|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H pylori and host interactions that influence pathogenesis显示文摘H pylori is probably the most prevalent human patho- gen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I car- cinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduo- denal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory re- sponse that becomes chronic, along with a detectable adaptive immune response, these responses are ineffec- tive in clearing the infection. H pylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they inter- act with the host epithelium to influence pathogenesis. | Ellen J Beswick Giovanni Suarez Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，35： | 20 |
| 2 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 3 | CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract显示文摘CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract. | Ellen J Beswick Victor E Reyes | 2009 | World Journal of Gastroenterology2009，15，23： | 10 |
| 4 | Immune evasion strategies used by Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival. | Taslima T Lina Shatha Alzahrani Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 7 |
| 5 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 6 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 7 | Self - management program improves anticoaglation control and quality of life : A prospective randomized study 显示文摘 | Mohamed A Soliman H Ellen Van E | 2009 | Eur J Cardiothorac Surg2009，35，2： | 1 |
| 8 | Dental fear and anxiety levels of patients attending a dental clinic 显示文摘 | Ellen H Akarslan ZZ Bodrumlu E | 2006 | Quintessence Int2006，37，4： | 1 |
| 9 | Annum healthcare spending attributable to cigarette smoking: an update显示文摘 | XIN X U ELLEN E BISHOP S | 2015 | Am J Prey Med2015，48，3： | 1 |
| 10 | Peak discharge estimates of glacia-lake outburst floods and 'normal' climatic floods in the Mount Everest region,Nepal显示文摘 | DANIEL A C ELLEN E W | 2001 | Geomorphology2001，，1： | 1 |
| 11 | Fluorometric Assay of Alkaline Phosphatase in Dairy Products显示文摘 | de JONG E MAHULETTE G ELLEN G | 1993 | Voedings Middelen Technologies1993，23，： | 1 |
| 12 | Evaluation of a fully covered self-ex- pandable metal stent in liver transplant patients with bile leaks : mid-term analysis 显示文摘 | Phillips M S Saue B Bonatti H Rehan M E Smith L A Ellen K | 2009 | Gastrointest Endosc2009，69，： | 1 |
| 13 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 14 | Influences of Customer Differences of Loyalty, Perceived Risk and Category Experience on Customer Satisfaction Ratings 显示文摘 | Johnson M S Garbarino Ellen Sivadas E | 2006 | International Journal of Market Research2006，48，5： | 1 |
| 15 | Insulin desensitization withinsulin lispro and an insulin pump in 5 year old child显示文摘 | SAJU S E ELLEN L C JAMES E G | 2000 | Ann Al-lergy Asthma Immunol2000，85，5： | 1 |
| 16 | Dietary intakes of some essential and non-essential trace elements, nitrate nitrite and N-nitrosoamines by Duch adults estimated via a 24 hour duplicate portion study显示文摘 | Ellen G Egmond E Van Loon | 1990 | Food Addit Contam1990，7，2： | 1 |
| 17 | Materials and technologies for SOFC-components显示文摘 | Ellen Ivers-Tiffée André Weber Dirk Herbstritt | 2001 | Journal of the European Ceramic Society2001，，10： | 1 |
| 18 | Self - manage- ment program improves anticoaglation control and quality of life: A prospective randomized study显示文摘 | Mohamed A Soliman H Ellen Van E | 2009 | Eur J Cardiothorac Surg2009，35，2： | 1 |
| 19 | Poly(propylene imine) dendrimers:Large-scale synthesis by hetereogeneously catalyzed hydrogenations显示文摘 | Ellen M M de Brabander-van den Berg Meijer E W | 1993 | Angew Chem Int Ed Engl1993，32，9： | 1 |
| 20 | Dietary intakes of someessential and non- essential trace elements, nitrate, nitrite and Nnitrosamines,by Dutch adults: estimated via a 24- hour duplicateportion study显示文摘 | Ellen G Egmond E Van Loon J W | 1990 | Food Addit Contam1990，7，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员