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| 1 | Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial显示文摘AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins(CEP) in Crohn's disease (CD) subjects.METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels.RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CDS+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period.CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation. | Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 2 | 化学气相反应法制备Zr-Si-C涂层显示文摘为了提高Zr-Si-C涂层与基体的结合强度,基于粉末埋入反应辅助涂覆工艺,采用新型化学气相反应法在SiC陶瓷表面制备Zr-Si-C涂层。SiC陶瓷基片被包埋于Zr-1%(质量分数)I_2混合粉体中,在850~1100℃进行化学气相反应。碘促进Zr原子向SiC陶瓷表面的传输,Zr与SiC之间的扩散反应导致在SiC表面生成连续的Zr-Si-C复合涂层。采用X射线衍射、扫描电镜结合X射线能谱分析以及相图分析确定了涂层微结构及相组成。结果表明:复合涂层内层为ZrC、中间层为Zr_2Si-ZrC_(1-x)复相区、外层为ZrC_(1-x)。通过测量涂层厚度研究了涂层的生长动力学.在850~1100℃范围内,涂层生长符合抛物线规律,活化能为(210±20)kJ/mol。 | 殷小玮 GUTMANAS Elazar 成来飞 张立同 | 2007 | 硅酸盐学报2007，35，11： | 7 |
| 3 | Influence of 1-Methylcyclopropene (1-MCP) on Postharvest Storage Quality in Green Bell Pepper Fruit显示文摘 | Zoran S. Ili? Radmila Trajkovi? Yaacov Perzelan Sharon Alkalai-Tuvia Elazar Fallik | 2012 | Food and Bioprocess Technology2012，，7： | 2 |
| 4 | Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis显示文摘 | Simon Yona Ki-Wook Kim Yochai Wolf Alexander Mildner Diana Varol Michal Breker Dalit Strauss-Ayali Sergey Viukov Martin Guilliams Alexander Misharin David A. Hume Harris Perlman Bernard Malissen Elazar Zelzer Steffen Jung | 2013 | Immunity2013，，5： | 2 |
| 5 | Regulation of autophagy by ROS: physiology and pathology显示文摘 | Ruth Scherz-Shouval Zvulun Elazar | 2010 | Trends in Biochemical Sciences2010，，1： | 2 |
| 6 | Autophagy-independent incorporation of GFP-LC3 into protein aggregates is dependent on its interaction with p62/SQSTM1显示文摘 | Shvets E Elazar Z | 2008 | Autophagy2008，4，8： | 1 |
| 7 | Regulation of autophagy by ROS : physiology and pathology 显示文摘 | Scherz - Shouval R Elazar Z | 2011 | Trends Biochem Sci2011，36，1： | 1 |
| 8 | Regulation of autophagy by ROS physiology and pathology显示文摘 | Scherz-Shouval R Elazar Z | 2011 | Trends Biochem Sci2011，36，1： | 1 |
| 9 | ROS, mitochondria and the regulation of autophagy 显示文摘 | Scherz-Shouval R Elazar Z | 2007 | Trends Cell Biol2007，17，9： | 1 |
| 10 | Elevated temperature stability of powder processed Al-Fe-Ni 显示文摘 | Gutmanas Elazar Y Botstein | 2000 | International Journal of Powder Metallurgy2000，36，2： | 1 |
| 11 | Regulation ofautophagy by ROS : physiology and pathol-ogy 显示文摘 | Scherz-Shouval R Elazar Z | 2011 | Trends Biochem Sci2011，36，1： | 1 |
| 12 | The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes显示文摘 | Shvets E Fass E Scherz-Shouval R Elazar Z | | 0，，16： | 1 |
| 13 | Construct validity of a geriatric version of the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) battery显示文摘 | Katz N Elazar B Itzkovich M | 1995 | Phys Occup Ther Geriatrics1995，13，3： | 1 |
| 14 | Fiber-optic Displacement Sensor显示文摘 | ZIVANOVIC S ELAZAR J TOMIC M | 1997 | IEEE International Conference on Microelectronics1997，，2： | 1 |
| 15 | The atg8 family : Muhifunction- al uhiquitin-like key regulators of autophagy显示文摘 | Slobodkin M R Elazar Z | 2013 | Essays in Biochemistry2013，55，： | 1 |
| 16 | Prestorage hot water treatments (immersion, rinsing and brushing)显示文摘 | Elazar Fallik | 2003 | Postharvest Biology and Technology2003，，： | 1 |
| 17 | Densification of Nanocrystalline MgO Ceramics by Hot-pressing显示文摘 | David E Elazar Y G Rachman C | 2005 | Journal of the European Ceramic Society2005，25，： | 1 |
| 18 | ROS, mitochondria and the regulation of autophagy显示文摘 | Scherz-Shouval R Elazar Z | 2007 | Trends Cell Biol2007，17，9： | 1 |
| 19 | ROS,mitochondria and the regulation of autophagy显示文摘 | Scherz-Shouval R Elazar Z | 2007 | Trends Cell Biol2007，17，1： | 1 |
| 20 | Tendon - to - bone attach- merit: from development to maturity 显示文摘 | Elazar Zelzer Einat Blitz Megan L | 2014 | Birth Defects Res C Embryo Today2014，3102，1： | 1 |
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