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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Head-to-head comparison of N-terminal pro-brain natriuretic peptide, brain natriuretic peptide and N-terminal pro-atrial natriuretic peptide in diagnosing left ventricular dysfunction显示文摘 | Angelika Hammerer-Lercher Elke Neubauer Silvana Müller Otmar Pachinger Bernd Puschendorf Johannes Mair | 2001 | Clinica Chimica Acta2001，，2： | 2 |
| 3 | Nutrient removal efficiency and resource economics of vertical flow and horizontal flow constructed wetlands显示文摘 | Volker Luederitz Elke Eckert Martina Lange-Weber Andreas Lange Richard M Gersberg | 2001 | Ecological Engineering2001，，2： | 2 |
| 4 | Close to recommended caloric and protein intake by enteral nutrition is associa- ted with better clinical outcome of critically ill septic pa- tients: secondary analysis of a large international nutri- tion database显示文摘 | Elke G Wang M Weiler N | 2014 | Crit Care2014，18，1： | 1 |
| 5 | A review of high-frequency radar cross section analysis capabilities at McDonnell Douglas aerospace显示文摘 | ELKING D M ROEDDER J M | 1995 | IEEE Antennas and Propagation Magazine1995，37，5： | 1 |
| 6 | Proposed mecha- nisms of cholsterol-lowering action of plant sterols 显示文摘 | Elke A T Guus S M J Duchateau E | 2003 | Euro- pean Journal of Lipid Science and Technology2003，105，： | 1 |
| 7 | First missense mutation in the SOST gene causing selerosteosis by loss of selerostin function 显示文摘 | Elke P Cavit C Martiene M | 2010 | Hum Mutat2010，31，： | 1 |
| 8 | Type 2 diabetes mellitus and gender-specific risk for colorectal neoplasia显示文摘 | Heike Kr?mer Heiko Müller Christa Stegmaier Dietrich Rothenbacher Elke Raum Hermann Brenner | 2012 | European Journal of Epidemiology2012，，5： | 1 |
| 9 | Biological sulfate removal from tannery wastewater in a two - stage anaerobic 显示文摘 | Elke G Werner H Christian M | 1996 | Water Research1996，30，9： | 1 |
| 10 | NF-kappaB- induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type lI diabetes 显示文摘 | Mariappan N Elks C M Sriramula S | 2010 | Cardiovasc Res2010，85，3： | 1 |
| 11 | Using taxonomies for content-based routing with ants 显示文摘 | ELKE M ARNO P GERTI K | 2007 | Journal of Computer Networks2007，51，16： | 1 |
| 12 | National Institute of Mental Health pilot study in training mental health counselors显示文摘 | Rioch M Elkes C Flint A | 1963 | Am J Orthophychiatry1963，33，： | 1 |
| 13 | Perceived risk attitudes: relating risk perception to risky choice显示文摘 | Elke U W Richard A M | 1997 | Management Science1997，43，2： | 1 |
| 14 | Enteral nutrition is associated with improved outcome in patients with severe sepsis 显示文摘 | Elke G Kuhnt E Ragaller M | 2013 | Med Klin IntensiVmed Notfmed2013，108，3： | 1 |
| 15 | The influence of lactic bacteria on the quality of malt显示文摘 | DEIRDRE P ELKE K ALMUDENA M | 2005 | J Inst Brew2005，111，： | 1 |
| 16 | Laccase-induced cross-coupling of 4-aminobenzoic acid with para-dihydroxylated compounds 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide and 2,5-dthydroxybenzoic acid methyl ester显示文摘 | Katrin M Elke H Annett M T | 2005 | Journal of Molecular Catalysis B: Enzymatic2005，，35： | 1 |
| 17 | Association between insulin secretion,insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies显示文摘 | Ruchat S M Elks C E Loos R J Vohl M C Weisnagel S J Rankinen T | 2009 | Acta Diabetol2009，46，： | 1 |
| 18 | Nanographitic impurities areresponsible for electrocatalytic activity of carbon nanotubestowards oxidation of carbamazepine 显示文摘 | CHNG ELK PUMERA M | 2011 | ElectrochemistryCommunications2011，13，8： | 1 |
| 19 | Improved outcome of pa-tients with severe sepsis and prolonged ICU stay receiving moderate energy intake by enteral nutrition compared to mixed nutrition显示文摘 | Elke G Kuhnt E Ragaller M | | 0，，02： | 1 |
| 20 | Traumatic memories of war veterans: Not so special after all显示文摘 | Elke G Dragica KK Harald M | 2007 | Conse Cognit2007，，35： | 1 |
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