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| 1 | Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review显示文摘BACKGROUND After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography(ICGA) is an easy assessment tool for gastric tube(GT) perfusion, and it might predict anastomotic leakage(AL).AIM To evaluate feasibility and effectiveness of ICGA in GT perfusion assessment and as a predictor of AL.METHODS This study was designed according to the PRISMA guidelines and registered in the PROSPERO database. PubMed and EMBASE were independently searched by 2 reviewers for studies presenting data on intraoperative ICGA GT perfusion assessment during esophago-gastric reconstruction after esophagectomy.Relevant outcomes such as feasibility, complications, intraoperative surgical changes based on ICGA findings, quantification attempts, anatomical data and the impact of ICGA on postoperative anastomotic complications, were collected by 2 independent researchers. The quality of the included articles was assessed based on the Methodological Index for Non-Randomized Studies. The 19 included studies presented data on 1192 esophagectomy patients, in 758 patients ICGA was used perioperative to guide esophageal reconstruction.RESULTS The 19 included studies for qualitative analyses all described ICGA as a safe and easy method to evaluate gastric graft perfusion. AL occurred in 13.8% of the entire cohort, 10% in the ICG guided group and 20.6% in the control group(P <0.001). When poorly perfused cases are excluded from the analyses, the difference in AL was even larger(AL well-perfused group 6.3% vs control group 20.5%, P <0.001). The AL rate in the group with an altered surgical plan based on the ICG image was 6.5%, similar to the well perfused group(6.3%) and significantly less than the poorly perfused group(47.8%)(P < 0.001), suggesting that the technique is able to identify and alter a potential bad outcome.CONCLUSION ICGA is a safe, feasible and promising method for perfusion assessment. The lower AL rate in the well perfused group suggest that a good fluorescent signal predicts a good outcome. | Elke Van Daele Yves Van Nieuwenhove Wim Ceelen Christian Vanhove Bart P Braeckman Anne Hoorens Jurgen Van Limmen Oswald Varin Dirk Van de Putte Wouter Willaert Piet Pattyn | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 3 |
| 2 | Fast HPLC determination of serum free fatty acids in the picomole range显示文摘 | Micharel P Harald K Elke Von O | 1993 | Clin Chem1993，39，5： | 1 |
| 3 | Mortality in Pennsylvania 显示文摘 | Arthur L H Daniel captive elk ( Cervus 2007 19(3) : 334 P S Jenny S F elaphus) : 1998-2006 -337 | 2007 | J Vet Diagn Invest2007，，： | 1 |
| 4 | First missense mutation in the SOST gene causing selerosteosis by loss of selerostin function 显示文摘 | Elke P Cavit C Martiene M | 2010 | Hum Mutat2010，31，： | 1 |
| 5 | Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies显示文摘 | Elks CE Perry JR Sulem P | | 0，，12： | 1 |
| 6 | Thirty new loci for age at menarche identified by a meta - analysis of genome - wide associa- tion studies显示文摘 | Elks CE Perry JR Sulem P | 2010 | Nat Genet2010，42，12： | 1 |
| 7 | Using taxonomies for content-based routing with ants 显示文摘 | ELKE M ARNO P GERTI K | 2007 | Journal of Computer Networks2007，51，16： | 1 |
| 8 | Protective role of catalase in Pseudomonas aeruginosa biofilm resistance to hydrogen peroxide显示文摘 | Elking J G Hassett D J Stewart P S | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 9 | The influence of lactic bacteria on the quality of malt显示文摘 | DEIRDRE P ELKE K ALMUDENA M | 2005 | J Inst Brew2005，111，： | 1 |
| 10 | Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies 显示文摘 | Elks CE Perry JR Sulem P | 2010 | Nat Genet2010，42，12： | 1 |
| 11 | Water-soluble dietary fibers and cardiovascular disease显示文摘 | Elke Theuwissen Ronald P Mensink | 2008 | Physiology & Behavior2008，94，： | 1 |
| 12 | The removal of carbon dioxide with activated solutions of methyl-diethanolamine显示文摘 | van Loo S Elk E P Versteeg G F | 2007 | Journal of Petroleum Science and Engineering2007，55，12： | 1 |
| 13 | The use and effects of lactic acid bacteria in malting and brewing with their relationships to antifungal activity,mycotoxins and gushing:a review显示文摘 | Deirdre P Lowe Elke K Arendt | 2004 | The Institute & Guild of Brewing2004，110，3： | 1 |
| 14 | Contribution of amino acids to strawberry fruit quality and their relevance as stress indicators under NaCI salinity显示文摘 | Anna J K Elke P | 2008 | Food Chemistry2008，111，4： | 1 |
| 15 | Increased dietary intake of co-3 polyunsaturated fatty acidsreduces pathological retinal angiogenesis显示文摘 | Kip M C San Giovanni J P Lofqvist C Christopher M A Chen J HiguchiA Hong S Elke A P Majchrzak S Carper D Ann H Kang J X Emily Y C Norman S Charles N S | 2007 | Nature Medicine2007，13，： | 1 |
| 16 | Using taxonomies for content-based routing with ants 显示文摘 | Elke M Amo P Gerti K | 2007 | Computer Networks2007，51，16： | 1 |
| 17 | Fast HPLC determination of serum free fatty acids in the picomole range显示文摘 | Michael P Harald K Elke von O | 1993 | Clin Chem1993，39，5： | 1 |
| 18 | Acinetobacter strains IH9 and OCI1, two rhizospheric phosphate solubilizing isolates able to promote plant growth, constitute a new genomovar ofAcinetobacter calcoaceticus显示文摘 | Alvaro P Elke L Susanne V Cathrin S Rau'lR Ignacio SR Pedro FM Eustoquio MM Claudino RB Encama V | 2009 | Systematic and Applied Microbiology2009，32，5： | 1 |
| 19 | Single-step method of RNA isolation by acid gnanidinium thiocyauate-phenolchloroform extraction显示文摘 | Chomezyuski P Elke D | 1987 | Analytical Biochemistry1987，162，： | 1 |
| 20 | Review: water-soluble dietary fibers and cardiovascular disease 显示文摘 | Elke Theuwissen Ronald P Mensink | 2008 | Physiology & Behavior2008，94，： | 1 |
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