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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Classi- fication of Brazilian honeys by physical and chemical analyti- cal methods and low field nuclear magnetic resonance (LFIH NMR) 显示文摘 | Roberta de O R R Eliane T M Carla da S C | 2014 | LWT- Food Science and Technology2014，55，： | 1 |
| 3 | Fatigue life estimates for a slender orthotropic steel deck 显示文摘 | Ronaldo C Battista Michele S Pfeil Eliane M L Carvalho | 2008 | Journal of Constructional Steel Research2008，64，： | 1 |
| 4 | Actinic prurigo of the lip: Two case reports显示文摘Actinic prurigo is a photodermatosis that can affect the skin, conjunctiva and lips. It is caused by an abnormal reaction to sunlight and is more common in high-altitude living people, mainly in indigenous descendants. The diagnosis of actinic prurigo can be challenging, mainly when lip lesions are the only manifestation, which is not a common clinical presentation. The aim of this article is to report two cases of actinic prurigo showing only lip lesions. The patients were Afro-American and were unaware of possible Indian ancestry. Clinical exam, photographs, videoroscopy examination and biopsy were performed, and the diagnosis of actinic prurigo was established. Topical corticosteroid and lip balm with ultraviolet protection were prescribed with excellent results. The relevance of this report is to show that although some patients may not demonstrate the classical clinical presentation of actinic prurigo, the associated clinical and histological exams are determinants for the correct diagnosis and successful treatment of this disease. | Ana MO Miranda Thiago M Ferrari Juliana T Werneck Arley Silva Junior Karin S Cunha Eliane P Dias | 2014 | World Journal of Clinical Cases2014，2，8： | 1 |
| 5 | Effect of interimplant dis-tance (2 and 3 mm)on the height of interimplant bone crest:a histomorphometric evaluation 显示文摘 | Elian N Bloom M Dard M | 2011 | J Periodontol2011，82，12： | 1 |
| 6 | Effect of interimplant distance (2 and 3 mm) on the height of interimplant bone crest: a histomor- phometric evaluation 显示文摘 | Elian N Bloom M Dard M | 2011 | J Periodontol2011，82，12： | 1 |
| 7 | Effect of interimplant distance (2and 3 mm)on the height of interimplant bone crest: a histomor-phometric evaluation 显示文摘 | Elian N Bloom M Dard M | 2011 | J Periodontol2011，82，12： | 1 |
| 8 | Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with mycobacterium tuberculosis显示文摘 | Demissie A Eliane M S Leyten | 2006 | Clin Vaccine Immunol2006，13，2： | 1 |
| 9 | Antimicrobial susceptibility pattern and plasmid profile in Salmonella Muenster isolated from wine and abattoir environment, Brazil显示文摘 | Norma S L Anita T Eliane M F | 2004 | Pesquisa Veteri- naria Brasileira2004，24，2： | 1 |
| 10 | Specific T-Cell Epitopes for Immunoassay-Based Diagnosis of Mycobacterium tuberculosis Infection显示文摘 | Inger Brock Karin Weldingh Eliane M S Leyten | 2004 | Journal of Clinical Microbiology2004，42，： | 1 |
| 11 | Monitoring serial changes in circulating human breast cancer cells in murine xenograft models 显示文摘 | Eliane JP Repollet M Luker KE | 2008 | Cancer Res2008，68，14： | 1 |
| 12 | Mobilization and r-ecovery of energy stores in trai′ra,Hoplias malabaricus bloch(Teleostei,Erythrinidae)during long-term starvation and after re-feeding显示文摘 | Flavia S R Gilberto M Eliane T O | 2006 | Comp Physiol B2006，176，： | 1 |
| 13 | A survey for the quadratic assignment problem显示文摘 | ELIANE M L NAIR M M PAULO O B N | | 0，，02： | 1 |
| 14 | Carvalhob fatigue life estimates for a slender orthotropic steel deck显示文摘 | Battista R C Pfeila M S Eliane M L | | 0，，64： | 1 |
| 15 | Validation of an HPLC Methodology for the Identification and Quantification of Biogenic Amines in Chicken Meat显示文摘 | César A. Lázaro Carlos A. Conte-Júnior Fernanda L. Cunha Eliane T. Mársico Sérgio B. Mano Robson M. Franco | 2013 | Food Analytical Methods2013，，4： | 1 |
| 16 | Mutation in Wnt10A is associated with an autosomal recessive ectodermal dysplasia:The odonto-onycho-dermal dysplasia 显示文摘 | LYNN A ELIANE C HALA M B | 2007 | Am J Hum Genet2007，81，4： | 1 |
| 17 | Hormo-nal and metabolic adaptations to fasting in monosodiumglutamate-obese rats 显示文摘 | Eliane B R Claudia M O Irecema S A | 1997 | J Comp Physiol B1997，167，43： | 1 |
| 18 | Interaction of Gadoliniumbased MR contrast agents with choline:implications for MR spectroscopy (MRS) of the breast显示文摘 | Lenkinski RE Wang X Elian M | 2009 | Magn Reson Med2009，61，： | 1 |
| 19 | Multiple sclerosis among United Kingdom-born children of immigrants from the Indian subcontinent,Africa and the West Indies显示文摘 | Elian M Nightiqale S Dean G | 1990 | J Neurol Neurosueq Psychiatry1990，53，10： | 1 |
| 20 | Motor neuron disease and multiple sclerosis among immigrants to England from the Indian subcontinent, the Caribbean, and east and west Africa 显示文摘 | Elian M Dean G | 1993 | J Neurol Neurosurg Psychiatry1993，56，5： | 1 |
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