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| 1 | Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis显示文摘 | Katrin M Sjoquist Bryan H Burmeister B Mark Smithers John R Zalcberg R John Simes Andrew Barbour Val Gebski | 2011 | Lancet Oncology2011，，7： | 4 |
| 2 | Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab显示文摘AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease.METHODS:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts:(1) the AGITG MAX trial(Phase Ⅲ randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine,bevacizumab and mitomycin C);(2) the prospective Treatment of Recurrent and Advanced Colorectal Cancer(TRACC) registry(any first-line regimen ± bevacizumab);and(3) two cancer centres in New South Wales,Australia [Macarthur Cancer Therapy Centre and Liverpool Cancer Therapy Centre(NSWCC) from January 2005 to Decenber 2012,(any first-line regimen ± bevacizumab).For the AGITG MAX trial capecitabine was compared to the other two arms(capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycin C).In the AGITG MAX trial and the TRACC registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal metastases.Secondary endpoints included progression-free survival,chemotherapy duration,and overall survival.Time-toevent outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test.RESULTS:Eighty-four MAX,179 TRACC and 69 NSWCC patients had peritoneal disease.There were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWCC cohorts.Of the patients without peritoneal disease in the MAX trial,4/300(1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123(0.8%) in the capecitabine alone arm.In the TRACC registry 3/126(2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53(1.9%) in the chemotherapy alone arm.In a further analysis of patients without peritoneal metastases in the TRACC registry,the rate of gastrointestinal perforations was 9/369(2.4%) in the chemotherapy/bevacizumab group and 5/177(2.8%) in the chemotherapy alone group.The addition of bevacizumab to chemotherapy was associated with improved progression-free survival in all three cohorts:MAX 6.9 m vs 4.9 m,HR = 0.64(95%CI:0.42-1.02);P = 0.063;TRACC 9.1 m vs 5.5 m,HR = 0.61(95%CI:0.37-0.86);P = 0.009;NSWCC 8.7 m vs 6.8 m,HR = 0.75(95%CI:0.43-1.32);P = 0.32.Chemotherapy duration was similar across the groups.CONCLUSION:Patients with peritoneal disease do not appear to have an increased risk of gastrointestinal perforations when receiving first-line therapy with bevacizumab compared to systemic therapy alone. | Aflah Roohullah Hui-Li Wong Katrin M Sjoquist Peter Gibbs Kathryn Field Ben Tran Jeremy Shapiro Joe Mckendrick Desmond Yip Louise Nott Val Gebski Weng Ng Wei Chua Timothy Price Niall Tebbutt Lorraine Chantrill | 2015 | World Journal of Gastroenterology2015，21，17： | 3 |
| 3 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 4 | Erratum to “Citations, family size, opposition and the value of patent rights” [Research Policy 32 (2003) 1343–1363]显示文摘 | Dietmar Harhoff Frederic M Scherer Katrin Vopel | 2003 | Research Policy2003，，2： | 1 |
| 5 | Clincial conse- quences of untreated dental caries in German 5 and 8-year-olds 显示文摘 | KATRIN GRUND INKA GODDON INA M et at | 2015 | BMC Oral Health2015，15，1： | 1 |
| 6 | Development of an ex vivo retention model simulating bioadhesion in the oral cavity using human saliva and physiologically relevant irrigation media显示文摘 | KATRINE D M CAMILLA S STEFANIA B | 2013 | International Journal of Pharmaceutics2013，448，2： | 1 |
| 7 | Larval food plants can regulate the cabbage moth, Mamestra brassicae population显示文摘 | Luule M Eha K Katrin J | 2013 | Bulletin of Insectology2013，66，1： | 1 |
| 8 | The Influence of Strategic Patenting on Companies' Patent Portfolios 显示文摘 | Knut B Katrin C Elisabeth M | 2009 | Research Policy2009，38，2： | 1 |
| 9 | Dead wood in European beech (Fagus sylvatica ) forest reserves 显示文摘 | Morten C Katrine H Edward P M | 2005 | Forest Ecology and Management2005，210，2： | 1 |
| 10 | Citations, family size, opposition and the value of patent rights 显示文摘 | DIETMAR HARHOFF FREDERIC M SCHERER KATRIN VOPEL | 2003 | Research Policy2003，，32： | 1 |
| 11 | Laccase-induced cross-coupling of 4-aminobenzoic acid with para-dihydroxylated compounds 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide and 2,5-dthydroxybenzoic acid methyl ester显示文摘 | Katrin M Elke H Annett M T | 2005 | Journal of Molecular Catalysis B: Enzymatic2005，，35： | 1 |
| 12 | Modulation of Cyp3a11 mRNA expression by α-tocopherol but not γ-tocotrienol in mice显示文摘 | Dirk Kluth Nico Landes Paul Pfluger Katrin Müller-Schmehl Kathrin Weiss Christiane Bumke-Vogt Michael Ristow Regina Brigelius-Flohé | 2004 | Free Radical Biology and Medicine2004，，： | 1 |
| 13 | Sewage sludge and liquid pig manure as possible sources of antibiotic resistant bacteria显示文摘 | Christina S. H?lzel Karin Schwaiger Katrin Harms Helmut Küchenhoff Anne Kunz Karsten Meyer Christa Müller Johann Bauer | 2010 | Environmental Research2010，，4： | 1 |
| 14 | Development and internal validation of the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score:is the patient suitable for Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)?显示文摘Background:Preoperative patient selection in Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)is not always reliable with currently available scores,particularly in patients with primary liver tumor.This study aims to(I)to determine whether comorbidities and patients characteristics are a risk factor in ALPPS and(II)to create a score predicting 90-day mortality preoperatively.Methods:Thirteen high-volume centers participated in this retrospective multicentric study.A risk analysis based on patient characteristics,underlying disease and procedure type was performed to identify risk factors and model the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score.A nonparametric receiver operating characteristic analysis was performed to estimate the predictive ability of our score against the Charlson Comorbidity Index(CCI),the age-adjusted CCI(aCCI),the ALPPS risk score before Stage 1(ALPPS-RS1)and Stage 2(ALPPS-RS2).The model was internally validated applying bootstrapping.Results:A total of 451 patients were included.Mortality was 14.4%.The CAPRA score is calculated based on the following formula:(0.1×age)−(2×BSA)+1(in the presence of primary liver tumor)+1(in the presence of severe cardiovascular disease)+2(in the presence of moderate or severe diabetes)+2(in the presence of renal disease)+2(if classic ALPPS is planned).The predictive ability was 0.837 for the CAPRA score,0.443 for CCI,0.519 for aCCI,0.693 for ALPPS-RS1 and 0.807 for ALPPS-RS2.After 1,000 cycles of bootstrapping the C statistic was 0.793.The accuracy plot revealed a cut-off for optimal prediction of postoperative mortality of 4.70.Conclusions:Comorbidities play an important role in ALPPS and should be carefully considered when planning the procedure.By assessing the patient’s preoperative condition in relation to ALPPS,the CAPRA score has a very good ability to predict postoperative mortality. | Ivan Capobianco Karl J.Oldhafer Mohammed-Hossein Fard-Aghaie Ricardo Robles-Campos Roberto Brusadin Henrik Petrowsky Michael Linecker Arianeb Mehrabi Katrin Hoffmann Jun Li Asmus Heumann Roberto Hernandez-Alejandro Mauro Enrique Tun-Abraham Elio Jovine Matteo Serenari Bergthor Bjornsson Per Sandström Ruslan Alikhanov Mikhail Efanov Paolo Muiesan Andrea Schlegel Thomas M.van Gulik Pim B.Olthof Gregor Alexander Stavrou Lina Maria Serna-Higuita Alfred Königsrainer Silvio Nadalin | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 1 |
| 15 | Construction of an S-layer protein exhibiting mtxiified serf-assembling properties and enhanced metal binding capacities 显示文摘 | KATRIN P SABINE M | 2007 | Appl Microbiol Biotechnol2007，75，： | 1 |
| 16 | Development of polymer-based catalysts and membrane reactor tests显示文摘 | Etlev F Karsten K Katrin M | 2003 | Catalysis Today2003，82，： | 1 |
| 17 | Wolfgang Wiegand sixyear follow-up of laser in situ keratomileusis for moderate and extreme myopia using a first-generation excimer laser and microkeratome显示文摘 | Walter S Katrin B Peter M | 2003 | Cataract Refract Surg2003，29，： | 1 |
| 18 | Citations, Family Size, Opposition and the Value of Patent Rights 显示文摘 | Harhoff D Scherer F M Katrin V | 2003 | Research Policy2003，32，8： | 1 |
| 19 | The effect of antiplatelet drugs clopidogrel and aspirin is less imme- diately after stent implantation 显示文摘 | Jolanta M Siller-Matula Katrin Haberl | 2009 | Thrombosis Research2009，123，6： | 1 |
| 20 | The telomerase-associated protein P43 is involved in anchoring telomerase in the nucleus显示文摘 | Matthias M Jan P Katrin P | 2003 | J Cell Sci2003，116，9： | 1 |
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