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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Overexpression of glutathione synthetase in Indian mustard enhances cadmium accumulated and tolerance显示文摘 | Zhu Y L Elizabeth A H P S Jouanin L | 1999 | Plant Physiology1999，119，： | 1 |
| 3 | The tuberous sclerosis complex显示文摘 | Peter B C Katherine L N Elizabeth P H | 2006 | N Engl J Med2006，355，： | 1 |
| 4 | New combustion synthesis route to TiB2- Al2O3 显示文摘 | Ross H P Elizabeth A R | 2001 | Materials Research Bulletin2001，36，： | 1 |
| 5 | Physicochemical properties of nitrate aerosols: lmpllcations for the atmosphere显示文摘 | ELIZABETH R GIBSON P K GBASSIAN V H | 2006 | J Phys Chem A2006，110，11： | 1 |
| 6 | Cadmium tolerance and accumulation in indian mustard is enhanced by overexpressing γ-glutamylcysteine synthetase显示文摘 | ZHU Y L ELIZABETH A H SMIT P | 1999 | Plant Physiology1999，121，： | 1 |
| 7 | Genome-wide analysis of mutations in mutant lineages selected following fast-neutron irradiation mutagenesis of Arabidopsis thaliana显示文摘 | Eric J B Xiangchao G Aziz M Carly B Caifu J Keara F Elizabeth A Anjar W Marko J Kit B Sharan K Jiannis R Richard M Nicholas P H | 2012 | Genome Research2012，22，： | 1 |
| 8 | Venous thromboem￣bolism prevention in gynecologic cancer surgery:A systematic review显示文摘 | Heather E E M Elizabeth A P Ellen M H | 2007 | Gynecologic Oncology2007，105，3： | 1 |
| 9 | Physiological functions of beneficial elements显示文摘 | Elizabeth A H P S Colin F Q Wiebke T Mario M Michela S | 2009 | Current Opinion in Plant Biology2009，12，3： | 1 |
| 10 | High-Sensitivity C-reactive protein and soluble CD40 ligand as indices of inflammation and plateletactivation in 880 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors, stroke risk stratification schema,and prognosis显示文摘 | GREGORY Y H JEETESH V P ELIZABETH H | 2007 | Stroke2007，38，： | 1 |
| 11 | Flap thickness accuracy显示文摘 | Kerry D Solomon Eric Donnenfeld Helga P Sandoval Oday Al Sarraf Terrance J Kasper Mike P Holzer Elizabeth H Slate David T Vroman Flap Thickness Study Group | 2004 | Journal of Cataract & Refractive Surgery2004，，5： | 1 |
| 12 | The Mycobacterium avium subsp, paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cells 显示文摘 | Bannantine J P Jason F J H Elizabeth M | 2003 | Microbiology2003，149，： | 1 |
| 13 | Determination of trace triazine and chloroacetamide herbicides in tilefed drainage ditch water using solid-phase microextraction coupled with GC- MS 显示文摘 | CLEONICE R ELIZABETH A P HUANG C H | 2008 | Environmental Pollution2008，152，1： | 1 |
| 14 | Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis显示文摘 | Tania P Elizabeth H | 2005 | The Plant Journal2005，42，56： | 1 |
| 15 | Germline Transmission and Tissue Specific Expression of Transgenes Delivered by Lentiviral Vectors显示文摘 | Lois C Elizabeth J H Shirley P | 2002 | Science2002，295，： | 1 |
| 16 | Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial显示文摘 | David Neal Franz Elena Belousova Steven Sparagana E Martina Bebin Michael Frost Rachel Kuperman Olaf Witt Michael H Kohrman J Robert Flamini Joyce Y Wu Paolo Curatolo Petrus J de Vries Vicky H Whittemore Elizabeth A Thiele James P Ford Gaurav Shah Helene | 2012 | The Lancet2012，，： | 1 |
| 17 | The flishery on Antarctic krill defining an ecosystem approach to management显示文摘 | ROGER P H ELIZABETH L L | 2000 | Re- views in Fisheries Science2000，8，3： | 1 |
| 18 | First accuracy evaluation of NIST-F2显示文摘 | Thomas P Heavner Elizabeth A Donley Filippo Levi Giovanni Costanzo Thomas E Parker Jon H Shirley Neil Ashby Stephan Barlow S R Jefferts | 2014 | Metrologia2014，，3： | 1 |
| 19 | Mediated herbicide inhibition in a pet biosensor显示文摘 | Monika P Elizabeth A H | 1995 | Anal Chem1995，67，3： | 1 |
| 20 | Mediated herbicide inhibition in a pet biosensor显示文摘 | MONIKA P ELIZABETH A H | 1995 | Anal Chem1995，，67： | 1 |
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