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| 1 | 中国大陆居民对中风的危险因素、征兆、应急处理及信息获取等相关认知的调查研究(英文)显示文摘目的:以中国大陆居民为受访对象,就中风的认知和预防进行问卷调查,以推进预防中风的健康教育活动。方法:选择大陆两个主要城市(武汉和成都)公园、商场及其他公共场所的居民为对象,进行一项有关中风知识标准化的横截面问卷调查,内容包括风险因素、征兆、应急救援和信息获取。结果:846人参与问卷调查,其中55%为男性,45%为女性,平均年龄45.7岁。收集数据表明,28%的受调查居民认为高血压是主要的危险因素,头晕(29%)和麻木(20.2%)是中风常见的征兆。所有数据都显示,当中风时人们采取急救措施是有必要的。家庭/朋友(21%)及媒体(电视占19.5%,报纸占17.7%)是中风信息传播的主要途径。结论:应重视推广中国大陆地区有关中风预防的低成本高效率的教育项目,尤其是中风危险因素、征兆、应急处理和信息获取途径的相关项目。开拓多元化的途径,包括开展促进公众健康的活动,通过医疗专家和医疗设施开展健康教育活动向广大民众宣传中风常识和预防措施。 | Zhenyi LI Peng WANG Alice Y M JONES Elizabeth DEAN | 2015 | 康复学报2015，0，2： | 3 |
| 2 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 3 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 4 | 通过模拟学习最大限度地提高物理治疗的临床实习成效(英文)显示文摘本文描述物理治疗专业和物理治疗入门级教育在中国康复医学教育中的演变,提倡以模拟学习技术(simulation-based learning,SBL)为临床实习生积累经验。与医学专业的学生一样,物理治疗专业学生的教育需要一个结构化的临床教育方案,以确保毕业时具备一定的临床专业能力。SBL多年以来一直是医学、工程以及航空专业的首选教学模式。在物理治疗专业培养方案中,SBL培养临床技能的教学模式已经出现。本文亦论述SBL在物理治疗专业入门级教育中的优势,尤其是使用模拟标准化患者作为核心临床教育内容,为学生进入临床实习做好准备。我们建议中国可以将SBL应用在物理治疗专业人才培养方案中,这能够最大限度地提高学生的临床实习经验。 | Alice Y M JONES Margot A SKINNER Elizabeth DEAN | 2015 | 康复学报2015，25，1： | 2 |
| 5 | Probiotics and prebiotics in dermatology显示文摘 | Katherine L Baquerizo N Elizabeth Y | 2014 | Journal of American Academy of Dermatology2014，71，4： | 1 |
| 6 | Adjacent segment disease : an uncommon complication after cervical expansile laminoplasty : case re- port显示文摘 | Michael Y Barth A Elizabeth V | 2003 | Neurosurgery2003，53，： | 1 |
| 7 | Discourse on the BCL-2 Family and Cell Death显示文摘 | Elizabeth Y Stanley J Korsmeyer A | 1996 | Blood1996，88，2： | 1 |
| 8 | Overexpression of glutathione synthetase in Indian mustard enhances cadmium accumulated and tolerance显示文摘 | Zhu Y L Elizabeth A H P S Jouanin L | 1999 | Plant Physiology1999，119，： | 1 |
| 9 | Cepharanthine is a potent reversal agent for MRP7 (ABCC10)-mediated multidrug resistance显示文摘 | Zhou Y Elizabeth H B Shen T | 2009 | Biochemical Pharmacology2009，77，6： | 1 |
| 10 | Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents显示文摘 | ZHOU Y ELIZABETH O HILEMAN | 2003 | Blood2003，101，： | 1 |
| 11 | Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study显示文摘 | Elizabeth Montgomery John R Goldblum Joel K Greenson Marian M Haber Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Kay Washington Marianna L Zahurak John Hart | 2001 | Human Pathology2001，，： | 1 |
| 12 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，： | 1 |
| 13 | Effecls of yogurt searter cutture on the survival of LactobaciUus acidophils显示文摘 | Elizabeth W Marie Y PhiUip S | 2010 | Intemaional toumal of Food Miembiology2010，75，1： | 1 |
| 14 | A Population-Based Analysis of Temporal Trends in the Incidence of Squamous Anal Canal Cancer in Relation to the HIV Epidemic显示文摘 | Elizabeth Y Chiao Susan E Krown Elizabeth A Stier Deborah Schrag | 2005 | JAIDS Journal of Acquired Immune Deficiency Syndromes2005，，4： | 1 |
| 15 | Cadmium tolerance and accumulation in Indian mustard is enhanced by overexpressing γ-glutamylcysteine synthetase 显示文摘 | Zhu Y L Elizabeth A H | 1999 | Plant Physiol1999，121，： | 1 |
| 16 | In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng 显示文摘 | Wang W Zhao Y Q Elizabeth R | 2006 | Cancer Chem Pharm2006，10，： | 1 |
| 17 | Selenium in higher plants : and phytoremediation 显示文摘 | ZHU Y G Elizabeth A H PILON - SMITS | 2009 | Trends in Plant Seienee2009，14，： | 1 |
| 18 | Low pressure plasma spray coating显示文摘 | Elizabeth J Y Eli M John J M | 2002 | Thin Solid Films2002，，： | 1 |
| 19 | Cadmium tolerance and accumulation in indian mustard is enhanced by overexpressing γ-glutamylcysteine synthetase显示文摘 | ZHU Y L ELIZABETH A H SMIT P | 1999 | Plant Physiology1999，121，： | 1 |
| 20 | Layered double hydroxides pillared by macropolyoxometalates显示文摘 | Elizabeth A G Sang K Y Taehyun K | 1998 | Applied Clay Science1998，13，： | 1 |
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