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| 1 | G protein-coupled receptors: structure- and function-based drug discovery显示文摘As one of the most successful therapeutic target families,G protein-coupled receptors(GPCRs)have experienced a transformation from random ligand screening to knowledge-driven drug design.We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace.This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery. | Dehua Yang Qingtong Zhou Viktorija Labroska Shanshan Qin Sanaz Darbalaei Yiran Wu Elita Yuliantie Linshan Xie Houchao Tao Jianjun Cheng Qing Liu Suwen Zhao Wenqing Shui Yi Jjiang Ming-Wei Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 2 | High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway显示文摘Interferons(IFNs) are cytokines with fundamental roles in resistance to infections, cancer and other diseases. Type-I IFNs, interferon α(IFN-α) and interferon β(IFN-β), act through a shared receptor complex(IFNAR) comprised of IFNAR1 and IFNAR2 subunits. Binding of type-I IFN to IFNAR1 will robustly activate Janus activated kinase-signal transducer and activator of transcription(JAK-STAT)signaling pathway. Aberrant activation of the type-I IFN response results in a spectrum of disorders called interferonopathies. The purpose of this research is to develop an assay for high-throughput screening(HTS) of small molecule inhibitors of the type-I IFN signaling pathway. Inhibition of type-I IFN signaling can be beneficial in terms of therapeutic use and understanding the underlying mechanism of action. We report here a HTS campaign with the secreted embryonic alkaline phosphatase(SEAP) reporter gene assay against 32,000 compounds which yielded 25 confirmed hits. These compounds were subsequently characterized for their cytotoxicity, effects on STAT phosphorylation and activities in IFN regulatory factor(IRF) transcription. | Elita Yuliantie Xinchuan Dai Dehua Yang Peter J.Crack Ming-Wei Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 2 |
| 3 | Measles virus interacts with and alters signal transduction in T-cell lipid rafts显示文摘 | Elita Avota Muller N Klett M | 2004 | J Virol2004，78，17： | 1 |
| 4 | Key performance indicators for sustainable manufacturing evaluation in cement industry显示文摘 | Elita Amrina Annike Lutfia Vilsi | 2015 | Procedia CIRP2015，26，： | 1 |
| 5 | Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil显示文摘 | Fernanda G. Braga Maria Lúcia M. Bouzada Rodrigo L. Fabri Magnum de O. Matos Francis O. Moreira Elita Scio Elaine S. Coimbra | 2006 | Journal of Ethnopharmacology2006，，2： | 1 |
| 6 | HepG2 human hepatoma ceils express multiple cytokine genes显示文摘 | ILMARS S ELITA S STEFAN R | 1999 | Cytokine1999，11，2： | 1 |
| 7 | HepG2 human hepatoma cells express multiple cytokine genes 显示文摘 | Ilmars Stonans Elita Stonane Stefan Ruβwurm | 1999 | Cytokine1999，11，2： | 1 |
| 8 | Sliding modes in constrained systems control显示文摘 | Asif Sabanovic Meltem Elitas Kouhei Ohnishi | 2008 | IEEE Trans on Industrial Electronics2008，55，9： | 1 |
| 9 | Lignan glycosides from inner bark of Betula pendula显示文摘 | ELITA SMITE HEFENG PAN LUNDGREN L N | 1995 | Phytochemistry1995，40，1： | 1 |
| 10 | Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro显示文摘 | Mathias Oberhoffer Ilmārs Stonāns Stefan Russwurm Elita Stonāne Heinz Vogelsang Udo Junker Lothar J?ger Konrad Reinhart | 1999 | The Journal of Laboratory and Clinical Medicine1999，，1： | 1 |
| 11 | Measles virus transmission from dendritic cells to T cells:formation of synapse-like interfaces concentrating viral and cellular components显示文摘 | Susanne Koethe Elita Avota Sibylle | 2012 | Journal of virology2012，86，18： | 1 |
| 12 | Design and Development of a Multi-functional Laparoscopic Device显示文摘This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collects these three independent surgical tools in a single laparoscopic appendectomy device.These days there is a trend of moving to multi-functional surgery devices during minimally invasive surgery.The main reasons behind the minimal invasive surgery are to avoid changing the devices several times during the operation,to reduce the time spent in operation,to increase the efficiency of the operation,to facilitate the follow-up of the camera and devices,and to leave trocars to be used for other surgical instruments.The multi-functional appendectomy device that,we present here,provides these benefits.The standard trocar entries are appropriate for its usage.The presented multifunctional laparoscopic appendectomy device offers more practical use in comparison to individual devices.On the other hand,development of these multi-functional surgery devices can be directly enhanced to the robotic surgery devices. | Tugrul Tansug Elif Taskin Eray Kurt Meltem Elitas | 2019 | Journal of Mechanics Engineering and Automation2019，9，5： | 0 |
| 13 | 欧洲药品管理局批准的抗肿瘤药物总生存和生活质量获益证据的可用性:2009-2013年获批药物的回顾性队列研究显示文摘目的 确定欧洲批准的抗肿瘤药物总生存和生活质量获益数据的可用性。 设计 回顾性队列研究。 背景2009-2013年欧洲药品管理局(EMA)公开监管和科学报告的审批药物。 主要结局测量抗肿瘤药物上市后临床试验的设计特点(随机、交叉、盲法)、参考标准以及研究终点,在审批时和上市后确定的总生存获益或生活质量改善程度和可用性。经验证的欧洲临床肿瘤协会临床获益量表(ESMO-MCBS)用于评估发表的抗肿瘤药物研究报告的生存获益的临床价值。 | Courtney Davis Huseyin Naci Evrim Gurpinar Elita Poplavska Ashlyn Pinto Ajay Aggarwal 翟婧彤(译) 马飞(校) | 2018 | 英国医学杂志中文版2018，21，11： | 0 |
| 14 | 新潮小狗放暑假显示文摘你的小狗上过学吗? 那种认为狗是人类最好的朋友的说法, 或许更加适合西方的情况。西方人为狗提供了特殊的训练和护理中心、医院,甚至美容院,他们为狗而设的东西甚至超过了化妆品的范围。在那里,被精心装扮一番的小狗还拥有自己的选美比赛,并且可以赢得奖牌。 | Elita Karim Kim Tae-gyu 许婉燕 | 2006 | 疯狂英语(初中天地)2006，，7： | 0 |
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