析证明在分子量的产生免疫性的肽的簇的表示在一个月内在 31 和 45 kDa 之间延长了感染的房间的旧文化而这簇在 uninfected HepG2 房间是无法发现的。结论:HepG2 房间线产生 HCV 感染而且支持它的复制在试管内不仅。HCV 结构的蛋白质的表示能在感染的 HepG2 房间被检测。这些房间也能够流病毒的粒子进接着对 uninfected 房间变得传染的培养基。 | Mostafa K El-Awady Ashraf A Tabll Yasmine S El-Abd Mahmoud M Bahgat Hussein A Shoeb Samar S Youssef Noha G Bader El Din El-Rashdy M Redwan Maha El-Demellawy Moataza H Omran Wael T El-Garf Said A Goueli | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 7 | An Electrochemical and Esca Study on the Tarnishing of Silver in Solutions of Different pS and pH Values显示文摘 | DIN A M Shams El KADER J M Abd El WAHAB F M Abd El | 1985 | Electrochimica Acta1985，30，4： | 1 |
| 8 | Investigation of a high temperature organic water shut- off gel: reaction mechanisms显示文摘 | AL-MUNTASHERI G A NASR EL DIN H A PETERS J | 2006 | SPE Journal2006，11，49： | 1 |
| 9 | Lactococ- cus lactis - expressing listeriolysin O ( LLO ) provides protection and specific CD8 ( + ) T cells against Listeria monocytogenes in the murine infection model显示文摘 | BAHEY EL DIN M CASEY P G GRIFFIN B T | 2008 | Vaccine2008，26，41： | 1 |
| 10 | Serum nerve growth factor levels in autistic children in Turkish population:apreliminary study显示文摘 | Dinel N nalp A Kutlu A | 2013 | Indian J Med Res2013，138，6： | 1 |
| 11 | Pharmacokinetic modelling of valproic acid from routine clinical data in Egyptian epileptic patients显示文摘 | Fuseau E EL Din Amry S Cosson V | 2004 | Eur J Clin Pharmacol2004，59，： | 1 |
| 12 | Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody显示文摘 | Grewal HP Mohey EL Din A | 1994 | Am J Surg1994，167，1： | 1 |
| 13 | IR spectroscopic study on the thermal degradation of plastic security cover sheets of some documents显示文摘 | El - Din N M | 1993 | Journal of Applied Polymer Science1993，47，5： | 1 |
| 14 | Establishment of human clones producing neutralizing humanmonoclonal antibodies to the envelope E1/E2 protein of hepatitis C virus by EBVimmortalization of immune CD22+ B cells显示文摘 | Ashraf Tabll Yasmine El Abd Noha G. Bader El Din Reem El Shenawy Tawfeek H. Abdelhafez Mostafa El Awady Hanan El-Mohamady Sergei Viazov | | 2014 (3,4)0，，： | 1 |
| 15 | Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-α polyclonal antibody显示文摘 | Grewal HP Mohey el Din A Gaber L | 1994 | Am J Surg1994，167，1： | 1 |
| 16 | Correlation between uroflowmetry,postvoided residual, and lower urinary tract symptoms as measured by the International Prostate Symptom Score 显示文摘 | El Din KE Kiemeney LALM De Wildt MJAM Rosier PFWM Debruyne FMJ de la Rosette JJMCH | 1996 | Urology1996，48，： | 1 |
| 17 | The correlation between bladder outlet obstruction and lower urinary tract symptoms as measured by the International Prostate Symptom Score显示文摘 | El Din KE Kiemeney LALM De Wildt MJAM Rosier PFWM Debruyne FMJ de la Rosette JJMCH | 1996 | J Urol1996，156，： | 1 |
| 18 | Mechanism of corrosion inhibition by sodium molybdate 显示文摘 | SHAMS EL DIN A M WANG L F | 1996 | Desalination1996，，： | 1 |
| 19 | MOUSE MONOCLONAL ANTIBODY TOWARDS E1 SPECIFIC EPITOPE BLOCKS VIRAL ENTRY AND INTRACELLULAR VIRAL REPLICATION IN VITRO显示文摘 | AshrafA. Tabll RehabI. Moustafa YasmineS. El Abd NohaG. Bader El Din Reem El-Shenawy Hassan Yousef Manal Hussein RehamM. Dawood MoatazaH. Omran MostafaK. El-Awady | 2014 | Journal of Immunoassay and Immunochemistry2014，，1： | 1 |
| 20 | Water-soluble hydrophobi- tally associating polymers for improved oil recovery: A literature review显示文摘 | Taylor K C Nasr El Din H A | 1995 | Journal of Petroleum Science En- gineering1995，28，19： | 1 |
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