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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Crucial role of stromal cell-derived factor-1α in neointima formation after vascular injury in apolipoprotein e-deficient mice显示文摘 | Andreas S Sandra K Michael L Elisa AL Christian W | 2003 | Circulation2003，108，： | 1 |
| 3 | Guidelines to cell engineering for monoclonal anti- body pro-duction显示文摘 | RAta Costa A Elisa Kodrigues M Henriques M et al | 2010 | EurJ Pharm Biopharm2010，74，2： | 1 |
| 4 | Expression of Pleurotus eryngii aryl-alcohol oxidase in Aspergillus nidulans: puri￠ cation and characterization of the recombinant enzyme 显示文摘 | Elisa Varela Francisco Guillen et al | 2001 | Biochimica et Biophysica Acta2001，，1546： | 1 |
| 5 | Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by p-selectin and chemokines显示文摘 | Ute Z Andreas S Michael L Elisa AL Wolfgang E Neil E | 2004 | Circ Res2004，94，： | 1 |
| 6 | Apoptosis and emphysema:the missing link显示文摘 | Tuder RM Petrache I Elisa JAe t al | 2003 | Am J Cell Mol Biol2003，28，： | 1 |
| 7 | Assessing tourist behavioral intentions through perceived service quality and customer satisfaction显示文摘 | Alén González María Elisa Comesa(n)a Lorenzo Rodríguez Fraiz Brea José Antonio | | 0，，： | 1 |
| 8 | Competing for the disability tourism market – A comparative exploration of the factors of accessible tourism competitiveness in Spain and Australia显示文摘 | Trinidad Domínguez Vila Simon Darcy Elisa Alén González | 2015 | Tourism Management2015，，： | 1 |
| 9 | The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study显示文摘 | Elisa De Franco Sarah E Flanagan Jayne AL Houghton Hana Lango Allen Deborah JG Mackay I Karen Temple Sian Ellard Andrew T Hattersley | 2015 | The Lancet . 2015 (9997)2015，，9997： | 1 |
| 10 | Answering XML queries by means of data summaries显示文摘 | Elcna Baralis Paolo Garza Elisa QuintarcUi ct al | 2007 | ACM Transactions on Information Systems2007，25，3： | 1 |
| 11 | Crucial role of stromal cell-derived factor-1α in neointima formation after vascular injury in apolipoprotein E-deficient mice显示文摘 | Andreas S Sandra K Micheal L Elisa AL Christian W | 2003 | Circ2003，108，： | 1 |
| 12 | pharmacogenomics of gemcitabine in non-small-cell lung cancer and other solid tumors显示文摘 | Romano D Giuseppe AL Elisa G | 2009 | Pharmacogenomics2009，10，1： | 1 |
| 13 | Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by P-selectin and chemokines显示文摘 | Ute Z Andreas S Michael L Elisa AL Wolfgang E Neil E | 2004 | Circ Res2004，94，： | 1 |
| 14 | Crucial role of stromal cell-derived factor-1α in neointima formation after vascular injury in apolipoprotein E-deficient mice显示文摘 | Andreas S Sandra K Micheal L Elisa AL Christian W | 2003 | Circulation2003，108，： | 1 |
| 15 | Chinese Physicians and their Smoking Knowledge, Attitudes, and Practices显示文摘 | Yuan Jiang Michael K Elisa K el al | 2007 | American Journal of Preventive Medicine2007，33，1： | 1 |
| 16 | Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by P-selectin and chemokines显示文摘 | Ute Z Andreas S Michael L Elisa AL Wolfgang E Neil E | 2004 | Circ Res2004，94，： | 1 |
| 17 | Characterization of the molecular dysfunctions occurring in Aicardi-Goutieres syndrome patients with mutations in ADAR1显示文摘Aicardi-Goutieres syndrome(AGS)is a systemic inflammatory disorder caused by mutations in any one of the nine different genes,whose deficiency provokes a type I(interferon)IFN response probably central to pathogenesis.^(1) ADAR1,one of the genes mutated in AGS(AGS6),encodes for an enzyme that belongs to the ADAR family(ADAR1,ADAR2,and ADAR3)that catalyzes the conversion of adenosine to inosine within double-stranded RNAs(dsRNAs)(RNA editing A-to-1). | Sofan Al wardat Loredana Frasinlli Elisa Orecchini Federica Rey Silvia Anna Ciafre Silvia Galardi Jessica Garau Stella Gagliardi Simona Orcesi Davide Tonduti Stephana Carelli Cristina Cereda Ernesto Picardi Alessandro Michienzi | 2024 | Genes & Diseases2024，11，3： | 0 |
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