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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Effects of flow cytometry analysis on morphology and viability of fragile phytoplankton显示文摘 | ELIN M H TERRY L C CLARICE M Y | 1987 | Applied and Environmental Microbiology1987，53，11： | 1 |
| 3 | Endotox- emia in human septic shock显示文摘 | Danner R L Elin R J Hosseini J M | 1991 | Chest1991，99，1： | 1 |
| 4 | Differential Toxicity and Environmental Fates of Hexachlorocyclohexane Isomers 显示文摘 | Kristine L Willett Elin M Ulrich Ronald A Hites | 1998 | Environ Sci Technol1998，32，： | 1 |
| 5 | Light chain proteinuria and lysozymuria in a patient with acute monocytic leukemia显示文摘 | Levinson S S Elin R J Yam L | 2002 | Clin Chem2002，48，： | 1 |
| 6 | Light Chain Proteinuria and Lysozymuria in a Patient with Acute Monocytic Leukemia显示文摘 | Levinson S S Elin R J Yam L | 2002 | Clin Chem2002，48，： | 1 |
| 7 | Physical training increases heart rate variability in healthy pre- pubertal children显示文摘 | M andigot S M elin A Fauchier L | 2002 | Eur J Clin Invest2002，32，7： | 1 |
| 8 | Different toxicity and environmental fates of hexachlorocyclohexane isomers显示文摘 | Keistine L W Elin M U Ronald A H | 1998 | Environmental Science & Technology1998，32，： | 1 |
| 9 | Environmental control of schistosomiasis through community participation in a Moroccan oasis显示文摘 | Eline B Hammou L | 2004 | Trop Med Int Hlth2004，9，9： | 1 |
| 10 | Differen- tial toxicity and environmental fates of hexachlorocyclohex- ane isomers显示文摘 | Willett Kristine L Ulrich Elin M Hites Ronald A | 1998 | Environmental Science and Technology1998，32，15： | 1 |
| 11 | Glucose and insulin responses in healthy man to barley bread with different levels of ( 1 - 3 ; 1 - 4)- β-glucan, : predictions using fluidity measurements of in vitro enzyme digests 显示文摘 | Elin O Emanuele R Helena L | 2006 | Journal of Cereal Science2006，43，： | 1 |
| 12 | Blood magnesium status of patients with parathyroid disease显示文摘 | ELIN R J HOSSEINI JM FITZPATRICK L | 1990 | Magnes Trace Elem1990，9，3： | 1 |
| 13 | Differential toxicity and environmental fates of hexachlorocyclohexane isomers显示文摘 | Kristine L W Elin M U Ronald A H | 1998 | Environ Sci Technol1998，32，： | 1 |
| 14 | Application of diamondoids to distinguish source rock facies显示文摘 | Schulz L K Arnd W Elin R | 2001 | Organic Geochemistry2001，32，3： | 1 |
| 15 | Differential toxicity and environmental fates of hexachlorocyclohexane isomers 显示文摘 | Kristine L W Elin M U Hites R A | 1998 | Environmental Science and Technology1998，32，15： | 1 |
| 16 | Quantity and qualily of sleep and incidence of type 2 diabetes:a systematic review and meta - analysis显示文摘 | Cappuccio FP D'Elin L Strazzullo P | 2010 | Diabetes Care2010，33，： | 1 |
| 17 | Application of diamondoids to distinguish source rock facies 显示文摘 | Schulz L K Amd W Elin R | 2001 | Organic Geochemistry2001，32，3： | 1 |
| 18 | Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease 显示文摘 | Deanna M Elin L Chu YP | 2007 | Brain Res2007，1147，： | 1 |
| 19 | Differential toxicity and environmental fates of hexachlorocyclohexane isomers显示文摘 | Kristine L W Elin M U Hites R A | 1998 | Environ Sci Technol1998，32，15： | 1 |
| 20 | Carbon isotope signature variability among cultured microalgae: Influence of species, nutrients and growth 显示文摘 | Andreas B Elin L Edna G | 2009 | Journal of Experimental Marine Biology and Ecology2009，372，： | 1 |
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