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| 1 | Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells显示文摘Alzheimer’s disease (AD) is the most common form of dementia. To date, only five pharmacological agents have been approved by the Food and Drug Administration for clinical use in AD, all of which target the symptoms of the disease rather than the cause. Increasing our understanding of the underlying pathophysiology of AD will facilitate the development of new therapeutic strategies. Over the years, the major hypotheses of AD etiology have focused on deposition of amyloid beta and mitochondrial dysfunction. In this review we highlight the potential of experimental model systems based on human induced pluripotent stem cells (iPSCs) to provide novel insights into the cellular pathophysiology underlying neurodegeneration in AD. Whilst Down syndrome and familial AD iPSC models faithfully reproduce features of AD such as accumulation of Aβ and tau, oxidative stress and mitochondrial dysfunction, sporadic AD is much more difficult to model in this way due to its complex etiology. Nevertheless, iPSC-based modelling of AD has provided invaluable insights into the underlying pathophysiology of the disease, and has a huge potential for use as a platform for drug discovery. | Kate Elizabeth Hawkins Michael Duchen | 2019 | World Journal of Stem Cells2019，11，5： | 5 |
| 2 | “Sideways”: Results of Repair of Biliary Injuries Using a Policy of Side-To-Side Hepatico-Jejunostomy显示文摘 | Emily R. Winslow Elizabeth A. Fialkowski David C. Linehan William G. Hawkins Daniel D. Picus Steven M. Strasberg | 2009 | Annals of Surgery2009，，3： | 3 |
| 3 | Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas显示文摘 | Steven M. Strasberg Feng Gao Dominic Sanford David C. Linehan William G. Hawkins Ryan Fields Danielle H. Carpenter Elizabeth M. Brunt Carolyn Phillips | 2014 | HPB2014，，2： | 2 |
| 4 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 5 | Removing Splitting/Modeling Error in Projection/Penalty Methods for Navier-Stokes Simulations with Continuous Data Assimilation显示文摘We study continuous data assimilation(CDA)applied to projection and penalty methods for the Navier-Stokes(NS)equations.Penalty and projection methods are more efficient than consistent Ns discretizations,however are less accurate due to modeling error(penalty)and splitting error(projection).We show analytically and numerically that with measurement data and properly chosen parameters,CDA can effectively remove these splitting and modeling errors and provide long time optimally accurate solutions. | Elizabeth Hawkins Leo G.Rebholz Duygu Vargun | 2024 | Communications in Mathematical Research2024，40，1： | 0 |
| 6 | Overcoming tumor antigen heterogeneity in CAR-T cell therapy for malignant mesothelioma(MM)显示文摘Malignant mesothelioma(MM)is a rare,aggressive solid tumor with limited therapeutic options and poor therapeutic response.The role of immunotherapy in MM is now well established and therapeutic options,such as checkpoint inhibitors,are increasingly being approved.Chimeric antigen receptor(CAR)-T cell therapy is successfully implemented in several hematologic cancers,but currently has inadequate effect in solid tumors,owing to several limitations,such as trafficking and infiltration,limited T cell persistence and exhaustion,the immunosuppressive TME and tumor antigen heterogeneity.The lack of uniform and universal expression of tumor-associated antigens(TAAs)on tumor cells,as well as TAA heterogeneity following tumor editing post-therapy,are issues of significant importance to CAR-T cell and associated antigen-targeting therapies.Our review discusses the concept of tumor antigen heterogeneity in MM,the consequences for CAR-T cell therapies and the strategies to overcome it. | Reena R.D'Souza Paraskevi Dimou Reyisa Bughda Elizabeth Hawkins Clara Leboreiro Babe Astero Klampatsa | 2022 | Journal of Cancer Metastasis and Treatment2022，8，1： | 0 |
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